Abstract
Background
There is evidence from cohort studies for an inverse association between atopic dermatitis and asthma and cutaneous melanoma. However, these studies have been too heterogeneous and did not show statistically significant results. Also, this association has not been compared to traditional melanoma risk factors.
Objectives
To test for associations between history of atopic disorders and melanoma life-time prevalence, and for associations between atopic disorders and melanoma prognosis.
Methods
Validated questionnaires from the European Community Respiratory Health Survey and International Study of Asthma and Allergies in Children protocol on life-time prevalence of atopic disorders were sent to 280 patients with histopathologically confirmed melanoma. The control group consisted of their spouses. The skin phototype was also assessed using a validated questionnaire.
Results
One hundred and eighty-four melanoma patients and 169 controls responded to the questionnaire. The life-time prevalence of atopic dermatitis and hayfever was not different in melanoma patients (8.7 % vs. 8.2, p = 0.890 and 15.2 vs. 18.3 %, p = 0.432, respectively). Asthma was non-significantly lower in melanoma patients (3.8 vs. 8.2 %, p = 0.075). Atopic melanoma patients did not differ from non-atopic patients in terms of Breslow thickness, metastases and second melanomas.
Conclusion
Atopic dermatitis is not a protective factor in cutaneous melanoma but a history of asthma may be.
Similar content being viewed by others
References
Forsea AM, Del Marmol V, de Vries E et al (2013) Melanoma incidence and mortality in Europe new estimates persistent disparities. Br J Dermatol 165:1124–1130
Ward EM et al (2006) Interpreting cancer trends. Ann N Y Acad Sci 1076:29–53
Moan J, Porojnicu AC, Dahlback A (2008) Ultraviolet radiation and malignant melanoma. Adv Exp Med Biol 624:104–116
Dennis LK et al (2008) Sunburns and risk of cutaneous melanoma: does age matter? A comprehensive meta-analysis. Ann Epidemiol 18(8):614–627
Diepgen TL, Mahler V (2002) The epidemiology of skin cancer. Br J Dermatol 146(Suppl 61):1–6
El-Zein M et al (2010) History of asthma or eczema and cancer risk among men: a population-based case-control study in Montreal, Quebec, Canada. Ann Allergy Asthma Immunol 104(5):378–384
Merrill RM, Isakson RT, Beck RE (2007) The association between allergies and cancer: what is currently known? Ann Allergy Asthma Immunol 99(2):102–116 Quiz 117-9, 150
Synnerstad I et al (2008) Low risk of melanoma in patients with atopic dermatitis. J Eur Acad Dermatol Venereol 22(12):1423–1428
Jensen AO et al (2012) Atopic dermatitis and risk of skin cancer: a Danish nationwide cohort study (1977–2006). Am J Clin Dermatol 13(1):29–36
Kallas M et al (2006) Frequency and distribution pattern of melanocytic naevi in Estonian children and the influence of atopic dermatitis. J Eur Acad Dermatol Venereol 20(2):143–148
Broberg A, Augustsson A (2000) Atopic dermatitis and melanocytic naevi. Br J Dermatol 142(2):306–309
Synnerstad I et al (2004) Fewer melanocytic nevi found in children with active atopic dermatitis than in children without dermatitis. Arch Dermatol 140(12):1471–1475
Talbot-Smith A et al (2003) Allergy, atopy, and cancer: a prospective study of the 1981 Busselton cohort. Am J Epidemiol 157(7):606–612
Kolmel KF, Compagnone D (1988) Melanoma and atopy. Dtsch Med Wochenschr 113(5):169–171
Ji J et al (2009) Cancer risk in hospitalised asthma patients. Br J Cancer 100(5):829–833
Kallen B, Gunnarskog J, Conradson TB (1993) Cancer risk in asthmatic subjects selected from hospital discharge registry. Eur Respir J 6(5):694–697
Asher MI et al (1995) International Study of Asthma and Allergies in Childhood (ISAAC): rationale and methods. Eur Respir J 8(3):483–491
Burney PG et al (1994) The European community respiratory health survey. Eur Respir J 7(5):954–960
Fitzpatrick TB (1988) The validity and practicality of sun-reactive skin types I through VI. Arch Dermatol 124(6):869–871
Hajdarbegovic E et al (2013) Decreased prevalence of atopic features in patients with psoriatic arthritis, but not in psoriasis vulgaris. J Am Acad Dermatol 68:270–277
Conflict of interest
The authors declare that they have no conflict of interest.
Author information
Authors and Affiliations
Corresponding author
About this article
Cite this article
Hajdarbegovic, E., Atiq, N., van der Leest, R. et al. Atopic dermatitis is not a protective factor for melanoma but asthma may be. Int J Clin Oncol 19, 708–711 (2014). https://doi.org/10.1007/s10147-013-0589-7
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10147-013-0589-7