Skip to main content
SpringerLink
Log in

DNA Methyltransferases and Structural-Functional Specificity of Eukaryotic DNA Modification

  • Review
  • Published:
Biochemistry (Moscow) Aims and scope Submit manuscript

Abstract

Properties of the main families of mammalian, plant, and fungal DNA methyltransferases are considered. Structural-functional specificity of eukaryotic genome sequences methylated by DNA methyltransferases is characterized. The total methylation of cytosine in DNA sequences is described, as well as its relation with RNA interference. Mechanisms of regulation of expression and modulation of DNA methyltransferase activity in the eukaryotic cell are discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Abbreviations

DNA methylase:

DNA methyltransferase

Dnmt1, Dnmt2, Dnmt3:

DNA methylases of different mammalian families

TRD:

the site recognizing domain of DNA methylase

Masc:

DNA methylases of different families of the fungus Ascobolus

MET, CMT, DRM:

DNA methylases of different plant families

MIP:

methylation induced premeiotically

m5C:

5-methylcytosine

N:

any nucleoside

PTGS:

post-transcriptional gene silencing

TGS:

transcriptional gene silencing

RIP:

repeat induced point mutation

REFERENCES

  1. Vanyushin, B. F., and Belozersky, A. N. (1959) Dokl. Akad. Nauk SSSR, 129, 944–946.

    Google Scholar 

  2. Marinova, E. I., Vkadychenskaya, N. S., and Antonov, A. S. (1969) Dokl. Akad. Nauk SSSR, 185, 945–948.

    Google Scholar 

  3. Vanyushin, B. F., Tkacheva, S. G., and Belozersky, A. N. (1970) Nature, 225, 948–949.

    Article  PubMed  Google Scholar 

  4. Vanyushin, B. F., Mazin, A. L., Vasilyev, V. K., and Belozersky, A. N. (1973) Biochim. Biophys. Acta, 299, 397–403.

    PubMed  Google Scholar 

  5. Sulimova, G. E., Mazin, A. L., Vanyushin, B. F., and Belozersky, A. N. (1970) Dokl. Akad. Nauk SSSR, 193, 1422–1425.

    Google Scholar 

  6. Berdyshev, T. D., Korotaev, T. K., Boyarskikh, G. V., and Vanyushin, B. F. (1967) Biokhimiya, 32, 988–993.

    Google Scholar 

  7. Drozhdenyuk, A. P., Sulimova, G. E., and Vanyushin, B. F. (1976) Mol. Biol. (Moscow), 10, 1378–1386.

    Google Scholar 

  8. Vanyushin, B. F., Nemirovsky, I. E., Klemenko, V. V., Vasilyev, V. K., and Belozersky, A. N. (1973) Gerontologia, 19, 138–152.

