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Changes in the distribution of hepatitis C virus genotypes and their association with shifts in transmission routes in Henan, China

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A Publisher Correction to this article was published on 30 January 2018

This article has been updated

Abstract

Aim

Changes in the prevalence of hepatitis C virus (HCV) genotypes could have considerable impacts on prognosis and therapy of hepatitis C. We aimed to investigate the current distribution of HCV genotypes in Henan province, China, and to assess factors associated with the sort of genotype and evolution of the distribution pattern of HCV genotypes.

Subject and methods

A total of 362 chronic hepatitis C (CHC) patients were enrolled retrospectively in the study. HCV genotypes were determined by DNA sequencing and phylogenetic analysis of the core and/or NS5B regions. Univariate or multivariate analysis was performed for factors associated with HCV genotypes distribution.

Results

Among the 362 samples, the most prevalent genotype was 1b (58.6%), followed by 2a (15.7%), 6a (13.8%), 3a (7.5%), 3b (2.8%), 1a (0.8%), and 2b (0.8%). Multivariate logistic regression models showed that transmission routes and age were independently associated with HCV genotypes. Transfusion of blood or blood product was independently associated with genotype 1b (OR:2.22; 95%CI 1.22–4.04, P = 0.009), while IDU was independently associated with genotype 6a (OR:3.18; 95%CI 1.34–7.51, P = 0.009). Genotype 1b was more frequent in older age patients (OR:1.02; 95%CI 1.00–1.04, P = 0.023), and genotype 6a was more common in younger age individuals (OR:0.97; 95%CI 0.94–0.99, P = 0.029). Changes in HCV genotype distribution were present depending on the year of infection. The prevalence of the HCV genotype 1b decreased over time, while the prevalence of the HCV genotype 6a increased over time.

Conclusions

The most prevalent genotype was still 1b among CHC patients in the Henan province, China. The prevalence of genotype 1b has decreased overtime, and that of genotype 6a has increased in younger patients. The change is attributed to a shift in HCV transmission routes. This study provided further evidence for the prevention and treatment of hepatitis C in future.

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Change history

  • 30 January 2018

    The journal had been advised to revise the title so that Clarivate Analytics can try to count the citations more accurately. There’s been confusion due to the existence of another journal with the same name.

Abbreviations

HCV:

Hepatitis C Virus

CHC:

Chronic hepatitis C

IDU:

Intravenous drug use

AST:

Aspartate aminotransferse

ALT:

Alanine aminotransferse

IQR:

Inter Quartile Range

ANOVA:

Analysis of Variance

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Acknowledgments

We thank the patients for providing serum samples.

Funding

This work was supported by the Science Research Project of the Henan Province (No. 162102310030; No. 162300410294; No. 152102310135; No. 201401015) and the grants from China National Key Clinical Specialty Discipline Construction Program (2013).

Author information

Author notes

  1. Wei Li and Linlin Xi contributed equally to this work.

Authors and Affiliations

  1. Department of Infectious Disease, Zhengzhou University People’s Hospital (Henan Provincial People’s Hospital), Zhengzhou, 450003, China

    Wei Li, Yi Kang & Jia Shang

  2. Department of Clinical Laboratory, Third Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, 450008, China

    Linlin Xi, Qingchun Cai, Ruimin Ding & Chunxia Sun

  3. Department of Infectious Disease, First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China

    Qinglei Zeng

Authors
  1. Wei Li
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  2. Linlin Xi
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  3. Qingchun Cai
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  4. Yi Kang
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  8. Jia Shang
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Corresponding author

Correspondence to Jia Shang.

Ethics declarations

This study was performed in accordance with the ethical standards of the Declaration of Helsinki. Guidelines set by the Institution Review Board of Zhengzhou University People’s Hospital, were strictly followed. Written informed consent was obtained from all patients. All authors have read and approved this version of the article. No conflict of interest exits in the submission of this manuscript.

Conflict of interest

The authors declare that they have no conflict of interest.

Additional information

The original version of this article was revised: Due to the existence of another journal with the same name, the Publisher has added a subtitle, “From Theory to Practice.” Effective as of January 2018, the new title of this Journal is Journal of Public Health: From Theory to Practice.

A correction to this article is available online at https://doi.org/10.1007/s10389-017-0893-1.

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Li, W., Xi, L., Cai, Q. et al. Changes in the distribution of hepatitis C virus genotypes and their association with shifts in transmission routes in Henan, China. J Public Health 26, 157–162 (2018). https://doi.org/10.1007/s10389-017-0845-9

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  • DOI: https://doi.org/10.1007/s10389-017-0845-9

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