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Recent trends of ocular complications in patients with atopic dermatitis

  • Clinical Investigation
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Japanese Journal of Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To elucidate the recent trends in prevalence and characteristics of ocular complications of atopic dermatitis (AD).

Study Design

Cross-sectional observational study.

Methods

Among AD patients who visited our department between 2012 and 2015, 70 patients (140 eyes; recent AD group) who gave informed consent to participate in the study were analyzed. Following a medical interview, ophthalmological examinations were conducted for ocular complications related to AD. The data were compared to those of 280 AD patients (560 eyes) analyzed in a similar study conducted at our department in 1991–1993 (previous AD group).

Results

Blepharitis was found in 58 eyes (41%) in the recent AD group, and the frequency was significantly lower compared to the previous AD group (294 eyes, 53%) (p < 0.05). Tears in retina or pars plana ciliaris occurred in 22 eyes (4%) in the previous AD group, compared with none in the recent AD group (p < 0.01). Retinal detachment was observed in 12 eyes (2%) in the previous AD group, and none in the recent AD group (p < 0.01). Atopic keratoconjunctivitis (AKC) increased significantly in the recent AD group compared to the previous AD group (74.3% vs. 39.5%) (p < 0.001). Patients with a habit of slapping around the eye decreased significantly from 32.5% in the previous AD group to 12.1% in the recent AD group (p < 0.001).

Conclusions

Ocular complications in AD patients show a trend of decrease in recent years, which presumably is attributed to educational activities to increase patient awareness and advances in therapeutic strategy.

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References

  1. Katayama I, Aihara M, Ohya Y, Saeki H, Shimojo N, Shoji S, et al. The Japanese Society of Allergology. Japanese guidelines for atopic dermatitis 2017. Allergol Int. 2017;66:230–47.

    Article  PubMed  Google Scholar 

  2. Saeki H. Management of atopic dermatitis in Japan. J Nippon Med Sch. 2017;84:2–11.

    Article  PubMed  Google Scholar 

  3. Saeki H, Furue H, Furukawa F, Hide M, Ohtsuki M, Katayama I, et al. Committee for guidelines for the management of atopic dermatitis of Japanese Dermatological Association. Guidelines for management of atopic dermatitis. J Dermatol. 2009;36:563–77.

    Article  PubMed  Google Scholar 

  4. Rich LF, Hanifin JM. Ocular complication of atopic dermatitis and other eczemas. Int Ophthalmol Clin. 1985;25:61–76.

    Article  CAS  PubMed  Google Scholar 

  5. Hoshino M, Sekine Y, Takahashi H, Iwata M, Honmura S, Otsuka F. Atopic dermatitis and its ocular complications. Jpn J Dermatol. 1984;104:1361–6 (in Japanese).

    Google Scholar 

  6. Goto H, Sanada A, Wakabayashi Y, Yagihashi T, Iwasaki T, Usui M, et al. The role of trauma in the pathogenesis of atopic cataract. Atarashii Ganka (J Eye). 1996;13:1728–32 (in Japanese).

    Google Scholar 

  7. Goto H, Yagihashi T, Miyake M, Kusano T, Sanada A, Yamakawa N, et al. Blunt trauma-induced experimental cataract model: the role of trauma in the pathogenesis of atopic cataracts. Atarashii Ganka (J Eye). 1996;13:1733–8 (in Japanese).

    Google Scholar 

  8. Nakano E, Iwasaki T, Osanai T, Yamamoto K, Miyauchi M. Ocular complications of atopic dermatitis. Nippon Ganka Gakkai Zasshi (J Jpn Ophthalmol Soc). 1997;101:64–8 (in Japanese).

    CAS  Google Scholar 

  9. Wollenberg A, Ehmann LM. Long term treatment concept and proactive therapy for atopic eczema. Ann Dermatol. 2014;24:253–60.

    Article  CAS  Google Scholar 

  10. Hanifin JM, Thurston M, Omoto M, Cherill R, Tofte SJ, Graeber M. EASI Evaluator Group. The eczema area and severity index (EASI): assessment of reliability in atopic dermatitis. Exp Dermatol. 2001;10:11–8.

    Article  CAS  PubMed  Google Scholar 

  11. Takamura E, Uchio E, Ohya Y, Ebihara N, Ohno S, Ohashi Y, et al. The Japanese Society of Allergology. Japanese guidelines for allergic conjunctival diseases 2017. Allergol Int. 2017;66:220–9.

    Article  PubMed  Google Scholar 

  12. Sasoh M, Mizutani H, Matsubara H, Furuta M, Matsui Y, Yamanaka KV, et al. Incidence of retinal detachment associated with atopic dermatitis in Japan: review of cases from 1992 to 2011. Clin Ophthalmol. 2015;9:1129–34.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Kawakami S, Goto H, Yagihashi T, Iwasaki T, Usui M. Implication of blunt injury in advanced atopic cataract. Rinsho Ganka (Jpn J Clin Ophthamol). 1999;3:701–4 (in Japanese).

