Skip to main content
Log in

Identifying time trends in multimorbidity—defining multimorbidity in times of changing diagnostic practices

  • Original Article
  • Published:
Journal of Public Health Aims and scope Submit manuscript

Abstract

Aim

Time trends in multimorbidity have rarely been examined and no criteria have been developed to measure the development of multimorbidity over time. Against the backdrop of increasing numbers of diagnoses a robust measure is needed that is sensitive to changes over time and allows to differentiate between multimorbid and non-multimorbid individuals. We examine how prevalence estimates change as criteria for defining multimorbidity are varied systematically and how this influences the observed time trend.

Subject and methods

Our analyses are based on the data of a German statutory health insurance from 2005 to 2013. Measures are compared using different minimal numbers of chronic conditions required to define multimorbidity: three and six. As a stricter criterion both variants are then combined with polypharmacy.

Results

All definitions of multimorbidity are leading to increasing prevalence rates over time. Defining multimorbidity as the presence of three or more chronic conditions leads to very high prevalence rates and is lacking discriminative power in the oldest old. Lower prevalence rates with a sharp increase over time can be observed in the proportion of insured with at least six chronic conditions. Adding polypharmacy reduces the growth over time remarkably.

Conclusion

The analyses suggest that the increase of multimorbidity is mainly driven by chronic conditions that are not in need of complex medication. Simple disease counts are inappropriate for defining multimorbidity.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

Similar content being viewed by others

References

  • Brandlmeier P (1976) Multimorbidität unter den älteren Patienten in einer städtischen Allgemeinpraxis. ZFA 52:1269–1275

    CAS  Google Scholar 

  • Charlson ME, Pompei P, Ales KL, MacKenzie CR (1987) A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 40(5):373–383

    Article  CAS  PubMed  Google Scholar 

  • Diederichs C, Berger K, Bartels DB (2011) The measurement of multiple chronic diseases—a systematic review on existing multimorbidity indices. J Gerontol A Biol Sci Med Sci 66(3):301–311

    Article  PubMed  Google Scholar 

  • Elixhauser A, Steiner C, Harris DR, Coffey RM (1998) Comorbidity measures for use with administrative data. Med Care 36(1):8–27

    Article  CAS  PubMed  Google Scholar 

  • Feinstein A (1970) The pre-therapeutic classification of co-morbidity in chronic diseases. J Chronic Dis 23:455–468

    Article  CAS  PubMed  Google Scholar 

  • Fortin M, Stewart M, Poitras M, Almirall J, Maddocks H (2012) A systematic review of prevalence studies on multimorbidity: toward a more uniform methodology. Ann Fam Med 10(2):142–151. doi:10.1370/afm.1337

    Article  PubMed  PubMed Central  Google Scholar 

  • Glaeske G, Schicktanz C (2013) BARMER GEK Arzneimittelreport 2013: Auswertungsergebnisse der BARMER GEK Arzneimitteldaten aus den Jahren 2011 bis 2012. Schriftenreihe zur Gesundheitsanalyse, 20. Asgard, Siegburg

  • Grimmsmann T, Himmel W (2009) Polypharmacy in primary care practices: an analysis using a large health insurance database. Pharmacoepidemiol Drug Saf 18(12):1206–1213

    Article  PubMed  Google Scholar 

  • Harrison C, Britt H, Miller G, Henderson J (2014) Examining different measures of multimorbidity, using a large prospective cross-sectional study in Australian general practice. BMJ Open. doi:10.1136/bmjopen-2013-004694

    Google Scholar 

  • Hopman P, Heins MJ, Rijken M, Schellevis FG (2015) Health care utilization of patients with multiple chronic diseases in The Netherlands: differences and underlying factors. Eur J Intern Med 26(3):190–196

    Article  PubMed  Google Scholar 

  • Junius-Walker U, Theile G, Hummers-Pradier E (2007) Prevalence and predictors of polypharmacy among older primary care patients in Germany. Fam Pract 24(1):14–19

    Article  CAS  PubMed  Google Scholar 

  • Koper D, Kamenski G, Flamm M, Böhmdorfer B, Sönnichsen A (2013) Frequency of medication errors in primary care patients with polypharmacy. Fam Pract 30(3):313–319

    Article  PubMed  Google Scholar 

  • Le Reste JY, Nabbe P, Manceau B, Lygidakis C, Doerr C, Lingner H, Czachowski S, Munoz M, Argyriadou S, Claveria A, Le Floch B, Barais M, Bower P, van Marwijk H, van Royen P, Lietard C (2013) The European General Practice Research Network presents a comprehensive definition of multimorbidity in family medicine and long term care, following a systematic review of relevant literature. J Am Med Dir Assoc 14(5):319–325

