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Acute effect of pseudoephedrine on macular microcirculation in healthy subjects: an optical coherence tomography angiography study

  • Clinical Investigation
  • Published:
Japanese Journal of Ophthalmology Aims and scope Submit manuscript

A Correction to this article was published on 02 November 2021

This article has been updated

Abstract

Purpose

To quantitatively evaluate the acute effects of pseudoephedrine on the macular microvasculature using optical coherence tomography angiography (OCTA).

Study design

Randomized placebo-controlled clinical study.

Methods

In this study, 60 right eyes of 60 healthy subjects were divided into 2 groups. The study group received 60 mg of pseudoephedrine and the control group received a placebo. All participants underwent OCTA at baseline and 1 h after oral intake. Superficial macular flow area, foveal avascular zone (FAZ), superficial macular vessel density, central foveal thickness (CFT) and subfoveal choroidal thickness (SFCT) were analyzed.

Results

Baseline superficial macular flow area, FAZ area, superficial macular vessel density, CFT and SFCT measurements in the study and control groups showed no significant difference (p > 0.05 for all). Oral pseudoephedrine intake caused a significant reduction in superficial macular flow area, FAZ area, superficial macular vessel density and SFCT measurements when compared with baseline (p < 0.05 for all). However, there was no significant difference in CFT after oral pseudoephedrine intake (p > 0.05).

Conclusion

Oral pseudoephedrine intake causes a significant decrease in superficial macular blood flow and SFCT. Impairmant of macular microcirculation can be detected noninvasively and quantitavitely by OCTA.

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Authors and Affiliations

  1. Alfa Medical Center, 6244 St. No:1, Bornova, 35040, Izmir, Turkey

    Ibrahim Tuncer

  2. West Eye Center, Izmir, Turkey

    Ugur Unsal

Authors
  1. Ibrahim Tuncer
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  2. Ugur Unsal
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Correspondence to Ibrahim Tuncer.

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I. Tuncer, None; U. Unsal, None.

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Corresponding Author: Ibrahim Tuncer

The original online version of this article was revised due to update in Figure 2.

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Tuncer, I., Unsal, U. Acute effect of pseudoephedrine on macular microcirculation in healthy subjects: an optical coherence tomography angiography study. Jpn J Ophthalmol 66, 94–100 (2022). https://doi.org/10.1007/s10384-021-00859-z

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  • DOI: https://doi.org/10.1007/s10384-021-00859-z

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