Skip to main content

Advertisement

SpringerLink
Log in

Adolescent Drinking and Motivated Decision-Making: A Cotwin-Control Investigation with Monozygotic Twins

  • Brief Communication
  • Published:
Behavior Genetics Aims and scope Submit manuscript

Abstract

The present study used a monozygotic (MZ) cotwin-control (CTC) design to investigate associations between alcohol use and performance on the Iowa gambling task (IGT) in a sample of 96 adolescents (half female). The MZ CTC design is well suited to shed light on whether poor decision-making, as reflected on IGT performance, predisposes individuals to abuse substances or is a consequence of use. Participants completed structural MRI scans as well, from which we derived gray matter volumes for cortical and subcortical regions involved in IGT performance and reduced in adolescents with problematic alcohol use. Drinking was associated with poorer task performance and with reduced volume of the left lateral orbital-frontal cortex. CTC analyses indicated that the former was due to differences between members of twin pairs in alcohol use (suggesting a causal effect of alcohol), whereas the latter was due to factors shared by twins (consistent with a pre-existing vulnerability for use). Although these preliminary findings warrant replication, they suggest that normative levels of alcohol use may diminish the quality of adolescent decision-making and thus have potentially important public health implications.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

References

  • Austin PC (2011) An introduction to propensity score methods for reducing the effects of confounding in observational studies. Multivar Behav Res 46(3):399–424

    Article  Google Scholar 

  • Bechara A, Martin EM (2004) Impaired decision making related to working memory deficits in individuals with substance addictions. Neuropsychology 18(1):152–162

    Article  PubMed  Google Scholar 

  • Bechara A, Damasio AR, Damasio H, Anderson SW (1994) Insensitivity to future consequences following damage to human prefrontal cortex. Cognition 50(1–3):7–15

    Article  PubMed  Google Scholar 

  • Bechara A, Tranel D, Damasio H (2000) Characterization of the decision-making deficit of patients with ventromedial prefrontal cortex lesions. Brain 123(Pt 11):2189–2202

    Article  PubMed  Google Scholar 

  • Bechara A, Dolan S, Denburg N, Hindes A, Anderson SW, Nathan PE (2001) Decision-making deficits, linked to a dysfunctional ventromedial prefrontal cortex, revealed in alcohol and stimulant abusers. Neuropsychologia 39(4):376–389

    Article  PubMed  Google Scholar 

  • Begg MD, Parides MK (2003) Separation of individual-level and cluster-level covariate effects in regression analysis of correlated data. Stat Med 22(16):2591–2602

    Article  PubMed  Google Scholar 

  • Bolla KI, Eldreth DA, London ED, Kiehl KA, Mouratidis M, Contoreggi C, Matochik JA, Kurian V, Cadet JL, Kimes AS, Funderburk FR, Ernst M (2003) Orbitofrontal cortex dysfunction in abstinent cocaine abusers performing a decision-making task. Neuroimage 19(3):1085–1094

    Article  PubMed Central  PubMed  Google Scholar 

  • Bowman CH, Turnbull OH (2003) Real versus facsimile reinforcers on the Iowa Gambling Task. Brain Cogn 53(2):207–210

    Article  PubMed  Google Scholar 

  • Camerer CF, Hogarth RM (1999) The effects of financial incentives in experiments: a review and capital-labor-production framework. J Risk Uncertain 19(1–3):7–42

    Article  Google Scholar 

  • Camille N, Coricelli G, Sallet J, Pradat-Diehl P, Duhamel JR, Sirigu A (2004) The involvement of the orbitofrontal cortex in the experience of regret. Science 304(5674):1167–1170

    Article  PubMed  Google Scholar 

  • Cantrell H, Finn PR, Rickert ME, Lucas J (2008) Decision making in alcohol dependence: insensitivity to future consequences and comorbid disinhibitory psychopathology. Alcohol Clin Exp Res 32(8):1398–1407

    Article  PubMed Central  PubMed  Google Scholar 

  • Casey BJ, Jones RM (2010) Neurobiology of the adolescent brain and behavior: implications for substance use disorders. J Am Acad Child Adolesc Psychiatry 49(12):1189–1201 quiz 1285

