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The role of suboptimal mitochondrial function in vulnerability to post-traumatic stress disorder

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Journal of Inherited Metabolic Disease

Abstract

Post-traumatic stress disorder remains the most significant psychiatric condition associated with exposure to a traumatic event, though rates of traumatic event exposure far outstrip incidence of PTSD. Mitochondrial dysfunction and suboptimal mitochondrial function have been increasingly implicated in several psychopathologies, and recent genetic studies have similarly suggested a pathogenic role of mitochondria in PTSD. Mitochondria play a central role in several physiologic processes underlying PTSD symptomatology, including abnormal fear learning, brain network activation, synaptic plasticity, steroidogenesis, and inflammation. Here we outline several potential mechanisms by which inherited (genetic) or acquired (environmental) mitochondrial dysfunction or suboptimal mitochondrial function, may contribute to PTSD symptomatology and increase susceptibility to PTSD. The proposed pathogenic role of mitochondria in the pathophysiology of PTSD has important implications for prevention and therapy, as antidepressants commonly prescribed for patients with PTSD have been shown to inhibit mitochondrial function, while alternative therapies shown to improve mitochondrial function may prove more efficacious.

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Authors and Affiliations

  1. Hayward Genetics Center, Tulane University School of Medicine, 1430 Tulane Ave, New Orleans, LA, 70112, USA

    Graeme Preston, Faisal Kirdar & Tamas Kozicz

  2. Department of Clinical Genomics, Mayo Clinic, Rochester, MN, USA

    Tamas Kozicz

  3. Department of Anatomy, Radboud University Medical Center, Nijmegen, Netherlands

    Tamas Kozicz

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  1. Graeme Preston
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  2. Faisal Kirdar
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Preston, G., Kirdar, F. & Kozicz, T. The role of suboptimal mitochondrial function in vulnerability to post-traumatic stress disorder. J Inherit Metab Dis 41, 585–596 (2018). https://doi.org/10.1007/s10545-018-0168-1

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