Type 2 diabetes mellitus develops due to a combination of genetic and environmental factors. C57BL/6 mice prone to obesity and leptin resistance were kept on a high-fat diet for 21 weeks. The animals showed a significant increase in fasting and postprandial glucose levels and body weight, the development of insulin resistance, and by week 18, an increase in the serum TNFα level. Metformin therapy at a dose of 250 mg/kg was effective against the background of disturbances in carbohydrate metabolism: animals showed a significant decrease in insulin resistance and TNFα level.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 176, No. 10, pp. 460-464, October, 2023
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Borozdina, N.A., Shaikhutdinova, E.R., Slashcheva, G.A. et al. Characterization of Risk Factors for Modeling of Type 2 Diabetes Mellitus Induced by a High-Fat Diet in C57BL/6 Mice. Bull Exp Biol Med 176, 461–465 (2024). https://doi.org/10.1007/s10517-024-06047-6
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DOI: https://doi.org/10.1007/s10517-024-06047-6