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Effect of soft laser and bioactive glass on bone regeneration in the treatment of bone defects (an experimental study)

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Abstract

This study aimed to investigate the influence of low-power gallium–aluminium–arsenide (GaAlAs) laser [830 nm, continuous wave (CW), 40 mW and fluence 4 J/cm2] on the healing of surgically created bone defects in rats treated with bioactive glass graft material. Surgical bone defects were created in the mandibles of 36 Wistar rats divided into two groups, each consisting of 18 rats. Group I was treated with bioactive glass plus laser irradiation. Group II was treated with graft material only. The animals were killed at 4 weeks, 8 weeks and 12 weeks postoperatively for histological examination. Laser irradiation had significantly accelerated bone healing at 4 weeks and 8 weeks in comparison with that at the sites not irradiated. However at 12 weeks, complete healing of the defects had occurred with no difference detected. Our results have confirmed the positive effect of soft laser in accelerating bone regeneration.

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References

  1. Sculean A, Barbe G, Chiantella GC, Arweiler NB, Berakdar M, Brecx M (2002) Clinical evaluation of an enamel matrix protein derivative combined with a bioactive glass for the treatment of intrabony periodontal defects in humans. J Periodontol 73:401–408. doi:10.1902/jop.2002.73.4.401

    Article  PubMed  CAS  Google Scholar 

  2. Dybvik T, Leknes KN, Boe OE, Skavland RJ, Albandar JM (2007) Bioactive ceramic filler in the treatment of severe osseous defects: 12-month results. J Periodontol 78:403–410. doi:10.1902/jop.2007.060263

    Article  PubMed  CAS  Google Scholar 

  3. Pinheiro AL, Gerbi ME (2006) Photo engineering of bone repair processes. Photomed Laser Surg 24:169–178. doi:10.1089/pho.2006.24.169

    Article  PubMed  CAS  Google Scholar 

  4. Nicolau RA, Jorgetti V, Rigau J, Zangaro RA (2003) Effect of low-power GaAlAs laser (660 nm) on bone structure and cell activity: an experimental animal study. Laser Med Sci 18:89–94. doi:10.1007/s10103–003–0260-z

    Article  Google Scholar 

  5. Silva Junior AN, Pinheiro ALB, Oliveira MG, Weismann R, Ramalho PLM, Nicolau RA (2002) Computerized morphometric assessment of the effect of low level laser therapy on bone repair: an experimental animal study. J Clin Laser Med Surg 20:83–87. doi:10.1089/104454702753768061

    Article  PubMed  Google Scholar 

  6. Gerbi ME, Pinheiro ALB, Marzola C, Limera Junior FD, Ramalho LM, Ponzi EA, Soares AO (2005) Assessment of bone repair associated with the use of organic bovine bone and membrane irradiated at 830 nm. Photomed Laser Surg 23:382–388. doi:10.1089/pho.2005.23.382

    Article  PubMed  Google Scholar 

  7. Pinheiro AL, Nascimento SC, Vieira AL (2001) Effects of LLLT on malignant cells: study in vitro. In: Rechmann P, Fried D, Hennig T (eds) Lasers in dentistry VII. SPIE, Billingham, pp 56–60

    Google Scholar 

  8. Stein A, Benayahu D, Maltz L, Oron L (2005) Low level laser irradiation promotes proliferation and differentiation of human osteoblasts in vitro. Photomed Laser Surg 23:161–166. doi:10.1089/pho.2005.23.161

    Article  PubMed  CAS  Google Scholar 

  9. Luger EJ, Rochkind S, Wollman Y, Kogan G, Dekel S (1998) Effect of low power laser irradiation on the mechanical properties of bone fracture healing in rats. Lasers Surg Med 22:97–102. doi:10.1002/(SICI)1096–9101(1998)22:2<97::AID-LSM5>3.0.CO;2-R

    Article  PubMed  CAS  Google Scholar 

  10. Anneroth G, Hall G, Rydén H, Zetterqvist L (1988) The effect of low-energy infrared laser radiation on wound healing in rats. Br J Oral Maxillofac Surg 26:12–17

    Article  PubMed  CAS  Google Scholar 

  11. Friesen LR, Cobb CM, Rapley JW, Forgas-Brockman L, Spencer P (1999) Laser irradiation of bone: ll. Healing response following treatment by CO2 and Nd: YAG lasers. J Periodontol 70:75–83. doi:10.1902/jop.1999.70.1.75

    Article  PubMed  CAS  Google Scholar 

  12. Arosarena OA, Falk A, Malmgren L, Booman L, Allen MJ, Schoonmaker J, Tatum S, Kellman R (2003) Defect repair in the rat mandible with bone morphogenic proteins and marrow cells. Arch Facial Plast Surg 5:103–108