    PubMed Central  PubMed  Google Scholar 

  • Cheetham A, Allen NB, Whittle S, Simmons JG, Yucel M, Lubman DI (2012) Orbitofrontal volumes in early adolescence predict initiation of cannabis use: a 4-year longitudinal and prospective study. Biol Psychiatry 71(8):684–692

    Article  PubMed  Google Scholar 

  • Clark JJ, Nasrallah NA, Hart AS, Collins AL, Bernstein IL, Phillips PE (2012) Altered risk-based decision making following adolescent alcohol use results from an imbalance in reinforcement learning in rats. PLoS One 7(5):e37357

    Article  PubMed Central  PubMed  Google Scholar 

  • Crews FT, Braun CJ, Hoplight B, Switzer RC, Knapp DJ (2000) Binge ethanol consumption causes differential brain damage in young adolescent rats compared with adult rats. Alcohol-Clin Exp Res 24(11):1712–1723

    Article  PubMed  Google Scholar 

  • Crone EA, van der Molen MW (2004) Developmental changes in real life decision making: performance on a gambling task previously shown to depend on the ventromedial prefrontal cortex. Dev Neuropsychol 25(3):251–279

    Article  PubMed  Google Scholar 

  • Cukrowicz KC, Taylor J, Schatschneider C, Iacono WG (2006) Personality differences in children and adolescents with attention-deficit/hyperactivity disorder, conduct disorder, and controls. J Child Psychol Psychiatry 47(2):151–159

    Article  PubMed  Google Scholar 

  • De Bellis MD, Clark DB, Beers SR, Soloff PH, Boring AM, Hall J, Kersh A, Keshavan MS (2000) Hippocampal volume in adolescent-onset alcohol use disorders. Am J Psychiatry 157(5):737–744

    Article  PubMed  Google Scholar 

  • De Bellis MD, Narasimhan A, Thatcher DL, Keshavan MS, Soloff P, Clark DB (2005) Prefrontal cortex, thalamus, and cerebellar volumes in adolescents and young adults with adolescent-onset alcohol use disorders and comorbid mental disorders. Alcohol Clin Exp Res 29(9):1590–1600

    Article  PubMed  Google Scholar 

  • Dom G, De Wilde B, Hulstijn W, van den Brink W, Sabbe B (2006) Decision-making deficits in alcohol-dependent patients with and without comorbid personality disorder. Alcohol Clin Exp Res 30(10):1670–1677

    Article  PubMed  Google Scholar 

  • Ernst M, Grant SJ, London ED, Contoreggi CS, Kimes AS, Spurgeon L (2003) Decision making in adolescents with behavior disorders and adults with substance abuse. Am J Psychiatry 160(1):33–40

    Article  PubMed  Google Scholar 

  • Ernst M, Luckenbaugh DA, Moolchan ET, Temple VA, Jenness J, Korelitz KE, London ED, Kimes AS (2010) Decision-making and facial emotion recognition as predictors of substance-use initiation among adolescents. Addict Behav 35(3):286–289

    Article  PubMed  Google Scholar 

  • Fairchild G, van Goozen SH, Stollery SJ, Aitken MR, Savage J, Moore SC, Goodyer IM (2009) Decision making and executive function in male adolescents with early-onset or adolescence-onset conduct disorder and control subjects. Biol Psychiatry 66(2):162–168

    Article  PubMed Central  PubMed  Google Scholar 

  • Fischl B, Sereno MI, Dale AM (1999) Cortical surface-based analysis. II: inflation, flattening, and a surface-based coordinate system. Neuroimage 9(2):195–207

    Article  PubMed  Google Scholar 

  • Fischl B, Salat DH, Busa E, Albert M, Dieterich M, Haselgrove C, van der Kouwe A, Killiany R, Kennedy D, Klaveness S, Montillo A, Makris N, Rosen B, Dale AM (2002) While brain segmentation: automated labeling of neuroanatomical structures in the human brain. Neuron 33(3):341–355