    PubMed  Google Scholar 

  9. Burtseva, N. N., Azizov, Yu. M., Itkin, V. Z., and Vanyushin, B. F. (1977) Biokhimiya, 42, 1690–1696.

    Google Scholar 

  10. Vanyushin, B. F., and Romanenko, E. B. (1979) Biokhimiya, 44, 78–85.

    Google Scholar 

  11. Romanov, G. A., and Vanyushin, B. F. (1981) Biochim. Biophys. Acta, 653, 204–218.

    PubMed  Google Scholar 

  12. Sinsheimer, R. L. (1954) J. Biol. Chem., 208, 445–459.

    PubMed  Google Scholar 

  13. Sinsheimer, R. L. (1955) J. Biol. Chem., 215, 579–583.

    PubMed  Google Scholar 

  14. Shapiro, H. S., and Chargaff, E. (1960) Biochim. Biophys. Acta, 39, 68–82.

    Article  PubMed  Google Scholar 

  15. Doskocil, J., and Sorm, F. (1962) Biochim. Biophys. Acta, 55, 953–959.

    Article  PubMed  Google Scholar 

  16. Grippo, P., Iaccarino, M., Parisi, E., and Scarano, E. (1968) J. Mol. Biol., 36, 195–208.

    Article  PubMed  Google Scholar 

  17. Kirnos, M. D., Aleksandrushkina, N. I., and Vanyushin, B. F. (1981) Biokhimiya, 46, 1458–1474.

    Google Scholar 

  18. Gruenbaum, Y., Naveh Many, T., Cedar, H., and Razin, A. (1981) Nature, 292, 860–862.

    Article  PubMed  Google Scholar 

  19. Bird, A. P. (1986) Nature, 321, 209–213.

    Article  PubMed  Google Scholar 

  20. Gardiner-Garden, M., and Frommer, M. (1987) J. Mol. Biol., 196, 261–282.

    Article  PubMed  Google Scholar 

  21. Antequera, F., and Bird, A. (1993) Proc. Natl. Acad. Sci. USA, 90, 11995–11999.

    PubMed  Google Scholar 

  22. Antequera, F., and Bird, A. (1988) EMBO J., 7, 2295–2299.

    Google Scholar 

  23. Clark, S. J., Harrison, J., and Frommer, M. (1995) Nature Genet., 10, 20–28.

    Article  PubMed  Google Scholar 

  24. Selker, E. U., and Stevens, J. N. (1985) Proc. Natl. Acad. Sci. USA, 82, 8114–8118.

    PubMed  Google Scholar 

  25. Toth, M., Muller, U., and Doerfler, W. (1990) J. Mol. Biol., 214, 673–683.

    Article  PubMed  Google Scholar 

  26. Meyer, P., Niedenhof, I., and ten Lohuis, M. (1994) EMBO J., 13, 2084–2088.

    PubMed  Google Scholar 

  27. Bestor, T. H. (1990) Philos. Trans. R. Soc. Lond. B. Biol. Sci., 326, 179–187.

    PubMed  Google Scholar 

  28. Sapienza, C., Peterson, A., Rossant, J., and Balling, R. (1987) Nature, 328, 251–254.

    Article  PubMed  Google Scholar 

  29. Yoder, J. A., Walsh, C. P., and Bestor, T. H. (1997) Trends Genet., 13, 335–340.

    Article  PubMed  Google Scholar 

  30. Bestor, T. H. (1998) Nature, 393, 311–312.

    Article  PubMed  Google Scholar 

  31. Lauster, R., Trautner, T. A., and Nouer-Weidner, M. (1989) J. Mol. Biol., 206, 305–312.

    Article  PubMed  Google Scholar 

  32. Kumar, S., Cheng, X., Klimasauskas, S., Sha, M., Posfai, J., Roberts, R. J., and Wilson, G. G. (1994) Nucleic Acids Res., 22, 1–10.

    PubMed  Google Scholar 

  33. Klimasauskas, S., Kumar, S., Roberts, R. J., and Cheng, X. (1994) Cell, 76, 357–369.

    Article  PubMed  Google Scholar 

  34. Bestor, T., Laudano, A., Mattaliano, R., and Ingram, V. (1988) J. Mol. Biol., 203, 971–983.

    Article  PubMed  Google Scholar 

  35. Czank, A., Hauselmann, R., Page, A. W., Leonhardt, H., Bestor, T. H., Schaffner, W., and Hergersberg, M. (1991) Gene, 109, 259–263.

    Article  PubMed  Google Scholar 

  36. Tollefsbol, T. O., and Hutchinson, C. A., III (1995) J. Biol. Chem., 270, 18543–18550.

    Article  PubMed  Google Scholar 

  37. Yen, R. W., Vertino, P. M., Nelkin, B. D., Yu, J. J., el-Deiry, W., Cumaraswamy, A., Lennon, G. G., Trask, B. J., Celano, P., and Baylin, S. B. (1992) Nucleic Acids Res., 20, 2287–2291.

    PubMed  Google Scholar 

  38. Bestor, T. H. (1992) EMBO J., 11, 2611–2617.

    PubMed  Google Scholar 

  39. Margot, J. B., Aguirre-Arteta, A. M., Di Giacco, B. V., Pradhan, S., Roberts, R. J., Cardoso, M. C., and Leonhardt, H. (2000) J. Mol. Biol., 297, 293–300.

    Article  PubMed  Google Scholar 

  40. Zimermann, C., Guhl, E., and Graessmann, A. (1997) Biol. Chem., 378, 393–405.

    PubMed  Google Scholar 

  41. Leonhardt, H., Page, A. W., Weier, H. U., and Bestor, T. H. (1992) Cell, 71, 865–873.

    Article  PubMed  Google Scholar 

  42. Cumaraswamy, G., Lennon, G., Trask, B. J., Celano, B. J., and Baylin, S. B. (1992) Nucleic Acids Res., 20, 2287–2291.

