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Whether Modern Cell Technologies Can Break Down Biological Limitations of Tissue-Specific Regeneration of the Myocardium

  • Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

The paper reviews modern concepts of physiological and reparative regeneration of the myocardium as a highly specific and highly differentiated tissue system. Special attention was given to evaluation of the proliferative potential of cardiomyocytes, in particular, to the existence of a population of resident cardiac stem cells in the myocardium. Modern approaches to replenishment of massive cardiomyocyte loss via transplantation and transdifferentiation of adult and embryonic stem cells are discussed and the possibilities of using cell technologies for induction of tissue-specific regeneration of the myocardium are analyzed.

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  1. Research Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia

    L. M. Nepomnyashchikh, E. L. Lushnikova & D.V. Goldshtein

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  1. L. M. Nepomnyashchikh
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  2. E. L. Lushnikova
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  3. D.V. Goldshtein
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Correspondence to L. M. Nepomnyashchikh.

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Translated from Kletochnye Tekhnologii v Biologii i Meditsine, No. 2, pp. 63–74, 2005

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Nepomnyashchikh, L.M., Lushnikova, E.L. & Goldshtein, D. Whether Modern Cell Technologies Can Break Down Biological Limitations of Tissue-Specific Regeneration of the Myocardium. Bull Exp Biol Med 139, 481–490 (2005). https://doi.org/10.1007/s10517-005-0328-9

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