    Article  PubMed  Google Scholar 

  • Fischl B, van der Kouwe A, Destrieux C, Halgren E, Segonne F, Salat DH, Busa E, Seidman LJ, Goldstein J, Kennedy D, Caviness V, Makris N, Rosen B, Dale AM (2004) Automatically parcellating the human cerebral cortex. Cereb Cortex 14(1):11–22

    Article  PubMed  Google Scholar 

  • George S, Rogers RD, Duka T (2005) The acute effect of alcohol on decision making in social drinkers. Psychopharmacology 182(1):160–169

    Article  PubMed  Google Scholar 

  • Goudriaan AE, Oosterlaan J, de Beurs E, van den Brink W (2005) Decision making in pathological gambling: a comparison between pathological gamblers, alcohol dependents, persons with Tourette syndrome, and normal controls. Brain Res Cogn Brain Res 23(1):137–151

    Article  PubMed  Google Scholar 

  • Goudriaan AE, Grekin ER, Sher KJ (2007) Decision making and binge drinking: a longitudinal study. Alcohol Clin Exp Res 31(6):928–938

    Article  PubMed Central  PubMed  Google Scholar 

  • Gupta R, Duff MC, Denburg NL, Cohen NJ, Bechara A, Tranel D (2009) Declarative memory is critical for sustained advantageous complex decision-making. Neuropsychologia 47(7):1686–1693

    Article  PubMed Central  PubMed  Google Scholar 

  • Hanson KL, Luciana M, Sullwold K (2008) Reward-related decision-making deficits and elevated impulsivity among MDMA and other drug users. Drug Alcohol Depend 96(1–2):99–110

    Article  PubMed Central  PubMed  Google Scholar 

  • Hermann D, Lemenager T, Gelbke J, Welzel H, Skopp G, Mann K (2009) Decision making of heavy cannabis users on the Iowa gambling task: stronger association with THC of hair analysis than with personality traits of the Tridimensional Personality Questionnaire. Eur Addict Res 15(2):94–98

    Article  PubMed  Google Scholar 

  • Hertwig R, Ortmann A (2001) Experimental practices in economics: a methodological challenge for psychologists? Behav Brain Sci 24(3):383–403 discussion 403-351

    PubMed  Google Scholar 

  • Hicks BM, Schalet BD, Malone SM, Iacono WG, McGue M (2011) Psychometric and genetic architecture of substance use disorder and behavioral disinhibition measures for gene association studies. Behav Genet 41(4):459–475

    Article  PubMed Central  PubMed  Google Scholar 

  • Hill SY, Wang S, Kostelnik B, Carter H, Holmes B, McDermott M, Zezza N, Stiffler S, Keshavan MS (2009) Disruption of orbitofrontal cortex laterality in offspring from multiplex alcohol dependence families. Biol Psychiatry 65(2):129–136

    Article  PubMed Central  PubMed  Google Scholar 

  • Hiller-Sturmhofel S, Swartzwelder HS (2004) Alcohol’s effects on the adolescent brain—what can be learned from animal models. Alcohol Res Health 28(4):213–221

    Google Scholar 

  • Hobson CW, Scott S, Rubia K (2011) Investigation of cool and hot executive function in ODD/CD independently of ADHD. J Child Psychol Psychiatry 52(10):1035–1043

    Article  PubMed  Google Scholar 

  • Iacono WG, McGue M (2002) Minnesota twin family study. Twin Res 5(5):482–487

    Article  PubMed  Google Scholar 

  • Iacono WG, Carlson SR, Taylor J, Elkins IJ, McGue M (1999) Behavioral disinhibition and the development of substance-use disorders: findings from the Minnesota twin family study. Dev Psychopathol 11(4):869–900

    Article  PubMed  Google Scholar 

  • Imai K, Ratkovic M (2013) Covariate balancing propensity score. J R Stat Soc B 76(1):243–246

    Article  Google Scholar 

  • Jacobus J, Tapert SF (2013) Neurotoxic effects of alcohol in adolescence. Annu Rev Clin Psychol 9:703–721