    PubMed  Google Scholar 

  43. Chuang, L. S., Ian, H. I., Koh, T. W., Ng, H. H., Xu, G., and Li, B. F. (1997) Science, 277, 1996–2000.

    Article  PubMed  Google Scholar 

  44. Fuks, F., Burgers, W. A., Brehm, A., Hughes-Davies, L., and Kouzaridis, T. (2000) Nature Genet., 24, 88–91.

    Article  PubMed  Google Scholar 

  45. Smith, S. S., Kan, J. L. C., Baker, D. J., Kaplan, B. E., and Dembek, P. (1991) J. Mol. Biol., 217, 39–51.

    Article  PubMed  Google Scholar 

  46. Smith, S. S., Kaplan, B. E., Sowers, L. C., and Newman, E. M. (1992) Proc. Natl. Acad. Sci. USA, 89, 4744–4748.

    PubMed  Google Scholar 

  47. Christman, J. K., Sheikhnejad, G., Marasco, C. J., and Sufrin, J. R. (1995) Proc. Natl. Acad. Sci. USA, 92, 7347–7351.

    PubMed  Google Scholar 

  48. Buryanov, Ya. I., Zinoviev, V. V., Vienozhinskis, M. T., Malygin, E. G., Nesterenko, V. F., Popov, S. G., and Gorbunov, Yu. A. (1984) FEBS Lett., 168, 166–168.

    Article  PubMed  Google Scholar 

  49. Buryanov, Ya. I., Zinoviev, V. V., Gorbunov, Yu. A., Tuzikov, F. V., Rechkunova, N. I., Malygin, E. G., and Bayev, A. A. (1988) Gene, 74, 67–69.

    Article  PubMed  Google Scholar 

  50. Tollefsbol, T. O., and Hutchinson, C. A., III (1997) J. Mol. Biol., 269, 494–504.

    Article  PubMed  Google Scholar 

  51. Smith, S. S. (1994) Progr. Nucleic Acid. Res. Mol. Biol., 49, 65–111.

    Google Scholar 

  52. Bolden, A. H., Nalin, C. M., Ward, C. A., Poonian, M. S., and Weissbach, A. (1985) Mol. Cell. Biol., 6, 1135–1140.

    Google Scholar 

  53. Bolden, A., Ward, C., Nalin, C., and Weissbach, A. (1986) Progr. Nucleic Acids Res. Mol. Biol., 33, 231–250.

    Google Scholar 

  54. Li, E., Bestor, T. H., and Jaenisch, R. (1992) Cell, 69, 915–926.

    Article  PubMed  Google Scholar 

  55. Li, E., Beard, C., Forster, A. C., Bestor, T. H., and Jaenisch, R. (1993) Cold Spring Harbor Symp. Quant. Biol., 58, 297–305.

    PubMed  Google Scholar 

  56. Lei, H., Oh, S. P., Okano, M., Juttermann, R., Goss, K. A., Jaenisch, R., and Li, E. (1996) Development, 122, 3195–3205.

    PubMed  Google Scholar 

  57. Yoder, J. A., and Bestor, T. H. (1998) Hum. Mol. Genet., 7, 279–284.

    Article  PubMed  Google Scholar 

  58. Okano, M., Xie, S., and Li, E. (1998) Nucleic Acids Res., 26, 2536–2540.

    Article  PubMed  Google Scholar 

  59. Herman, A., Schmitt, S., and Jeltsch, A. (2003) J. Biol. Chem., 278, 31717–31721.

    Article  PubMed  Google Scholar 

  60. Lyko, F., Ramsahoye, B. H., and Jaenisch, R. (2000) Nature, 408, 538–540.

    Article  PubMed  Google Scholar 

  61. Okano, M., Xie, S., and Li, E. (1998) Nature Genet., 19, 219–220.

    Article  PubMed  Google Scholar 

  62. Finnegan, E. J., Genger, R. K., Peacock, W. J., and Dennis, E. S. (1998) Annu. Rev. Plant Physiol. Plant Mol. Biol., 49, 223–247.

