Skip to main content

Advertisement

SpringerLink
Log in

Utility values in Japanese patients with exudative age-related macular degeneration

  • Clinical Investigation
  • Published:
Japanese Journal of Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To investigate the utility values associated with visual loss due to age-related macular degeneration (AMD) in Japanese patients.

Methods

Utility values in 48 Japanese patients with bilateral exudative AMD were measured using the time trade-off and standard gamble methods.

Results

The time trade-off method utility values correlated with the best-corrected visual acuity (BCVA) in the better-seeing eye. The estimated utility values according to the BCVA in the better-seeing eye were 0.534 (BCVA, 0.01–0.15), 0.574 (0.2–0.3), 0.613 (0.4–0.6), and 0.653 (0.7–1.0). The utility values obtained by the standard gamble method were not significantly correlated with BCVA in the betterseeing eye.

Conclusions

The present results concur with those of previous studies showing that AMD causes a substantial decrease in patient utility values. The utility values obtained in the current study provide important information for use in cost-utility analysis of interventions for Japanese AMD patients.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Kawasaki R, Wang JJ, Ji GJ, et al. Prevalence and risk factors for age-related macular degeneration in an adult Japanese population: the Funagata study. Ophthalmology 2008;115:1376–1381.

    Article  PubMed  Google Scholar 

  2. Brown GC, Brown MM, Brown HC, Kindermann S, Sharma S. A value-based medicine comparison of interventions for subfoveal neovascular macular degeneration. Ophthalmology 2007;114:1170–1178.

    Article  PubMed  Google Scholar 

  3. Brown GC, Sharma S, Brown MM, Kistler J. Utility values and age-related macular degeneration. Arch Ophthalmol 2000;118:47–51.

    CAS  PubMed  Google Scholar 

  4. Sharma S, Brown GC, Brown MM, Hollands H, Shah GK. The cost-effectiveness of photodynamic therapy for fellow eyes with subfoveal choroidal neovascularization secondary to age-related macular degeneration. Ophthalmology 2001;108:2051–2059.

    Article  CAS  PubMed  Google Scholar 

  5. Brown MM, Brown GC, Brown HC, Peet J. A value-based medicine analysis of ranibizumab for the treatment of subfoveal neovascular macular degeneration. Ophthalmology 2008;108:1039–1045.

    Article  Google Scholar 

  6. Karnon J, Czoski-Murray C, Smith K, et al. A preliminary modelbased assessment of the cost-utility of a screening programme for early age-related macular degeneration. Health Technol Assess 2008;12:iii–iv, ix–124.

    CAS  Google Scholar 

  7. Meads C, Salas C, Roberts T, Moore D, Fry-Smith A, Hyde C. Clinical effectiveness and cost-utility of photodynamic therapy for wet age-related macular degeneration: a systematic review and economic evaluation. Health Technol Assess 2003;9:v–vi, 1–98.

    Google Scholar 

  8. Hopley C, Salkeld G, Mitchell P. Cost utility of photodynamic therapy for predominantly classic neovascular age-related macular degeneration. Br J Ophthalmol 2004;88:982–987.

    Article  CAS  PubMed  Google Scholar 

  9. Suzukamo Y, Oshika T, Yuzawa M, et al. Psychometric properties of the 25-item National Eye Institute Visual Function Questionnaire (NEI VFQ-25), Japanese version. Health Qual Life Outcomes 2005;3:65.

    Article  PubMed  Google Scholar 

  10. Ueta T, Obata R, Inoue Y, et al. Background comparison of typical age-related macular degeneration and polypoidal choroidal vasculopathy in Japanese patients. Ophthalmology 2009;116:2400–2406.

    Article  PubMed  Google Scholar 

  11. Saito K, Yamamoto T, Tsuchiya D, Kawasaki R, Haneda S, Yamashita H. Effect of combined treatment with sub-Tenon injection of triamcinolone acetonide and photodynamic therapy in Japanese patients with age-related macular degeneration. Jpn J Ophthalmol 2009;53:512–518.

    Article  CAS  PubMed  Google Scholar 

  12. Bansback N, Davis S, Brazier J. Using contrast sensitivity to estimate the cost-effectiveness of verteporfin in patients with predominantly classic age-related macular degeneration. Eye 2007;21:1455–1463.

    Article  CAS  PubMed  Google Scholar 

  13. Espallargues M, Czoski-Murray CJ, Bansback NJ, et al. The impact of age-related macular degeneration on health status utility values. Invest Ophthalmol Vis Sci 2005;46:4016–4023.

    Article  PubMed  Google Scholar 

  14. Maruko I, Iida T, Saito M, Nagayama D, Saito K. Clinical characteristics of exudative age-related macular degeneration in Japanese patients. Am J Ophthalmol 2007;144:15–22.

    Article  PubMed  Google Scholar 

  15. Ueta T, Iriyama A, Francis J, et al. Development of typical agerelated macular degeneration and polypoidal choroidal vasculopathy in fellow eyes of Japanese patients with exudative age-related macular degeneration. Am J Ophthalmol 2008;146:96–101.

    Article  PubMed  Google Scholar 

  16. Kymes SM, Lee BS. Preference-based quality of life measures in people with visual impairment. Optom Vis Sci 2007;84:809–816.

    Article  PubMed  Google Scholar 

  17. Brown GC, Brown MM, Brown HC, Kindermann S, Sharma S. The goal of value-based medicine analyses: comparability. The case for neovascular macular degeneration. Trans Am Ophthalmol Soc 2007;105:160–169.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, Japan

    Yasuo Yanagi, Takashi Ueta, Ryo Obata & Aya Iriyama

  2. Department of Health Economics and Epidemiology Research, University of Tokyo School of Public Health, Tokyo, Japan

    Takashi Fukuda & Hideki Hashimoto

  3. Department of Ophthalmology, University of Tokyo School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan

    Yasuo Yanagi

Authors
  1. Yasuo Yanagi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Takashi Ueta
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ryo Obata
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Aya Iriyama
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Takashi Fukuda
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Hideki Hashimoto
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yasuo Yanagi.

About this article

Cite this article

Yanagi, Y., Ueta, T., Obata, R. et al. Utility values in Japanese patients with exudative age-related macular degeneration. Jpn J Ophthalmol 55, 35–38 (2011). https://doi.org/10.1007/s10384-010-0893-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10384-010-0893-y

Keywords

Search

Navigation