    Article  PubMed  Google Scholar 

  13. Khadra M, Kasem N, Haanes HR, Ellingsen JE, Lyngstadaas SP (2004) Enhancement of bone formation in rat calvarial bone defects using low level laser therapy. Oral Surg Oral Med Oral Path Oral Radiol Endod 97:693–700. doi:10.1016/j.tripleo.2003.11.008

    Article  Google Scholar 

  14. Dortbudak O, Haas R, Mailath PG (2000) Biostimulation of bone marrow cells with a diode soft laser. Clin Oral Implants Res 11:540–545. doi:10.1034/j.1600–0501.2000.011006540.x

    Article  PubMed  CAS  Google Scholar 

  15. Guzzardella GA, Tigani D, Torricelli P, Fini M, Martini L, Morrone G, Giardino R (2001) Low-power diode laser stimulation of surgical osteochondral defects. Results after 24 weeks. Artif Cells Blood Substit Immobil Biotechnol 29:235–244. doi:10.1081/BIO-100103047

    Article  PubMed  CAS  Google Scholar 

  16. Pinheiro AL, Júnior LD, Gerbi ME, Ramalho LM, Marzola C (2003) Effect of low level laser therapy on the repair of bone defects grafted with inorganic bovine bone. Braz Dent J 14:177–181

    PubMed  Google Scholar 

  17. Gordjestani M, Thierens DH (1994) Infrared laser and bone metabolism: a pilot study. Int J Oral Maxillofac Surg 23:54–56. doi:10.1016/S0901–5027(05)80329–7

    Article  PubMed  CAS  Google Scholar 

  18. Pogrel MA, Chen JW, Zhang K (1997) Effects of low-energy gallium-aluminum-arsenide laser irradiation on cultured fibroblasts and keratinocytes. Laser Surg Med 20:426–432. doi:10.1002/(SICI)1096–9101(1997)20:4<426::AID-LSM8>3.0.CO;2-S

    Article  CAS  Google Scholar 

  19. Morrone G, Guzzardela GA, Orientr K, Giavaresi G, Fini M, Racca M, Mortini L, Giardino R (1998) Muscular trauma treated with a Ga-Al-As diode laser: in vivo experimental study. Laser Med Sci 13:293–298. doi:10.1007/s101030050011

    Article  Google Scholar 

  20. Sommer AP, Pinheiro ALB, Mester A, Franke RP, Whelan HT (2001) Biostimulatory windows in low-intensity laser activation: lasers, scanners and NASA’s light-emitting diode array system. J Clin Laser Surg Med 19:29–34. doi:10.1089/104454701750066910

    Article  CAS  Google Scholar 

  21. Weber JB, Pinheiro AL, De Oliveira MG, Oliveira FA, Ramalho LM (2006) Laser therapy improves healing of bone defects submitted to autologous bone graft. Photomed Laser Surg 24:38–44. doi:10.1089/pho.2006.24.38

    Article  PubMed  Google Scholar 

  22. Rochkind S, Kogan G, Luger EG, Salame K (2004) Molecular structure of the bony tissue after experimental trauma to the mandibular region followed by laser therapy. Photomed Laser Surg 22:249–253. doi:10.1089/1549541041438579

    Article  PubMed  CAS  Google Scholar 

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Acknowledgements

The authors wish to acknowledge funding received for this study from the Egyptian Government for a Channel Link PhD Programme.

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Authors and Affiliations

  1. Department of Oral Medicine and Periodontology, Faculty of Dentistry, Mansoura University, Mansoura, Egypt

    Nayer S. AboElsaad, Laila M. A. Gadalla, Laila I. Ragab & Khaled R. Zalata

  2. Periodontology, King’s College London Dental Institute at GKT Hospitals, King’s College Dental Hospital, Denmark Hill, London, SE5 9RW, UK

    Mena Soory

  3. Primary Dental Care Department, King’s College London Dental Institute, London, UK

    Stephen Dunne

  4. Eastman CPD, UCL Eastman Dental Institute, London, UK

    Chris Louca

Authors
  1. Nayer S. AboElsaad
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  2. Mena Soory
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  3. Laila M. A. Gadalla
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  4. Laila I. Ragab
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  5. Stephen Dunne
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  6. Khaled R. Zalata
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  7. Chris Louca
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Correspondence to Mena Soory.

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AboElsaad, N.S., Soory, M., Gadalla, L.M.A. et al. Effect of soft laser and bioactive glass on bone regeneration in the treatment of bone defects (an experimental study). Lasers Med Sci 24, 527–533 (2009). https://doi.org/10.1007/s10103-008-0590-y

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  • DOI: https://doi.org/10.1007/s10103-008-0590-y

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