We studied the biodistribution of 68Ga-NODA-aminoglucose (68Ga-NODA-AG) in normal mice and mice with experimental model of colon adenocarcinoma tumor. It was shown that 68Ga-NODA-aminoglucose was retained in the tumor for 3 h after injection and demonstrated high level of accumulation in the tumor. Rapid clearance of radioactivity from other organs was observed. The results suggest that 68Ga-NODA-aminoglucose is a promising agent for tumor visualization by positron emission tomography.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 170, No. 9, pp. 340-344, September, 2020
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Tishchenko, V.K., Petriev, V.M., Mikhailovskaya, A.A. et al. Biodistribution of 68Ga-NODA-Aminoglucose in Intact and Tumor-Bearing Mice. Bull Exp Biol Med 170, 345–349 (2021). https://doi.org/10.1007/s10517-021-05064-z
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DOI: https://doi.org/10.1007/s10517-021-05064-z