    Article  PubMed  Google Scholar 

  63. Wilkinson, C. R., Bartlett, R., Nurse, P., and Bird, A. P. (1995) Nucleic Acids Res., 23, 203–210.

    PubMed  Google Scholar 

  64. Xie, S., Wang, Z., Okano, M., Nogami, M., Li, Y., He, W. W., Okumura, K., and Li, E. (1999) Gene, 236, 87–95.

    Article  PubMed  Google Scholar 

  65. Chen, T., Ueda, Y., Dodge, J., Wang, Z., and Li, E. (2003) Mol. Cell. Biol., 23, 5594–5605.

    Article  PubMed  Google Scholar 

  66. Okano, M., Bell, D. W., Haber, D. A., and Li, E. (1999) Cell, 99, 247–257.

    Article  PubMed  Google Scholar 

  67. Xu, G.-L., Bestor, T. H., Bourc’his, D., Hsieh, C. L., Tommerup, N., Bugge, M., Hulten, M., Qu, X., Russo, J. J., and Viegas-Pequignot, E. (1999) Nature, 402, 187–191.

    Article  PubMed  Google Scholar 

  68. Jeanpierre, M., Turleau, C., Aurias, A., Prieur, M., Ledeist, F., Fischer, A., and Viegas-Pequignot, E. (1993) Hum. Mol. Genet., 2, 731–735.

    PubMed  Google Scholar 

  69. Bourc’his, D., Xu, G. L., Lin, C. S., Bollman, B., and Bestor, T. H. (2001) Science, 294, 2536–2539.

    Article  PubMed  Google Scholar 

  70. Hata, K., Okano, M., Lei, H., and Li, E. (2002) Development, 129, 1983–1993.

    PubMed  Google Scholar 

  71. Chedin, F., Lieber, M. R., and Hsieh, C. L. (2002) Proc. Natl. Acad. Sci. USA, 99, 16916–16921.

    Article  PubMed  Google Scholar 

  72. Suetake, I., Shinozaki, F., Miyagawa, J., Takeshima, H., and Tajima, S. (2004) J. Biol. Chem., 279, 27816–27823.

    Article  PubMed  Google Scholar 

  73. Aapola, U., Liv, I., and Peterson, P. (2002) Nucleic Acids Res., 30, 3602–3608.

    Article  PubMed  Google Scholar 

  74. Ramsahoye, B. H., Biniskiewicz, D., Lyko, F., Clark, V., Bird, A. P., and Jaenish, R. (2000) Proc. Natl. Acad. Sci. USA, 97, 5237–5242.

    Article  PubMed  Google Scholar 

  75. Bachman, K. E., Rountree, M. R., and Baylin, S. B. (2001) J. Biol. Chem., 276, 32282–32287.

    Article  PubMed  Google Scholar 

  76. Finnegan, E. J., and Dennis, E. S. (1993) Nucleic Acids Res., 21, 2383–2388.

    PubMed  Google Scholar 

  77. Bernacchia, G., Primo, A., Giorgetti, L., Pitto, L., and Cella, R. (1998) Plant J., 13, 317–329.

    Article  PubMed  Google Scholar 

  78. Teerawanichpan, P., Chandrasekharan, M. B., Jiang, Y., Narangajavana, J., and Hall, T. C. (2004) Planta, 218, 337–349.

    Article  PubMed  Google Scholar 

  79. Finnegan, E. J., Peacock, W. J., and Dennis, E. S. (1996) Proc. Natl. Acad. Sci. USA, 93, 8449–8454.

    Article  PubMed  Google Scholar 

  80. Nakano, Y., Steward, N., Sekine, M., Kusano, T., and Sano, H. (2000) Plant Cell Physiol., 41, 448–457.

    Article  PubMed  Google Scholar 

  81. Pradhan, S., Cummings, M., Roberts, R. J., and Adams, R. L. P. (1998) Nucleic Acids Res., 26, 1214–1222.

    Article  PubMed  Google Scholar 

  82. Pradhan, S., and Adams, R. L. P. (1995) Plant J., 7, 471–481.

    Article  PubMed  Google Scholar 

  83. Theiss, G., Schleicher, R., Schimpff Weil, R., and Follmann, H. (1987) Eur. J. Biochem., 167, 89–96.

    Article  PubMed  Google Scholar 

  84. Vlasova, T. I., Demidenko, Z. N., Kirnos, M. D., and Vanyushin, B. F. (1995) Gene, 157, 279–281.

    Article  PubMed  Google Scholar 

  85. Giordano, M., Mattachini, M. E., Cella, R., and Pedrali-Noy, G. (1991) Biochem. Biophys. Res. Commun., 177, 711–719.

    Article  PubMed  Google Scholar 

  86. Henikoff, S., and Comai, L. (1998) Genetics, 149, 307–318.

    PubMed  Google Scholar 

  87. Lindroth, A. M., Cao, X., Jackson, J. P., Zilberman, D., McCallum, C. M., Henikoff, S., and Jacobsen, S. E. (2001) Science, 292, 2077–2080.

