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Inherited predisposition to breast and ovarian cancer in non-Jewish populations in Israel

  • Epidemiology
  • Published:
Breast Cancer Research and Treatment Aims and scope Submit manuscript

Abstract

Purpose

The contribution of genetic factors to cancer in non-Jewish populations in Israel is understudied. Yet the early, mostly premenopausal age at breast cancer diagnosis is suggestive of an inherited predisposition.

Methods

High-risk cancer cases of non-Jewish origin who were counseled at the Oncogenetics unit, Sheba Medical Center and the oncology institute at the Ziv medical center from January 1, 2000 to December 31 2016 were eligible. DNA extracted from leukocytes was subjected to massive parallel, next-generation sequencing using the Color Genomics platform. Data were analyzed for pathogenic and likely pathogenic mutations using existing pipelines.

Results

Overall, 68 cases, each representing a unique high-risk breast/ovarian family, were genotyped: 32 Druze, 26 Muslim Arabs, and 10 Christian Arabs. Fifty-nine had breast cancer (mean age at diagnosis 42.7 ± 7.6 years), and 9 had ovarian cancer (51.6 ± 9.7 years). Overall three pathogenic mutations one each in BRCA1, PALB2, and BRIP1 genes were detected mostly in Druze families. In addition, 29 variants of unknown significance were also detected, and in 36 cases no sequence variants were noted in any of the genotyped genes.

Conclusion

The contribution of the known cancer susceptibility genes to the burden of inherited breast/ovarian cancer predisposition in non-Jews in Israel is modest. Other genes or molecular mechanisms account for the familial breast/ovarian cancer clustering in this population.

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Acknowledgements

The study was in part sponsored by a grant from the Friends of Ziv Medical Center, a non-profit organization. We wish to thank Yotam Elimelech for technical assistance and all the families who participated in this study.

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Authors and Affiliations

  1. Oncology Institute, Ziv Medical Center and Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, Israel

    Jamal Zidan & Julia Schnaider

  2. Color Genomics, Burlingame, CA, USA

    Alicia Y. Zhou & Jeroen van den Akker

  3. Susanne Levy Gertner Oncogenetics Unit, The Danek Gertner Institute of Human Genetics, Chaim Sheba Medical Center, 52621, Tel-Hashomer, Israel

    Yael Laitman, Hagit Schayek & Eitan Friedman

  4. Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel

    Eitan Friedman

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  1. Jamal Zidan
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Correspondence to Eitan Friedman.

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Conflict of interest

Alicia Y. Zhou and Jeroen van den Akker are employed by Color Genomics and are Color Genomics stockowners. All other authors declare no conflicts of interest.

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Zidan, J., Zhou, A.Y., van den Akker, J. et al. Inherited predisposition to breast and ovarian cancer in non-Jewish populations in Israel. Breast Cancer Res Treat 166, 881–885 (2017). https://doi.org/10.1007/s10549-017-4474-3

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  • DOI: https://doi.org/10.1007/s10549-017-4474-3

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