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Factors affecting inadequate response to HBV vaccine in hemodialysis patients: northeast anatolia survey with six hemodialysis centers

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Abstract

Background

In hemodialysis patients Hepatitis B virus (HBV) infection is one of the problems. Because of HBV vaccine response is lower than in the general population, in this study it is aimed to determine the factors that may cause inadequate HBV vaccine response in hemodialysis patients.

Methods

In study, HBsAg, anti-HBs, anti-HBc IgG data belonging to 278 patients were obtained from file and computer records. It was seen that seronegative cases had been given recombinant HBV vaccine. Anti-HBs titers were monitored 1 month after vaccination was completed. According to this, the patients are divided into two groups. Those with anti-HBs < 10 IU/mL were identified as non-responders and with anti-HBs ≥ 10 IU/mL as responders. Factors such as age, serum albumin and urea reduction rate which may affect inadequate response to HBV vaccine were evaluated. As statistical examination, Chi-square test was used for the analysis of the data determined by counting, and logistic regression was used for statistically significant independent variables in chi-square test. p value of < 0.05 was considered statistically significant (Confidence interval: 95%).

Results

Out of 278 patients, according to exclusion criteria 81 patients were excluded. 13.2%(26/197) of HBV vaccinated patients had insufficient response. The inadequate response rate to HBV vaccination was found to be higher in patients with age ≥ 65 (p = 0.039), serum albumin < 3.5 g/dL (p = 0.024) and urea reduction rate ≤ 65 (p = 0.028). No statistically significant relationship was found between inadequate response to HBV vaccine and anti-HCV positivity, presence of diabetes mellitus, anemia status, vitamin D therapy and vascular access pathway variability.

Conclusion

We conclude that relatively high patient age, low albumin level and insufficient urea reduction rate may cause inadequate HBV vaccine response. Taking these factors into consideration may provide a useful insight for an adequate response to vaccination.

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Acknowledgements

We would also thank to Associate Professor Dr. Binali Catak, from the Department of Public Health for his contribution.

Author information

Authors and Affiliations

  1. Department of Internal Medicine, Health Research Center, Kafkas University, Kars, Turkey

    Halil İbrahim Erdoğdu, Eray Atalay & Merve Erat

  2. Department of Internal Medicine and Endocrinology, Kafkas University, Kars, Turkey

    Gül Gürsoy

  3. Department of Internal Medicine and Neprology, Kafkas University, Kars, Turkey

    Başol Canbakan

  4. Department of Hemodialysis and Nephrology, Kars Harakani State Hospital, Kars, Turkey

    Serkan Aktürk & Orhan Yücel

  5. Departement of Internal Medicine, Ardahan State Hospital, Ardahan, Turkey

    Canan Yazıcı

  6. Department of Internal Medicine, Kartal Lütfi Kırdar Education and Research Hospital, Istanbul, Turkey

    Sinan Mersin

  7. Department of Clinical Microbiology and Infectious diseases, Kafkas University, Kars, Turkey

    Sengül Üçer

  8. Department of Hemodialysis and Nephrology, Iğdır State Hospital, Iğdır, Turkey

    Özgür Merhametsiz

  9. Department of Family Medicine, Kartal Lütfi Kırdar Education and Research Hospital, Istanbul, Turkey

    Can Öner

Authors
  1. Halil İbrahim Erdoğdu
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  2. Eray Atalay
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  7. Orhan Yücel
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  8. Sinan Mersin
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  9. Sengül Üçer
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  10. Özgür Merhametsiz
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  11. Can Öner
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  12. Merve Erat
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Corresponding author

Correspondence to Halil İbrahim Erdoğdu.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

The study protocol was approved by the Ethics Committee for Clinical Research, Faculty of Medicine, Kafkas University, Kars, Turkey. Our study was conducted according to the declaration of Helsinki. Informed consent was obtained from all individual participants included in the study.

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Erdoğdu, H.İ., Atalay, E., Gürsoy, G. et al. Factors affecting inadequate response to HBV vaccine in hemodialysis patients: northeast anatolia survey with six hemodialysis centers. Clin Exp Nephrol 23, 530–536 (2019). https://doi.org/10.1007/s10157-018-1676-x

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  • DOI: https://doi.org/10.1007/s10157-018-1676-x

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