    Article  PubMed  Google Scholar 

  88. Papa, C. M., Springer, N. M., Muszynski, M. G., Meeley, R., and Kaeppler, S. M. (2001) Plant Cell, 13, 1919–1928.

    Article  PubMed  Google Scholar 

  89. Cao, X., Springer, N. M., Muszynski, M. G., Phillips, R. L., Kaeppler, S. M., and Jacobsen, S. E. (2000) Proc. Natl. Acad. Sci. USA, 97, 4979–4984.

    Article  PubMed  Google Scholar 

  90. Buryanov, Ya. I., Zakharchenko, N. S., Shevchuk, T. V., and Bogdarina, I. G. (1995) Gene, 157, 283–287.

    Article  PubMed  Google Scholar 

  91. Kakutani, T., Jeddeloh, J. A., Flowers, S. K., Munakata, K., and Richards, E. J. (1996) Proc. Natl. Acad. Sci. USA, 93, 12406–12411.

    Article  PubMed  Google Scholar 

  92. Shevchuk, T. V., Zakharchenko, N. S., D’yachenko, O. V., and Buryanov, Ya. I. (2001) Fiziol. Rast., 48, 556–561.

    Google Scholar 

  93. Vaucheret, H., Beclin, C., Elmayan, T., Fenerbach, F., Godon, C., Morel, J. B., Mourrain, P., Palauqui, J. C., and Vernettes, S. (1998) Plant J., 16, 651–659.

    Article  PubMed  Google Scholar 

  94. Matzke, M. A., Matzke, A. J. M., Primig, M., and Trnousky, J. (1989) EMBO J., 8, 643–649.

    Google Scholar 

  95. Napoli, C., Lemieux, C., and Jorgensen, R. (1990) Plant Cell, 2, 279–289.

    Article  PubMed  Google Scholar 

  96. Van der Krol, A. R., Mur, L. A., Beld, M., Mol, J. N. M., and Stuitje, A. R. (1990) Plant Cell, 2, 291–299.

    Article  PubMed  Google Scholar 

  97. Ratcliff, F., Harrison, B. D., and Baulcombe, D. C. (1997) Science, 276, 1558–1560.

    Article  Google Scholar 

  98. Meyer, P., Heidmann, I., and Niedenhof, I. (1993) Plant J., 4, 89–100.

    Article  PubMed  Google Scholar 

  99. Wassenegger, M., Heimes, S., Riedel, L., and Sanger, H. L. (1994) Cell, 76, 567–576.

    Article  PubMed  Google Scholar 

  100. Pelissier, T., Thalmeir, S., Kempe, D., Sanger, H. L., and Wassenegger, M. (1999) Nucleic Acids Res., 27, 1625–1634.

    Article  PubMed  Google Scholar 

  101. De Carvalho, F., Gheysen, G., Kushnir, S., van Montagu, M., Inze, D., and Castresana, C. (1992) EMBO J., 11, 2595–2602.

    PubMed  Google Scholar 

  102. Ingelbrecht, I., van Houdt, H., van Montagu, M., and Depicker, A. (1994) Proc. Natl. Acad. Sci. USA, 91, 10502–10506.

    PubMed  Google Scholar 

  103. Mette, M., van der Winden, J., Matzke, M. A., and Matzke, A. J. M. (1999) EMBO J., 18, 241–248.

    Article  PubMed  Google Scholar 

  104. Waterhause, P. M., Graham, M. W., and Wang, M.-B. (1998) Proc. Natl. Acad. Sci. USA, 95, 13959–13964.

    Article  PubMed  Google Scholar 

  105. Fire, A. (1999) Trends Genet., 15, 358–363.

    Article  PubMed  Google Scholar 

  106. Hamilton, A. J., and Baulcombe, D. C. (1999) Science, 286, 950–952.

    Article  PubMed  Google Scholar 

  107. Zamore, P., Tuschl, T., Sharp, P., and Bartel, D. (2000) Cell, 101, 25–33.

    Article  PubMed  Google Scholar 

  108. Zilberman, D., Cao, X., and Jacobsen, S. (2000) Science, 299, 716–719.

    Article  Google Scholar 

  109. Aufsatz, W., Mette, M. F., van der Winden, J., Matzke, A. J. M., and Matzke, M. (2002) Proc. Natl. Acad. Sci. USA, 99, 16499–16506.

