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New prospects of cancer therapy based on pyroptosis and pyroptosis inducers

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Abstract

Pyroptosis is a gasdermin-mediated programmed cell death (PCD) pathway. It differs from apoptosis because of the secretion of inflammatory molecules. Pyroptosis is closely associated with various malignant tumors. Recent studies have demonstrated that pyroptosis can either inhibit or promote the development of malignant tumors, depending on the cell type (immune or cancer cells) and duration and severity of the process. This review summarizes the molecular mechanisms of pyroptosis, its relationship with malignancies, and focuses on current pyroptosis inducers and their significance in cancer treatment. The molecules involved in the pyroptosis signaling pathway could serve as therapeutic targets for the development of novel drugs for cancer therapy. In addition, we analyzed the potential of combining pyroptosis with conventional anticancer techniques as a promising strategy for cancer treatment.

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Acknowledgements

We thank Bullet Edits Limited for the linguistic editing and proofreading of the manuscript.

Funding

This study was financially supported by the National Natural Science Foundation of China (grant No. 81803916 and 82374223) and Natural Science Foundation of Jiangsu Province (grant No. BK20180128).

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  1. Qiaoyun Chen and Yuxiang Sun contributed equally to this article.

Authors and Affiliations

  1. China Pharmaceutical University Nanjing Drum Tower Hospital, Nanjing, 210008, China

    Qiaoyun Chen, Siliang Wang & Jingyan Xu

  2. Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210008, China

    Qiaoyun Chen, Siliang Wang & Jingyan Xu

  3. Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, 225000, China

    Yuxiang Sun

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Q Chen and Y Sun conceived the structure of manuscript and drafted the manuscript; Q Chen, S Wang and J Xu discussed and revised the manuscript. All authors read and approved final manuscript.

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Chen, Q., Sun, Y., Wang, S. et al. New prospects of cancer therapy based on pyroptosis and pyroptosis inducers. Apoptosis 29, 66–85 (2024). https://doi.org/10.1007/s10495-023-01906-5

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