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Selective laser trabeculoplasty lowered the untreated fellow eye long-term intraocular pressure: a 3-year observational study

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Abstract

To explore the long-term intraocular pressure (IOP)-lowering effect of monocular selective laser trabeculoplasty (SLT) in the untreated fellow eyes of open-angle glaucoma (OAG) patients. This was a retrospective observational study. Consecutive Chinese OAG patients who received monocular SLT treatment were included in this study. One hundred and eighty degree SLT was conducted as adjunctive treatment when anti-glaucoma medication was not sufficiently effective after clinical evaluation. Treatment success was defined as more than 20% IOP reduction of the baseline IOP levels. IOP-decreasing amplitude and SLT success rate of both eyes were investigated during the 3-year follow-up period. Age, gender, baseline IOP levels, number of medications, and SLT energy parameters were analyzed to determine its influence on IOP reduction effect and treatment success rate. A total of 32 Chinese OAG patients were included in this study and 25 of them completed the 3-year follow-ups. Their pretreatment IOPs were 18.85 ± 2.81 mmHg in the treated eyes and 17.38 ± 2.37 mmHg in the fellow eyes. At the 3-year follow-up visits, IOP decreased to 2.76 ± 3.72 mmHg (14.16%) in the treated eyes and 2.16 ± 2.73 mmHg (11.95%) in the fellow eyes, with a success rate of 47.83% (11 in 23 cases) and 44.00% (11 in 25 cases), respectively. IOPs of both eyes decreased significantly after SLT from 6 months and lasted to 3 years after treatment. Baseline IOP level was positively correlated with IOP reduction in the treated eyes and other factors were not correlated with IOP reduction and treatment success. Monocular SLT treatment as adjunctive treatment could lower IOPs not only in the treated eyes but also in the untreated eyes in poor medication-controlled OAG patients. In addition, its IOP reduction effect could last to 3 years after treatment in clinical practice.

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Authors and Affiliations

  1. Department of Ophthalmology, Peking University Third Hospital, Beijing, People’s Republic of China

    Yan Liu, Xiang Fan & Lingling Wu

  2. Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Third Hospital, 49 North Garden Road, Haidian District, Beijing, 100191, People’s Republic of China

    Yan Liu, Xiang Fan & Lingling Wu

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  1. Yan Liu
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  2. Xiang Fan
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Contributions

Yan Liu finished the clinical observations, wrote the paper, and edited the manuscript.

Xiang Fan finished the clinical observations, reviewed, and edited the manuscript.

Lingling Wu conceived and designed the study, finished the follow-ups, and reviewed the manuscript.

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Correspondence to Lingling Wu.

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The study followed the tenets of the Declaration of Helsinki and was approved by the institutional review board of Peking University Third Hospital.

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Liu, Y., Fan, X. & Wu, L. Selective laser trabeculoplasty lowered the untreated fellow eye long-term intraocular pressure: a 3-year observational study. Lasers Med Sci 37, 1487–1493 (2022). https://doi.org/10.1007/s10103-021-03253-w

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  • DOI: https://doi.org/10.1007/s10103-021-03253-w

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