    Article  PubMed  Google Scholar 

  110. Jacobsen, S. E., and Meyerowitz, E. M. (1997) Science, 277, 1100–1103.

    Article  PubMed  Google Scholar 

  111. Jacobsen, S. E., Sakai, H., Finnegan, E. J., Cao, X., and Meyerowitz, E. M. (2000) Curr. Biol., 10, 179–186.

    Article  PubMed  Google Scholar 

  112. Baylin, S. B., Herman, J. G., Graff, J. R., Vertino, P. M., and Issa, J.-P. (1998) Adv. Cancer Res., 72, 141–196.

    PubMed  Google Scholar 

  113. Schmitt, F., Oakeley, E. J., and Jost, J. P. (1997) J. Biol. Chem., 272, 1534–1540.

    Article  PubMed  Google Scholar 

  114. Selker, E. U., Cambareri, E. B., Jensen, B. C., and Haack, K. R. (1987) Cell, 51, 741–752.

    Article  PubMed  Google Scholar 

  115. Cambareri, E. B., Jensen, B. C., Schabtach, E., and Selker, E. U. (1989) Science, 244, 1571–1575.

    PubMed  Google Scholar 

  116. Rossignol, J.-L., and Faugeron, G. (1994) Experientia, 50, 307–317.

    Article  PubMed  Google Scholar 

  117. Goyon, C., and Faugeron, G. (1989) Mol. Cell. Biol., 9, 2818–2827.

    PubMed  Google Scholar 

  118. Selker, E. U. (1997) Trends Genet., 13, 296–301.

    Article  PubMed  Google Scholar 

  119. Rhounim, L., Rossignol, J. L., and Faugeron, G. (1992) EMBO J., 11, 4451–4457.

    PubMed  Google Scholar 

  120. Perkins, D. D., Metzenberg, R. L., Raju, N. B., Selker, E. U., and Barry, E. G. (1986) Genetics, 114, 791–817.

    PubMed  Google Scholar 

  121. Foss, H. M., Roberts, C. J., Claeys, K. M., and Selker, E. U. (1993) Science, 262, 1737–1741.

    PubMed  Google Scholar 

  122. Rhounim, L., Gregoire, A., Salama, S., and Faugeron, G. (1994) Curr. Genet., 26, 344–351.

    Article  PubMed  Google Scholar 

  123. Barry, C., Faugeron, G., and Rosignol, J. L. (1993) Proc. Natl. Acad. Sci. USA, 90, 4557–4561.

    PubMed  Google Scholar 

  124. Goyon, C., Barry, C., Gregoire, A., Faugeron, G., and Rossignol, J. L. (1996) Mol. Cell. Biol., 16, 3054–3065.

    PubMed  Google Scholar 

  125. Selker, E. U., Fritz, D. Y., and Singer, M. J. (1993) Science, 262, 1724–1728.

    PubMed  Google Scholar 

  126. Goyon, C., Nogueira, T. I. V., and Faugeron, G. (1994) J. Mol. Biol., 240, 42–51.

    Article  PubMed  Google Scholar 

  127. Malagnac, F., Wendel, B., Goyon, C., Faugeron, G., Zickler, D., Rossignol, J.-L., Noyer-Weidner, M., Vollmayr, P., Trautner, T. S., and Walter, J. (1997) Cell, 91, 281–290.

    Article  PubMed  Google Scholar 

  128. Chernov, A. V., Vollmayr, P., Walter, J., and Trautner, T. A. (1997) Biol. Chem., 378, 1467–1473.

    PubMed  Google Scholar 

  129. Malagnac, F., Gregoire, A., Goyon, C., Rossignol, J.-L., and Faugeron, G. (1999) Mol. Microbiol., 31, 331–338.

    Article  PubMed  Google Scholar 

  130. Kouzminova, E., and Selker, E. U. (2001) EMBO J., 20, 4309–4323.

    Article  PubMed  Google Scholar 

  131. Robertson, K. D., Uzvolgyi, E., Liang, G., Talmadge, C., Sumegi, J., Gonzales, F. A., and Jones, P. A. (1999) Nucleic Acids Res., 27, 2291–2298.