    Google Scholar 

  14. Thyssen JP, Toft PB, Halling-Overgaard AS, Gislason GH, Skov L, Egeberg A. Incidence, prevalence, and risk of selected ocular disease in adults with atopic dermatitis. J Am Acad Dermatol. 2017;77:280–6.

    Article  PubMed  Google Scholar 

  15. Okuda M. Epidemiology of Japanese cedar pollinosis throughout Japan. Ann Allergy Asthms Immunol. 2003;91:288–96.

    Article  Google Scholar 

  16. Hanifin J, Gupta AK, Rajagopalan R. Intermittent dosing of fluticasone propionate cream for reducing the risk of relapse in atopic dermatitis patients. Br J Dermatol. 2002;147:528–37.

    Article  CAS  PubMed  Google Scholar 

  17. Berth-Jones J, Damstra RJ, Golsch S, Livden JK, Van Hooteghem O, Allegrra F, et al. Multinational Study Group. Twice weekly fluticasone propionate added to emollient maintenance treatment to reduce risk of relapse in atopic dermatitis: randomized, double blind, parallel group study. BMJ. 2003;326:1367–70.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Peserico A, Stadtlere G, Sebastian M, Fernandez RS, Vick K, Bieber T. Reduction of relapse of atopic dermatitis with methylprednisolone aceponate cream twice weekly in addition to maintenance treatment with emollient: a multicenter, randomized, double-blind, controlled study. Br J Dermatol. 2008;158:801–7.

    Article  CAS  PubMed  Google Scholar 

  19. Glazenbulg EJ, Wolkerstorfer A, Gerretsen AL, Mulder PGH, Oranje AP. Efficacy and safety of fluticasone propionate 0.005% ointment in the long-term maintenance treatment of children with atopic dermatitis: differences between boys and girls? Pedriatr Allergy Immunol. 2009;20:59–66.

    Article  Google Scholar 

  20. Wollenberg A, Reitamo S, Girolomoni G, Lahfa M, Ruzicka T, Healy E, et al. European Tacrolimus Ointment Study Group. Proactive treatment of atopic dermatitis in adults with 0.1% tacrolimus ointment. Allergy. 2008;63:742–50.

    Article  CAS  PubMed  Google Scholar 

  21. Breneman D, Fleischer AB, Abramovits W, Zeichner J, Gold MH, Kirsner RS, et al. Tacrolimus Ointment Study Group. Intermittent therapy for flare prevention and long-term disease control in stabilized atopic dermatitis: a randomized comparison of 3-times-weekly applications of tacrolimus ointment versus vehicle. J Am Acad Dermatol. 2008;68:990–9.

    Article  Google Scholar 

  22. Wollenberg A, Sidhu MK, Odeyemi I, Porsh B, Koehne-Volland R, Schaffe M, et al. Economic evaluation of maintenance treatment with tacrolimus 0.1% ointment in adults with moderate to severe atopic dermatitis. Br J Dermatol. 2008;159:1322–30.

    Article  CAS  PubMed  Google Scholar 

  23. Thaci D, Reitamo S, Gonzalez Ensenat MA, Moss C, Boccaletti V, Cainelli T, et al. European Tacrolimus Ointment Study Group. Proactive disease management with 0.03% tacrolimus ointment for children with atopic dermatitis: results of a randomized, multicenter, comparative study. Br J Dermatol. 2008;159:1348–56.

    Article  CAS  PubMed  Google Scholar 

  24. Chung BY, Kim HO, Kim JH, Chos I, Lee CH, Park CW. The proactive treatment of atopic dermatitis with tacrolimus ointment in Korean patients: a comparative study between once-weekly and thrice-weekly applications. Br J Dermatol. 2013;168:908–10.

    Article  CAS  PubMed  Google Scholar 

  25. Schmitt J, von Kobbylezki L, Svensson A, Apfelbacher C. Efficacy and tolerability of proactive treatment with topical corticosteroids and calcineurin inhibitors for atopic eczema: systematic review and metaanalysis of randomized controlled trials. Br J Dermatol. 2011;164:415–28.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Ophthalmology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan

    Kaori Yamamoto, Yoshihiro Wakabayashi, Setsuko Kawakami & Hiroshi Goto

  2. Department of Dermatology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan

    Takafumi Numata, Tomonobu Ito, Yukari Okubo & Ryoji Tsuboi

Authors
  1. Kaori Yamamoto
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  2. Yoshihiro Wakabayashi
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  3. Setsuko Kawakami
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  4. Takafumi Numata
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  5. Tomonobu Ito
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  6. Yukari Okubo
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  8. Hiroshi Goto
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Corresponding author

Correspondence to Kaori Yamamoto.

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Conflicts of interest

K. Yamamoto, None; Y. Wakabayashi, None; S. Kawakami, None; T. Numata, None; T. Ito, None; Y. Okubo, None; R. Tsuboi, None; H. Goto, None.

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Corresponding author: Kaori Yamamoto

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Yamamoto, K., Wakabayashi, Y., Kawakami, S. et al. Recent trends of ocular complications in patients with atopic dermatitis. Jpn J Ophthalmol 63, 410–416 (2019). https://doi.org/10.1007/s10384-019-00678-3

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  • DOI: https://doi.org/10.1007/s10384-019-00678-3

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