    Article  PubMed  Google Scholar 

  • Lefèvre T, d’Ivernois J, de Andrade V, Crozet C, Lombrail P, Gagnayre R (2014) What do we mean by multimorbidity? An analysis of the literature on multimorbidity measures, associated factors, and impact on health services organization. Rev Epidemiol Sante Publique 62(5):305–314

    Article  PubMed  Google Scholar 

  • Marengoni A, Angleman S, Melis R, Mangialasche F, Karp A, Garmen A, Meinow B, Fratiglioni L (2011) Aging with multimorbidity: a systematic review of the literature. Ageing Res Rev 10(4):430–439

    Article  PubMed  Google Scholar 

  • Pefoyo AJK, Bronskill SE, Gruneir A, Calzavara A, Thavorn K, Petrosyan Y, Maxwell CJ, Bai Y, Wodchis WP (2015) The increasing burden and complexity of multimorbidity. BMC Public Health. doi:10.1186/s12889-015-1733-2

    PubMed  Google Scholar 

  • Scott IA, Anderson K, Freeman CR, Stowasser DA (2014) First do no harm: a real need to deprescribe in older patients. Med J Aust 201(7):390–392

    Article  PubMed  Google Scholar 

  • StataCorp (2013) Stata statistical software: release 13. StataCorp LP, College Station

    Google Scholar 

  • Statistisches Bundesamt (2015) Sozialleistungen: Angaben zur Krankenversicherung 2011. https://www.destatis.de/DE/Publikationen/Thematisch/Bevoelkerung/HaushalteMikrozensus/KrankenversicherungMikrozensus2130110119004.pdf?__blob=publicationFile. Accessed 21 January 2015

  • Swart E, Gothe H, Geyer S, Jaunzeme J, Maier B, Grobe TG, Ihle P (2015) Good Practice of Secondary Data Analysis (GPS): guidelines and recommendations (Gute Praxis Sekundardatenanalyse (GPS): Leitlinien und Empfehlungen). Gesundheitswesen 77(2):120–126

    Article  CAS  PubMed  Google Scholar 

  • Uijen AA, van de Lisdonk EH (2008) Multimorbidity in primary care: prevalence and trend over the last 20 years. Eur J Gen Pract 14(Suppl 1):28–32

    Article  PubMed  Google Scholar 

  • van den Akker M, Buntinx F, Knottnerus JA (1996) Comorbidity or multimorbidity: what’s in a name? A review of literature. Eur J Gen Pract 2(2):65–70

    Article  Google Scholar 

  • van den Bussche H, Scherer M (2011) Das Verbundvorhaben „Komorbidität und Multimorbidität in der hausärztlichen Versorgung“ (MultiCare) (The joint research project „Comorbidity and multimorbidity in primary care “(MultiCare)). Z Gerontol Geriatr 44(Suppl 2):73–100

    Article  PubMed  Google Scholar 

  • van den Bussche H, Koller D, Kolonko T, Hansen H, Wegscheider K, Glaeske G, von Leitner E, Schäfer I, Schön G (2011) Which chronic diseases and disease combinations are specific to multimorbidity in the elderly? Results of a claims data based cross-sectional study in Germany. BMC Public Health. doi:10.1186/1471-2458-11-101

    PubMed  PubMed Central  Google Scholar 

  • WHO Collaborating Centre for Drug Statistics Methodology (2015) Guidelines for ATC classification and DDD assignment 2015, Oslo

  • Wister AV, Levasseur M, Griffith LE, Fyffe I (2015) Estimating multiple morbidity disease burden among older persons: a convergent construct validity study to discriminate among six chronic illness measures, CCHS 2008/09. BMC Geriatr. doi:10.1186/s12877-015-0001-8

    PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgments

The permission of the Allgemeine Ortskrankenkasse Niedersachsen (AOK Niedersachsen-Statutory Health Insurance of Lower Saxony) to work with the health insurance data is greatly appreciated. In particular, the support of Jürgen Peter (AOK Niedersachsen) made it possible to carry out the project from which the data were derived.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Juliane Tetzlaff.

Ethics declarations

Funding

The work done by JT was funded by the AOK Niedersachsen-Statutory Health Insurance of Lower Saxony as part of a project on morbidity compression.

The work done by DM was funded by the Ministry of Science and Culture of Lower Saxony as part of the doctoral program GESA: Health related care for a self-determined life in old age—Theoretical concepts, users’ needs and responsiveness of the health care system.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors. The AOK Niedersachsen gave permission to use the data.

Conflict of interest

The authors declare that they have no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Tetzlaff, J., Junius-Walker, U., Muschik, D. et al. Identifying time trends in multimorbidity—defining multimorbidity in times of changing diagnostic practices. J Public Health 25, 215–222 (2017). https://doi.org/10.1007/s10389-016-0771-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10389-016-0771-2

Keywords

Navigation