    Article  PubMed  Google Scholar 

  132. Glickman, J. F., Pavlovich, J. G., and Reich, N. O. (1997) J. Biol. Chem., 272, 17851–17867.

    Article  PubMed  Google Scholar 

  133. Gaudet, F., Talbot, D., Leonhardt, H., and Jaenisch, R. (1998) J. Biol. Chem., 273, 32725–32729.

    Article  PubMed  Google Scholar 

  134. Mertineit, C., Yoder, J. A., Taketo, T., Laird, D. W., Trasler, J. M., and Bestor, T. H. (1998) Development, 125, 889–897.

    PubMed  Google Scholar 

  135. Bigey, P., Ramchandani, S., Theberge, J., Araujo, F. D., and Szyf, M. (2000) Gene, 242, 407–418.

    Article  PubMed  Google Scholar 

  136. Deng, J., and Szyf, M. (1998) J. Biol. Chem., 273, 22869–22872.

    Article  PubMed  Google Scholar 

  137. Aapola, U., Maenpaa, K., Kaipia, A., and Petersen, P. (2004) Biochem. J., 380, 705–713.

    Article  PubMed  Google Scholar 

  138. MacLeod, A. R., Rouleau, J., and Szyf, M. (1995) J. Biol. Chem., 270, 11327–11337.

    Article  PubMed  Google Scholar 

  139. Rouleau, J., MacLeod, A. R., and Szyf, M. (1995) J. Biol. Chem., 270, 1595–1601.

    Article  PubMed  Google Scholar 

  140. Slack, A., Cervoni, N., Pinard, M., and Szyf, M. (1999) Eur. J. Biochem., 264, 191–199.

    Article  PubMed  Google Scholar 

  141. Vlasova, T. I., Kirnos, M. D., Demidenko, Z. N., and Vanyushin, B. F. (1994) Biochemistry (Moscow), 59, 1403–1410.

    Google Scholar 

  142. Pradhan, S., and Kim, G. D. (2002) EMBO J., 21, 779–788.

    Article  PubMed  Google Scholar 

  143. Ling, Y., Sankpal, U. T., Robertson, A. K., McNally, J. G., Karpova, T., and Robertson, K. D. (2004) Nucleic Acids Res., 32, 598–610.

    Article  PubMed  Google Scholar 

  144. Kang, E. S., Park, C. W., and Chung, J. H. (2001) Biochem. Biophys. Res. Commun., 289, 862–868.

    Article  PubMed  Google Scholar 

  145. Jackson, J. P., Lingroth, A. M., Cao, X., and Jacobsen, S. E. (2002) Nature, 416, 556–560.

    Article  PubMed  Google Scholar 

  146. Tamaru, H., and Selker, E. U. (2001) Nature, 414, 277–283.

    Article  PubMed  Google Scholar 

  147. Soppe, W. J. J., Jasencakova, Z., Houben, A., Kakutani, T., Meister, A., Huang, M. S., Jacobsen, S. E., Schubert, I., and Fransz, P. F. (2002) EMBO J., 21, 6549–6559.

    Article  PubMed  Google Scholar 

  148. Holler, M., Westin, G., Jiricny, J., and Schaffner, W. (1988) Genes Dev., 2, 1127–1135.

    PubMed  Google Scholar 

  149. MacLeod, D., Charlton, J., Mullins, J., and Bird, A. P. (1994) Genes Dev., 8, 2282–2292.

    PubMed  Google Scholar 

  150. Tatematsu, K. I., Yamazaki, T., and Ishikawa, F. (2000) Genes Cells, 5, 677–688.

    Article  PubMed  Google Scholar 

  151. Marinitch, D. V., Vorobyev, I. A., Holmes, J. A., Zakharchenko, N. S., Dyachenko, O. V., Buryanov, Ya. I., and Shevchuk, T. V. (2004) Biochemistry (Moscow), 69, 340–349.

