This is a preview of subscription content, log in via an institution to check access.
References
Tauchi H, Matsuura S, Kobayashi J, Sakamoto S, Komatsu K (2002) Nijmegen breakage syndrome gene, NBS1, and molecular links to factors for genome stability. Oncogene 21:8967–8980
Assenmacher N, Hopfner KP (2004) MRE11/RAD50/NBS1: complex activities. Chromosoma 113:157–166
Roznowski K, Januszkiewicz-Lewandowska D, Mosor M, Pernak M, Litwiniuk M, Nowak J (2008) I171V germline mutation in the NBS1 gene significantly increases risk of breast cancer. Breast Cancer Res Treat 110:343–348
Ziółkowska I, Mosor M, Wierzbicka M, Rydzanicz M, Pernak-Schwarz M, Nowak J (2007) Increased risk of larynx cancer in heterozygous carriers of the I171V mutation of the NBS1 gene. Cancer Sci 98:1701–1705
Nowak J, Mosor M, Ziółkowska I et al (2008) Heterozygous carriers of the I171V mutation of the NBS1 gene have a significantly increased risk of solid malignant tumors. Eur J Cancer 44:627–630
Mosor M, Ziółkowska I, Pernak-Schwarz M, Januszkiewicz-Lewandowska D, Nowak J (2006) Association of the heterozygous germline I171V mutation of the NBS1 gene with childhood acute lymphoblastic leukemia. Leukemia 20:1454–1456
Steffen J, Varon R, Mosor M, Maneva G, Maurer M, Stumm M, Nowakowska D, Rubach M, Kosakowska E, Ruka W, Nowecki Z, Rutkowski P, Demkow T, Sadowska M, Bidziński M, Gawrychowski K, Sperling K (2004) Increased cancer risk of heterozygotes with NBS1 germline mutations in Poland. Int J Cancer 111(1):67–71
Steffen J, Nowakowska D, Niwińska A, Czapczak D, Kluska A, Piatkowska M, Wiśniewska A, Paszko Z (2006) Germline mutations 657del5 of the NBS1 gene contribute significantly to the incidence of breast cancer in Central Poland. Int J Cancer 119:472–475
Cybulski C, Gorski B, Debniak T, Gliniewicz B, Mierzejewski M, Masojć B, Jakubowska A, Matyjasik J, Złowocka E, Sikorski A, Narod SA, Lubiński J (2004) NBS1 is a prostate cancer susceptibility gene. Cancer Res 64:1215–1219
Heikkinen K, Karppinen SM, Soini Y, Makinen M, Winqvist R (2003) Mutation screening of Mre11 complex genes: indication of RAD50 involvement in breast and ovarian cancer susceptibility. J Med Genet 40(12):e131
Heikkinen K, Rapakko K, Karppinen SM, Erkko H, Knuutila S, Lundan T, Mannermaa A, Borresen-Dale AL, Borg A, Barkardottir RB, Petrini J, Winqvist R (2006) RAD50 and NBS1 are breast cancer susceptibility genes associated with genomic instability. Carcinogenesis 27:1593–1599
Tommiska J, Seal S, Renwick A, Barfoot R, Baskcomb L, Jayatilake H, Bartkova J, Tallila J, Kaare M, Tamminen A, Heikkila P, Evans DG, Eccles D, Aittomaki K, Blomqvist C, Bartek J, Stratton MR, Nevanlinna H, Rahman N (2006) Evaluation of RAD50 in familial breast cancer predisposition. Int J Cancer 118:2911–2916
Uhrhammer N, Delort L, Bignon YJ (2009) Rad50 c.687delT does not contribute significantly to familial breast cancer in a French population. Cancer Epidemiol Biomarkers Prev 18:684–685
Cao AY, Hu Z, Yin WJ, Jin W, Shao ZM (2010) Some common mutations of RAD50 and NBS1 in western populations do not contribute significantly to Chinese non-BRCA1/2 hereditary breast cancer. Breast Cancer Res Treat 121:247–249
Acknowledgments
Maria Mosor is stipendee of the Foundation for Polish Science. The work was done at the Institute of Human Genetics, Polish Academy of Sciences, Poznań, Poland. This research was supported in part by the Grant from the Ministry of Sciences and Higher Education (NN407201737). We are grateful to Professor Anna Grzymala-Busse from the University of Michigan for the revision of the manuscript.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Mosor, M., Ziółkowska-Suchanek, I., Rożnowski, K. et al. RAD50 gene mutations are not likely a risk factor for breast cancer in Poland. Breast Cancer Res Treat 123, 607–609 (2010). https://doi.org/10.1007/s10549-010-0992-y
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10549-010-0992-y