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Contemporary comparison of infective endocarditis caused by Candida albicans and Candida parapsilosis: a cohort study

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Abstract

Among 1655 consecutive patients with infective endocarditis treated from 1998 to 2020 in three tertiary care centres, 16 were caused by Candida albicans (CAIE, n = 8) and Candida parapsilosis (CPIE, n = 8). Compared to CAIE, CPIE were more frequently community-acquired. Prosthetic valve involvement was remarkably more common among patients with CPIE. CPIE cases presented a higher rate of positive blood cultures at admission, persistently positive blood cultures after antifungals initiation and positive valve cultures. All patients but four underwent cardiac surgery. Urgent surgery was more frequently performed in CPIE. No differences regarding in-hospital mortality were documented, even after adjusting for therapeutic management.

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Fig. 1
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Data availability

The datasets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.

Code availability

Not applicable.

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Funding

No funding, grants or other support was received for conducting this study.

Author information

Authors and Affiliations

  1. Instituto Cardiovascular, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdSSC), Prof. Martín Lagos s/n, 28040, Madrid, Spain

    Adrián Jerónimo, Carmen Olmos, Isidre Vilacosta & Pablo Zulet

  2. Servicio de Medicina Interna-Infecciosas, Instituto de Investigación Sanitaria del Hospital Universitario de la Princesa, Madrid, Spain

    Carmen Sáez, Marta Sanz & Javier B. Pérez-Serrano

  3. Servicio de Cardiología, Instituto de Ciencias del Corazón (ICICOR), CIBERCV, Hospital Clínico Universitario de Valladolid, Valladolid, Spain

    Javier López, Gonzalo Cabezón & J. Alberto San Román

Authors
  1. Adrián Jerónimo
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  2. Carmen Olmos
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  3. Isidre Vilacosta
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  4. Carmen Sáez
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  5. Javier López
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  6. Marta Sanz
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  7. Gonzalo Cabezón
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  8. Javier B. Pérez-Serrano
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  9. Pablo Zulet
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  10. J. Alberto San Román
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by Adrián Jerónimo, Carmen Olmos and Isidre Vilacosta. The first draft of the manuscript was written by Adrián Jerónimo, and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Carmen Olmos.

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Ethics approval

Approval was obtained from the ethics committee of Hospital Clínico San Carlos (Madrid, Spain), Local Ethics Committee approval number: 15/283-E. The procedures used in this study adhere to the tenets of the Declaration of Helsinki.

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Informed consent was obtained from all individual participants included in the study.

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Not applicable.

Conflict of interest

The authors declare no competing interests.

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Jerónimo, A., Olmos, C., Vilacosta, I. et al. Contemporary comparison of infective endocarditis caused by Candida albicans and Candida parapsilosis: a cohort study. Eur J Clin Microbiol Infect Dis 41, 981–987 (2022). https://doi.org/10.1007/s10096-022-04456-x

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  • DOI: https://doi.org/10.1007/s10096-022-04456-x

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