    Article  PubMed  Google Scholar 

  • Jenkinson M, Bannister P, Brady M, Smith S (2002) Improved optimization for the robust and accurate linear registration and motion correction of brain images. Neuroimage 17(2):825–841

    Article  PubMed  Google Scholar 

  • Johnson W, McGue M, Iacono WG (2006) Genetic and environmental influences on academic achievement trajectories during adolescence. Dev Psychol 42(3):514–532

    Article  PubMed  Google Scholar 

  • Johnson W, McGue M, Iacono WG (2007) How parents influence school grades: hints from a sample of adoptive and biological families. Learn Individ Differ 17(3):201–219

    Article  PubMed Central  PubMed  Google Scholar 

  • Johnson CA, Xiao L, Palmer P, Sun P, Wang Q, Wei Y, Jia Y, Grenard JL, Stacy AW, Bechara A (2008) Affective decision-making deficits, linked to a dysfunctional ventromedial prefrontal cortex, revealed in 10th grade Chinese adolescent binge drinkers. Neuropsychologia 46(2):714–726

    Article  PubMed Central  PubMed  Google Scholar 

  • Johnston LD, O’Malley PM, Bachman JG, Schulenberg J (2011) Marijuana use continues to rise among US teens, while alcohol use hits historic lows. University of Michigan News Service, Ann Arbor

    Google Scholar 

  • Keyes MA, Malone SM, Elkins IJ, Legrand LN, McGue M, Iacono WG (2009) The enrichment study of the Minnesota twin family study: increasing the yield of twin families at high risk for externalizing psychopathology. Twin Res Hum Genet 12(5):489

    Article  PubMed Central  PubMed  Google Scholar 

  • Kim YT, Lee SJ, Kim SH (2006) Effects of the history of conduct disorder on the Iowa gambling tasks. Alcohol Clin Exp Res 30(3):466–472

    Article  PubMed  Google Scholar 

  • Kosten TA, Rounsaville BJ (1992) Sensitivity of psychiatric diagnosis based on the best estimate procedure. Am J Psychiatry 149(9):1225–1227

    PubMed  Google Scholar 

  • Kringelbach ML, Rolls ET (2004) The functional neuroanatomy of the human orbitofrontal cortex: evidence from neuroimaging and neuropsychology. Prog Neurobiol 72(5):341–372

    Article  PubMed  Google Scholar 

  • Laakso MP, Gunning-Dixon F, Vaurio O, Repo-Tiihonen E, Soininen H, Tiihonen J (2002) Prefrontal volumes in habitually violent subjects with antisocial personality disorder and type 2 alcoholism. Psychiatry Res 114(2):95–102

    Article  PubMed  Google Scholar 

  • Le Berre AP, Rauchs G, La Joie R, Mezenge F, Boudehent C, Vabret F, Segobin S, Viader F, Allain P, Eustache F, Pitel AL, Beaunieux H (2014) Impaired decision-making and brain shrinkage in alcoholism. Eur Psychiatry 29(3):125–133

    Article  PubMed  Google Scholar 

  • Leckman JF, Scholomskas D, Thompson WD, Belanger A, Weisman MM (1982) Best estimate of lifetime psychiatric diagnosis: a methodological study. Arch Gen Psychiatry 39(8):879–883

    Article  PubMed  Google Scholar 

  • Lovallo WR, Yechiam E, Sorocco KH, Vincent AS, Collins FL (2006) Working memory and decision-making biases in young adults with a family history of alcoholism: studies from the Oklahoma family health patterns project. Alcohol Clin Exp Res 30(5):763–773

    Article  PubMed Central  PubMed  Google Scholar 

  • Luciana M, Collins PF (2012) Incentive motivation, cognitive control, and the adolescent brain: is it time for a paradigm shift? Child Dev Perspect 6(4):392–399

    PubMed Central  PubMed  Google Scholar 

  • Luciana M, Wahlstrom D, Porter JN, Collins PF (2012) Dopaminergic modulation of incentive motivation in adolescence: age-related changes in signaling, individual differences, and implications for the development of self-regulation. Dev Psychol 48(3):844

