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OPRM1 and Diagnosis-Related Posttraumatic Stress Disorder in Binge-Drinking Patients Living with HIV

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Abstract

Posttraumatic stress disorder (PTSD) has been linked to numerous negative outcomes in persons living with HIV (PLH) and there is evidence that PTSD symptoms may play a role in maintaining alcohol use problems. The opioid receptor mu-1 (OPRM1) gene may play a role in both PTSD and alcohol use. We examined the association between PTSD and drinking motives as well as variation in the OPRM1 as a predictor of both PTSD and drinking motives in a sample of 201 PLH reporting recent binge drinking. Self-reported PTSD symptom severity was significantly associated with drinking motives for coping, enhancement, and socialization. OPRM1 variation was associated with decreased PTSD symptom severity as well as enhancement motives for drinking.

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Acknowledgments

This research was funded by a 2008 developmental grant from the Lifespan/Tufts/Brown Center for AIDS Research. The project described was supported by Grant Number P30AI042853 from the National Institute Of Allergy And Infectious Diseases. Content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute Of Allergy And Infectious Diseases or the National Institute of Health. Dr. Nugent is supported by US-NIMH K01 MH087240. Work was supported by 1S10RR023457 and Shared equipment grants (ShEEP) from the Medical Research Service of the Department of Veteran Affairs, awarded to J. E. McGeary. This material is the result of work supported with resources and the use of facilities at the Providence VA Medical Center.

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Authors and Affiliations

  1. Division of Behavioral Genetics, Department of Psychiatry, Rhode Island Hospital, Providence, RI, USA

    Nicole R. Nugent, Valerie S. Knopik & John E. McGeary

  2. Bradley/Hasbro Research Center, Rhode Island Hospital, Providence, RI, USA

    Nicole R. Nugent, Larry Brown & Valerie S. Knopik

  3. Department of Psychiatry and Human Behavior, Alpert Brown Medical School, Providence, RI, USA

    Nicole R. Nugent, Larry Brown, Valerie S. Knopik & John E. McGeary

  4. Miriam Hospital, Providence, RI, USA

    Michelle A. Lally

  5. Department of Medicine, Alpert Brown Medical School, Providence, RI, USA

    Michelle A. Lally

  6. Department of Veterans Affairs, Providence VA Medical Center, Research Service, 830 Chalkstone Blvd, Providence, RI, 82908, USA

    John E. McGeary

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  1. Nicole R. Nugent
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Correspondence to John E. McGeary.

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Nugent, N.R., Lally, M.A., Brown, L. et al. OPRM1 and Diagnosis-Related Posttraumatic Stress Disorder in Binge-Drinking Patients Living with HIV. AIDS Behav 16, 2171–2180 (2012). https://doi.org/10.1007/s10461-011-0095-8

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