    Article  Google Scholar 

  152. Luo, S., and Preuss, D. (2003) Proc. Natl. Acad. Sci. USA, 100, 11133–11138.

    Article  PubMed  Google Scholar 

  153. Costello, J. F., Fruhwald, M. C., Smiraglia, D. J., Rush, L. J., Robertson, G. P., Gao, X., Wright, F. A., Feramisco, J. D., Peltomaki, P., Lang, J. C., Schuller, D. E., Yu, L., Bloomfield, C. D., Caligiuri, M. A., Yates, A., Nishikawa, R., Huang, H.-J. S., Petrelli, N. J., Zhang, X., O’Dorisio, M. S., Held, W. A., Cavenee, W. K., and Plass, C. (2000) Nature Genet., 25, 132–138.

    Article  PubMed  Google Scholar 

  154. Shevchuk, T. V., and Buryanov, Ya. I. (1999) Bioorg. Khim., 25, 630–633.

    PubMed  Google Scholar 

  155. Esteller, M., Corn, P. G., Baylin, S. B., and Herman, J. G. (2001) Cancer Res., 61, 3225–3229.

    PubMed  Google Scholar 

  156. Kim, G. D., Ni, J., Kelesoglu, N., Roberts, R. J., and Pradhan, S. (2002) EMBO J., 21, 4183–4195.

    Article  PubMed  Google Scholar 

  157. Rountree, M. R., Bachman, K. E., and Baylin, S. B. (2000) Nat. Genet., 25, 269–277.

    Article  PubMed  Google Scholar 

  158. Fuks, F., Hurd, P. J., Deplus, R., and Kouzaridis, T. (2003) Nucleic Acids Res., 31, 2305–2312.

    Article  PubMed  Google Scholar 

  159. Di Croce, L., Raker, V. A., Corsaro, M., Fazi, F., Fanelli, M., Faretta, M., Fuks, F., Coco, F. L., Kouzaridis, T., Nervi, C., Minucci, S., and Pelicci, P. G. (2002) Science, 295, 1079–1082.

    Article  PubMed  Google Scholar 

  160. Robertson, A. K., Geiman, T. M., Sankpal, U. T., Hager, G. L., and Robertson, K. D. (2004) Biochem. Biophys. Res. Commun., 322, 110–118.

    Article  PubMed  Google Scholar 

  161. Tatematsu, K. I., Yamazaki, T., and Ishikawa, F. (2000) Genes Cells, 5, 677–688.

    Article  PubMed  Google Scholar 

  162. Kimura, H., and Shiota, K. (2003) J. Biol. Chem., 278, 4806–4812.

    Article  PubMed  Google Scholar 

  163. Carty, S. M., and Greenleaf, A. L. (2002) Mol. Cell. Proteomics, 1, 598–610.

    Article  PubMed  Google Scholar 

  164. Fuks, F., Burgers, W. A., Godin, N., Kasai, M., and Kouzaridis, T. (2001) EMBO J., 20, 2536–2544.

    Article  PubMed  Google Scholar 

  165. Bachman, K. E., Rountree, M. R., and Baylin, S. B. (2001) J. Biol. Chem., 276, 32282–32287.

    Article  PubMed  Google Scholar 

  166. Deplus, R., Brenner, C., Burgers, W. A., Putmans, P., Kouzaridis, T., de Launoit, Y., and Fuks, F. (2002) Nucleic Acids Res., 30, 3831–3838.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Pushchino Branch, Russian Academy of Sciences, pr. Nauki 6, 142290, Pushchino, Moscow Region, Russia

    Ya. I. Buryanov & T. V. Shevchuk

Authors
  1. Ya. I. Buryanov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T. V. Shevchuk
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ya. I. Buryanov.

Additional information

__________

Translated from Biokhimiya, Vol. 70, No. 7, 2005, pp. 885–899.

Original Russian Text Copyright © 2005 by Buryanov, Shevchuk.

This article was not published in the journal special issue devoted to the 70th anniversary of B. F. Vanyushin (Biochemistry (Moscow) (2005) 70, No. 5) because of limiting volume of the journal.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Buryanov, Y.I., Shevchuk, T.V. DNA Methyltransferases and Structural-Functional Specificity of Eukaryotic DNA Modification. Biochemistry (Moscow) 70, 730–742 (2005). https://doi.org/10.1007/s10541-005-0178-0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10541-005-0178-0

Key words

Search

Navigation