    Article  PubMed Central  PubMed  Google Scholar 

  • Makris N, Oscar-Berman M, Jaffin SK, Hodge SM, Kennedy DN, Caviness VS, Marinkovic K, Breiter HC, Gasic GP, Harris GJ (2008) Decreased volume of the brain reward system in alcoholism. Biol Psychiatry 64(3):192–202

    Article  PubMed Central  PubMed  Google Scholar 

  • Markwiese BJ, Acheson SK, Levin ED, Wilson WA, Swartzwelder HS (1998) Differential effects of ethanol on memory in adolescent and adult rats. Alcohol Clin Exp Res 22(2):416–421

    Article  PubMed  Google Scholar 

  • McGue M, Keyes M, Sharma A, Elkins I, Legrand L, Johnson W, Iacono WG (2007) The environments of adopted and non-adopted youth: evidence on range restriction from the sibling interaction and behavior study (SIBS). Behav Genet 37(3):449–462

    Article  PubMed  Google Scholar 

  • McGue M, Osler M, Christensen K (2010) Causal inference and observational research: the utility of twins. Perspect Psychol Sci 5(5):546–556

    Article  PubMed Central  PubMed  Google Scholar 

  • Medina KL, McQueeny T, Nagel BJ, Hanson KL, Schweinsburg AD, Tapert SF (2008) Prefrontal cortex volumes in adolescents with alcohol use disorders: unique gender effects. Alcohol Clin Exp Res 32(3):386–394

    Article  PubMed Central  PubMed  Google Scholar 

  • Monti PM, Miranda R Jr, Nixon K, Sher KJ, Swartzwelder HS, Tapert SF, White A, Crews FT (2005) Adolescence: booze, brains, and behavior. Alcohol Clin Exp Res 29(2):207–220

    Article  PubMed  Google Scholar 

  • Moreno M, Estevez AF, Zaldivar F, Montes JM, Gutierrez-Ferre VE, Esteban L, Sanchez-Santed F, Flores P (2012) Impulsivity differences in recreational cannabis users and binge drinkers in a university population. Drug Alcohol Depend 124(3):355–362

    Article  PubMed  Google Scholar 

  • Nagel BJ, Schweinsburg AD, Phan V, Tapert SF (2005) Reduced hippocampal volume among adolescents with alcohol use disorders without psychiatric comorbidity. Psychiatry Res 139(3):181–190

    Article  PubMed Central  PubMed  Google Scholar 

  • Nasrallah NA, Clark JJ, Collins AL, Akers CA, Phillips PE, Bernstein IL (2011) Risk preference following adolescent alcohol use is associated with corrupted encoding of costs but not rewards by mesolimbic dopamine. Proc Natl Acad Sci USA 108(13):5466–5471

    Article  PubMed Central  PubMed  Google Scholar 

  • Neuhaus JM, Kalbfleisch JD (1998) Between- and within-cluster covariate effects in the analysis of clustered data. Biometrics 54(2):638–645

    Article  PubMed  Google Scholar 

  • Nixon K, Crews FT (2002) Binge ethanol exposure decreases neurogenesis in adult rat hippocampus. J Neurochem 83(5):1087–1093

    Article  PubMed  Google Scholar 

  • Obernier JA, White AM, Swartzwelder HS, Crews FT (2002) Cognitive deficits and CNS damage after a 4-day binge ethanol exposure in rats. Pharmacol Biochem Behav 72(3):521–532

    Article  PubMed  Google Scholar 

  • Oliva EM, Keyes M, Iacono WG, McGue M (2012) Adolescent substance use groups: antecedent and concurrent personality differences in a longitudinal study. J Pers 80(3):769–793

    Article  PubMed Central  PubMed  Google Scholar 

  • Rabe-Hesketh S, Skrondal A, Pickles A (2004) Generalized multilevel structural equation modeling. Psychometrika 69(2):167–190

