Molecular genetic analysis of polymorphic variants of serotonin receptor genes (HTR2C and HTR2A) was performed in 89 healthy medical students and regulatory and adaptive capacities were determined by cardiorespiratory synchronism. The relationship of serotonin receptor gene polymorphisms and the regulatory and adaptive capabilities of the body were revealed. The highly active *G allele and *G/*G genotype of the serotonin receptor HTR2C gene and the heterozygous *A/*G genotype of the serotonin receptor HTR2A gene are associated with “good” regulatory and adaptive capacities. The low-active *C allele of the serotonin receptor HTR2C gene is associated with “low” regulatory and adaptive capacities.
Similar content being viewed by others
References
Polischuk VV, Polischuk SV. Perfection of the method of the quantitative estimation of the regulatory and adaptive capacities of the organism as the way to the objective characteristic of the adaptation process. Kuban. Nauch. Med. Vestnik. 2015;(2):114-116. Russian.
Shkirya TV, Usatikov SV, Pokrovskii VM, Polischuk LV. Certificate of State Registration of Computer Programs RU No. 2015660661. A program for express diagnostics of the level of the regulatory and adaptive status of the organism in the system of determining human cardio-respiratory synchronism. Stated August 26, 2015. Date October 05, 2015.
Pokrovsky VM, Polishchuk LV, Polischuk SV. The methodology of assessing the effectiveness of the therapy. Res. Result Pharmacol. 2017;3(2):91-100. doi: https://doi.org/10.18413/2313-8971-2017-3-2-91-100
Livanova IA, Gumerova OV. Relationship between the serotonin system and the nervous processes. Vestn. Bashkir. Gos. Ped. Univer. M. Akmully. 2020;(2):25-27. Russian.
Zhur KV, Mosse IB, Kilchevsky AV, Kukhtsinskaya LV, Charykova IA. Associations of polymorphic variants of a number of neurotransmitter system genes with athlete psychophysiological characteristics. Mol. Priklad. Genet. 2019;26:136-144. Russian.
Wang H, Hu L, Liu C, Su Z, Wang L, Pan G, Guo Y, He J. 5-HT2 receptors mediate functional modulation of GABAa receptors and inhibitory synaptic transmissions in human iPS-derived neurons. Sci. Rep. 2016;6:20033. doi: https://doi.org/10.1038/srep20033
Golimbet VE, Garakh ZhV, Korovaitseva GI, Lezheiko TV, Zaitseva YuS, Gurovich IYa, Shmukler AB, Rodionov GI, Strelets VB. Association of the brain-derived neurotrophic factor and serotonin transporter genes with parameters of the early components of event-related potentials on passive word perception. Neurosci. Behav. Phys. 2017;47:1140-1146. doi: https://doi.org/10.1007/s11055-017-0521-0
Timofeeva MA, Maliuchenko NV, Kulikova MA, Shleptsova VA, Shchegolkova YuA, Vediakov AM, Tonevitsky AG. Prospects of studying the polymorphisms of key genes of neurotransmitter systems: II. the serotonergic system. Hum. Physiol. 2008;34(3):363-372. doi: https://doi.org/10.1134/S0362119708030158
Sanders-Bush E, Fentress H, Hazelwood L. Serotonin 5-ht2 receptors: molecular and genomic diversity. Mol Interv. 2003;3(6):319-30. doi: https://doi.org/10.1124/mi.3.6.319
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 175, No. 4, pp. 415-418, April, 2023
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Kashina, Y.V., Cherednik, I.L., Pokrovsky, V.M. et al. Association of Serotonin Receptor Gene Polymorphisms with Regulatory and Adaptive Capacities of Medical Students. Bull Exp Biol Med 175, 424–426 (2023). https://doi.org/10.1007/s10517-023-05878-z
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-023-05878-z