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RETRACTED ARTICLE: Angiopoietin4 (ANGPT4) expression and potential mechanisms in carcinogenesis: current achievements and perspectives

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This article was retracted on 06 April 2024

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Abstract

Angiopoietin4(ANGPT4) which plays a significant role in endothelial cell proliferation, survival, angiogenesis and expansion in tumors and other pathological states is a significant regulator of tumor angiogenesis. ANGPT4 expression is enhanced in many cancer cells. For example, the overexpression of ANGPT4 promotes the formation, development and progress of lung adenocarcinoma, glioblastoma and ovarian cancer. Related studies show that ANGPT4 encourages the proliferation, survival and invasion of tumor cells, while promoting the expansion of the tumor vascular system and affecting the tumor immune microenvironment. ANGPT4 can also promote carcinogenesis by affecting the ERK1/2, PI3K/AKT and other signal pathways downstream of tyrosine kinase with immunoglobulin-like and EGF-like domains 2(TIE2) and TIE2. Therefore, ANGPT4 may be a potential and significant biomarker for predicting malignant tumor progression and adverse outcomes. In addition, inhibition of ANGPT4 may be a meaningful cancer treatment. This paper reviews the latest research results of ANGPT4 in preclinical research, and emphasizes its role in carcinogenesis. Additional research on the carcinogenic function of ANGPT4 could provide new insights into cancer biology and novel methods for cancer diagnosis and treatment.

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Funding

The present study was supported by the Natural Science Foundation of HuNan Province (2021JJ50070 and 2023JJ41066) and the Key Project of Scientific Research Project of HuNan Provincial Education Department (22A0317).

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Author notes

  1. Wen-chao Zhou, Qun-feng Zhang and Jun-ling Chen have contributed equally to this work.

Authors and Affiliations

  1. Department of Gynecology, Hunan Province Key Laboratory of Tumor Cellular and Molecular Pathology, Hengyang Medical School, Cancer Research Institute, The Second Affiliated Hospital, University of South China, Hengyang, Hunan, China

    Wen-chao Zhou, Qun-feng Zhang, Jun-ling Chen, Jin-peng Gan & Juan Zou

  2. Department of Assisted Reproductive Centre, Zhuzhou Central Hospital, Xiangya Hospital Zhuzhou Central South University, Central South University, Zhuzhou, Hunan, China

    Yu-kun Li & Juan Zou

Authors
  1. Wen-chao Zhou
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  4. Jin-peng Gan
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Contributions

All authors contributed to the study conception and design. WCZ, JLC and QFZ designed the project. WCZ, JLC and JPG wrote the paper. YKL drawing the graph. YKL and JZ revised the manuscript, designed the experiment.

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Correspondence to Yu-kun Li or Juan Zou.

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This article has been retracted. Please see the retraction notice for more detail: https://doi.org/10.1007/s10238-024-01338-8

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Zhou, Wc., Zhang, Qf., Chen, Jl. et al. RETRACTED ARTICLE: Angiopoietin4 (ANGPT4) expression and potential mechanisms in carcinogenesis: current achievements and perspectives. Clin Exp Med 23, 4449–4456 (2023). https://doi.org/10.1007/s10238-023-01178-y

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