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Preoperative low serum creatine kinase is associated with poor overall survival in the male patients with esophageal squamous cell carcinoma

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Abstract

Background

Serum creatine kinase level has been reported to be a prognostic indicator in breast or lung cancers but no reports have been in esophageal cancer. We analyzed the prognostic significance of preoperative serum creatine kinase level in patients with esophageal carcinoma.

Methods

We evaluated the preoperative serum creatine kinase levels of 148 patients (118 male and 30 female) with esophageal squamous cell carcinoma. According to their median serum creatine kinase levels, we divided the patients into high and low serum creatine kinase groups. Univariate and multivariate analyses were used to evaluate the impact of serum creatine kinase level on the prognosis of the patients.

Results

The tumor depth (P < 0.01) and stage (P < 0.01) were significantly associated with serum creatine kinase levels. The prognosis was worse in the low serum creatine kinase group than in the high serum creatine kinase group (P = 0.02). In the subgroup analysis, although no survival difference was observed in the female patients between the groups (P = 0.171), the survival of low serum creatine kinase group was significantly worse than that of high creatine kinase group in the male patients (P = 0.001). Cox proportional hazard regression analysis revealed that nodal status (P = 0.019) and serum creatine kinase level (P = 0.047) were independent risk factors associated with overall survival in the male patients.

Conclusions

Preoperative low serum creatine kinase level was useful in predicting overall survival in the male patients with esophageal squamous cell carcinoma.

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Acknowledgements

This work was partially supported by a Grant in-aid JSPS KAKENHI (Grant number 16K10520). The authors would like to thank MARUZEN-YUSHODO Co., Ltd (https://kw.maruzen.co.jp/kousei-honyaku/) for the English language editing.

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Authors and Affiliations

  1. Department of Clinical Oncology, Toho University, 6-11-1 Omori-nishi, Ota-ku, Tokyo, 142-8541, Japan

    Kenji Murayama

  2. Department of Gastroenterological Surgery and Clinical Oncology, Graduate School of Medicine, Toho University, 6-11-1 Omori-nishi, Ota-ku, Tokyo, 142-8541, Japan

    Takashi Suzuki, Satoshi Yajima, Yoko Oshima, Tatsuki Nanami, Fumiaki Shiratori & Hideaki Shimada

Authors
  1. Kenji Murayama
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  2. Takashi Suzuki
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  3. Satoshi Yajima
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  4. Yoko Oshima
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  5. Tatsuki Nanami
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  6. Fumiaki Shiratori
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  7. Hideaki Shimada
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Corresponding author

Correspondence to Hideaki Shimada.

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Ethical statement

This retrospective study was approved by the Institutional Ethics Committee of Toho University Omori Medical Center (Tokyo, Japan; #M20196_18056_18002).

Conflict of interest

Hideaki Shimada received research Grants and technical lecture fees from Ono Pharmaceutical Co., Ltd., Taiho Pharmaceutical Co., Ltd. and Chugai Pharmaceutical Co., Ltd. The other authors declare that they have no conflicts of interest.

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Murayama, K., Suzuki, T., Yajima, S. et al. Preoperative low serum creatine kinase is associated with poor overall survival in the male patients with esophageal squamous cell carcinoma. Esophagus 19, 105–112 (2022). https://doi.org/10.1007/s10388-021-00866-6

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  • DOI: https://doi.org/10.1007/s10388-021-00866-6

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