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Imaging diagnosis of autoimmune pancreatitis using endoscopic ultrasonography

  • Special Feature: Review Article
  • Role of ultrasonography in the evaluation of autoimmune pancreatitis
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Abstract

The diagnosis of autoimmune pancreatitis (AIP) is challenging and should be achieved through the comprehensive evaluation of clinical, radiological, serological, and pathological evidence, as there is currently no single reliable diagnostic modality. Endoscopic ultrasonography (EUS) can reveal pancreatic parenchymal and ductal features in much more detail than any other existing imaging modality. In this article, we focused on three applications of EUS, i.e., conventional EUS imaging, EUS elastography (EUS-EG), and contrast-enhanced harmonic EUS (CEH-EUS), for the diagnosis of AIP. Diffuse hypoechoic areas, diffuse enlargement, bile duct wall thickening, and peripancreatic hypoechoic margins on conventional EUS are characteristic features of AIP, and the frequencies of these findings are significantly higher in AIP than in pancreatic cancer (PC). EUS-EG of the pancreatic parenchyma in AIP showed homogenous stiffness and that the elasticity of the pancreas may change after steroid therapy. CEH-EUS revealed focal or diffuse iso-enhancement in most AIP cases and hypo-enhancement in most PC cases. However, some AIP cases show a contrast enhancement pattern similar to that of PC. It should be noted that EUS findings of AIP may differ depending on its stage or disease activity. Differentiation from PC has become an increasingly important issue in the process of diagnosing AIP, and EUS, including elastography and contrast enhancement, could be a promising imaging modality for this purpose.

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Authors and Affiliations

  1. Department of Gastroenterology, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya, 466-8550, Japan

    Takuya Ishikawa, Eizaburo Ohno, Yasuyuki Mizutani & Mitsuhiro Fujishiro

  2. Department of Endoscopy, Nagoya University Hospital, Nagoya, Japan

    Hiroki Kawashima

Authors
  1. Takuya Ishikawa
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  2. Hiroki Kawashima
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  3. Eizaburo Ohno
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  4. Yasuyuki Mizutani
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  5. Mitsuhiro Fujishiro
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Correspondence to Takuya Ishikawa.

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Ishikawa, T., Kawashima, H., Ohno, E. et al. Imaging diagnosis of autoimmune pancreatitis using endoscopic ultrasonography. J Med Ultrasonics 48, 543–553 (2021). https://doi.org/10.1007/s10396-021-01143-w

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  • DOI: https://doi.org/10.1007/s10396-021-01143-w

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