    Article  Google Scholar 

  • Reich W (2000) Diagnostic interview for children and adolescents (DICA). J Am Acad Child Adolesc Psychiatry 39:59–66

    Article  PubMed  Google Scholar 

  • Robins LM, Baber T, Cottler LB (1987) Composite International Diagnostic Interview: Expanded Substance Abuse Module. Authors, St. Louis

    Google Scholar 

  • Rosenbaum PR, Rubin DB (1983) The central role of the propensity score in observational studies for causal effects. Biometrika 70(1):41–55

    Article  Google Scholar 

  • Rubin DB (2001) Using propensity scores to help design observational studies: application to the tobacco litigation. Health Serv Outcomes Res Method 2(3–4):169–188

    Article  Google Scholar 

  • Rutter M, Pickles A, Murray R, Eaves LJ (2001) Testing hypotheses on specific causal effects on behavior. Psychol Bull 127(3):291–324

    Article  PubMed  Google Scholar 

  • Schoenbaum G, Roesch MR, Stalnaker TA (2006) Orbitofrontal cortex, decision-making and drug addiction. Trends Neurosci 29(2):116–124

    Article  PubMed Central  PubMed  Google Scholar 

  • Shors TJ, Miesegaes G, Beylin A, Zhao MR, Rydel T, Gould E (2001) Neurogenesis in the adult is involved in the formation of trace memories. Nature 410(6826):372–376

    Article  PubMed  Google Scholar 

  • Silvers JM, Tokunaga S, Mittleman G, O’Buckley T, Morrow AL, Matthews DB (2006) Chronic intermittent ethanol exposure during adolescence reduces the effect of ethanol challenge on hippocampal allopregnanolone levels and Morris water maze task performance. Alcohol 39(3):151–158

    Article  PubMed  Google Scholar 

  • Sircar R, Sircar D (2005) Adolescent rats exposed to repeated ethanol treatment show lingering behavioral impairments. Alcohol-Clin Exp Res 29(8):1402–1410

    Article  PubMed  Google Scholar 

  • Sled JG, Zijdenbos AP, Evans AC (1998) A nonparametric method for automatic correction of intensity nonuniformity in MRI data. IEEE Trans Med Imaging 17(1):87–97

    Article  PubMed  Google Scholar 

  • Snijders TAB, Bosker RJ (1999) Multilevel analysis: an introduction to basic and advanced multilevel modelingSage Publications. Thousand Oaks, CA

    Google Scholar 

  • Spinella M (2007) Normative data and a short form of the Barratt impulsiveness scale. Int J Neurosci 117(3):359–368

    Article  PubMed  Google Scholar 

  • Steinberg L (2010) A dual systems model of adolescent risk-taking. Dev Psychobiol 52(3):216–224

    PubMed  Google Scholar 

  • Stuart EA (2010) Matching methods for causal inference: a review and a look forward. Stat Sci 25(1):1

    Article  PubMed Central  PubMed  Google Scholar 

  • Stuart EA, Marcus SM, Horvitz-Lennon MV, Gibbons RD, Normand S-LT (2009) Using non-experimental data to estimate treatment effects. Psychiatr Ann 39(7):41451

    Article  PubMed Central  PubMed  Google Scholar 

  • Tanabe J, Thompson L, Claus E, Dalwani M, Hutchison K, Banich MT (2007) Prefrontal cortex activity is reduced in gambling and nongambling substance users during decision-making. Hum Brain Mapp 28(12):1276–1286

    Article  PubMed  Google Scholar 

  • Taylor J, Iacono WG, McGue M (2000) Evidence for a genetic etiology of early-onset delinquency. J Abnorm Psychol 109(4):634–643

    Article  PubMed  Google Scholar 

  • Team RDC (2013) R: a language and environment for statistical computing. R Foundation for Statistical Computing, Vienna

    Google Scholar 

  • Tellegen A, Waller NG (2008) Exploring personality through test construction: development of the multidimensional personality questionnaire [References]. The SAGE handbook of personality theory and assessment: personality measurement and testing, vol 2. Sage Publications Inc., Thousand Oaks, pp 261–292

