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Relationship between dietary intake and microalbuminuria: findings from the Takahata study

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Abstract

Background

Although several studies have investigated the relationship between dietary nutrient intake and microalbuminuria, no study of an Asian population has been reported. The present study investigates the relationship between dietary intake and microalbuminuria in a general Japanese population.

Methods

We analyzed 675 men and 924 women who did not have diabetes. Participants who had a urinary albumin-to-creatinine ratio (UACR) ≥300 mg/g, who did not complete a questionnaire regarding food frequency and who did not provide complete urine measurements were excluded. Nutrient intake was assessed by validated food frequency questionnaire. Microalbuminuria was defined as UACR ≥30 mg/g. The relationship between dietary nutrient intake and microalbuminuria was examined using a multiple logistic regression model adjusted for age, total energy intake, body mass index, smoking status, systolic blood pressure and use of antihypertensive medication.

Results

No significant association was observed among the men. The multiple adjusted odds ratios (95% confidence interval) of having microalbuminuria per 1 standard deviation increase in total protein (%kcal), animal protein (%kcal), animal protein (g/day), animal fat, niacin, carbohydrate and β-cryptoxanthin among the women were 1.33 (1.07–1.66), 1.35 (1.09–1.66), 1.42 (1.08–1.88), 1.29 (1.05–1.59), 1.28 (1.04–1.57), 0.73 (0.58–0.92) and 0.76 (0.59–0.996), respectively. The multiple adjusted odds ratio (95% confidence interval) of having microalbuminuria in the highest quintile of n–3 polyunsaturated fatty acids compared with the lowest was 2.16 (1.03–4.54).

Conclusion

Less animal protein and more β-cryptoxanthin in the diet might help to prevent microalbuminuria. Prospective studies including controlled trials are required to confirm this conclusion.

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Acknowledgments

This study was supported by a grant-in-aid from the 21st Century Center of Excellence (COE) and the Global COE Program of the Japan Society for the Promotion of Science. This study was also supported by a Grant-in-Aid for Young Scientists (A) (21689018) from the Ministry of Education, Culture, Sports, Science and Technology, Japan.

Conflict of interest

There are no potential conflicts of interest.

Author information

Authors and Affiliations

  1. Department of Public Health, Yamagata University Graduate School of Medicine, Yamagata, Japan

    Masahiro Sato, Atsushi Hozawa, Li Shao, Katsumi Otani & Akira Fukao

  2. Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, 2-2-2 Iida nishi, Yamagata, 990-9585, Japan

    Tsuneo Konta & Isao Kubota

  3. Global COE Program for Medical Sciences, Japan Society for Promotion of Science, Tokyo, Japan

    Tsuneo Konta, Takeo Kato, Isao Kubota, Hidetoshi Yamashita, Takamasa Kayama & Akira Fukao

  4. Advanced Molecular Epidemiology Research Institute, Faculty of Medicine, Yamagata University, Yamagata, Japan

    Hiroto Narimatsu

  5. Department of Social and Preventive Epidemiology, School of Public Health, The University of Tokyo, Bunkyo, Tokyo, Japan

    Satoshi Sasaki

  6. Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetes, Yamagata University School of Medicine, Yamagata, Japan

    Takeo Kato

  7. Department of Ophthalmology, Yamagata University School of Medicine, Yamagata, Japan

    Hidetoshi Yamashita

  8. Department of Neurosurgery, Yamagata University School of Medicine, Yamagata, Japan

    Takamasa Kayama

Authors
  1. Masahiro Sato
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  2. Atsushi Hozawa
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  3. Tsuneo Konta
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  4. Li Shao
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  5. Katsumi Otani
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  6. Hiroto Narimatsu
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  7. Satoshi Sasaki
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  8. Takeo Kato
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  9. Isao Kubota
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  10. Hidetoshi Yamashita
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  11. Takamasa Kayama
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  12. Akira Fukao
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Corresponding author

Correspondence to Atsushi Hozawa.

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Sato, M., Hozawa, A., Konta, T. et al. Relationship between dietary intake and microalbuminuria: findings from the Takahata study. Clin Exp Nephrol 16, 147–155 (2012). https://doi.org/10.1007/s10157-011-0539-5

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  • DOI: https://doi.org/10.1007/s10157-011-0539-5

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