Chimeric gp130 receptors were produced to study the role of three fibronectin type III-like domains in activation of gp130 receptor machinery. The ligand-induced dimerization of gp130 was sufficient to trigger STAT3 signaling pathway. These findings can be used as the basis in designing novel therapeutic gp130 inhibitors.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 161, No. 1, pp. 84-87, January 2016
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Stepanov, A.V., Rybinets, A.S., Dronina, M.A. et al. Study of Fibronectin Type III-Like Domains Role in Activation of gp130 Receptor. Bull Exp Biol Med 161, 72–74 (2016). https://doi.org/10.1007/s10517-016-3348-8
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DOI: https://doi.org/10.1007/s10517-016-3348-8