    Chapter  Google Scholar 

  • Tranel D, Bechara A, Denburg NL (2002) Asymmetric functional roles of right and left ventromedial prefrontal cortices in social conduct, decision-making, and emotional processing. Cortex 38(4):589–612

    Article  PubMed  Google Scholar 

  • Tsuchida A, Doll BB, Fellows LK (2010) Beyond reversal: a critical role for human orbitofrontal cortex in flexible learning from probabilistic feedback. J Neurosci 30(50):16868–16875

    Article  PubMed  Google Scholar 

  • Urošević S, Collins P, Muetzel R, Lim K, Luciana M (2012) Longitudinal changes in behavioral approach system sensitivity and brain structures involved in reward processing during adolescence. Dev Psychol 48(5):1488

    Article  PubMed Central  PubMed  Google Scholar 

  • Verdejo-Garcia AJ, Perales JC, Perez-Garcia M (2007) Cognitive impulsivity in cocaine and heroin polysubstance abusers. Addict Behav 32(5):950–966

    Article  PubMed  Google Scholar 

  • Wechsler D (1999) Wechsler abbreviated scale of intelligence. The Psychological Corporation, San Antonio

    Google Scholar 

  • Welch KA, Carson A, Lawrie SM (2013) Brain structure in adolescents and young adults with alcohol problems: systematic review of imaging studies. Alcohol Alcohol 48(4):433–444

    Article  PubMed  Google Scholar 

  • Xiao L, Bechara A, Grenard LJ, Stacy WA, Palmer P, Wei Y, Jia Y, Fu X, Johnson CA (2009) Affective decision-making predictive of Chinese adolescent drinking behaviors. J Int Neuropsychol Soc 15(4):547–557

    Article  PubMed Central  PubMed  Google Scholar 

  • Xiao L, Bechara A, Gong Q, Huang X, Li X, Xue G, Wong S, Lu ZL, Palmer P, Wei Y, Jia Y, Johnson CA (2012) Abnormal affective decision making revealed in adolescent binge drinkers using a functional magnetic resonance imaging study. Psychol Addict Behav 27(2):443–454

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

The authors thank Chrissy Evenson for her conscientiousness, dedication, and great skill in coordinating AdBrain and Lyric Jorgenson for graciously assisting with MRI scans. This research was supported by National Institutes of Health grants R21 AA 017314, R37 DA 05147, and R01 DA036216, as well as P30 NS057091 and P30 NS076408 for “Institutional Center Cores for Advanced Neuroimaging” at the Center for Magnetic Resonance Research.

Conflict of Interest

The authors (Malone, Luciana, Wilson, Sparks, Hunt, Thomas, and Iacono) indicate that they have no conflicts of interest.

Human and Animal Rights and Informed Consent

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2000. Informed consent was obtained from all patients for being included in the study.

Author information

Authors and Affiliations

  1. Department of Psychology, University of Minnesota – Twin Cities, Minneapolis, MN, 55455, USA

    Stephen M. Malone, Monica Luciana, Sylia Wilson, Jordan C. Sparks & William G. Iacono

  2. Institute of Child Development, University of Minnesota – Twin Cities, Minneapolis, MN, 55455, USA

    Ruskin H. Hunt & Kathleen M. Thomas

  3. University of Minnesota, 75 East River Road, Minneapolis, MN, 55105, USA

    Stephen M. Malone

Authors
  1. Stephen M. Malone
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Monica Luciana
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Sylia Wilson
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jordan C. Sparks
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Ruskin H. Hunt
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Kathleen M. Thomas
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. William G. Iacono
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Stephen M. Malone.

Additional information

Edited by Yoon-Mi Hur.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Malone, S.M., Luciana, M., Wilson, S. et al. Adolescent Drinking and Motivated Decision-Making: A Cotwin-Control Investigation with Monozygotic Twins. Behav Genet 44, 407–418 (2014). https://doi.org/10.1007/s10519-014-9651-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10519-014-9651-0

Keywords

Search

Navigation