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Causal associations between 25-hydroxyvitamin D levels and NMOSD: a two-Sample Mendelian randomization analysis

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Fig. 1

Data availability

Data supporting the findings of this study are available from the article.

Abbreviations

NMOSD :

Neuromyelitis optica spectrum disorder

CNS :

Central nervous system

MR :

Mendelian randomization

25(OH)D :

25-Hydroxyvitamin D

GWAS :

Genome-wide association study

AQP-4 :

Aquaporin-4

Ab :

Antibody

UK :

United Kingdom

SNPs :

Single-nucleotide polymorphisms

LD :

Linkage disequilibrium

IVW :

Inverse variance weighted

MR-PRESSO :

MR Pleiotropy Residual Sum and Outlier

OR :

Odds ratio

CI :

Confidence intervals

Th :

T helper

References

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Acknowledgements

We acknowledge the investigators and participants of the original GWAS. We are grateful for all GWAS sharing summary data used in this study.

Funding

This work was supported by National Natural Science Foundation of China, 82371365, Qun Xue,Jiangsu Provincial Natural Science Foundation, BK20211075, Qun Xue, Soochow University Collaborative Innovation Centre, H230028, Qun Xue.

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Author notes

  1. Yunfei Zhu and Xiaoling Zhou contributed equally to this work.

Authors and Affiliations

  1. Department of Neurology, First Affiliated Hospital of Soochow University, Suzhou, 215000, Jiangsu, China

    Yunfei Zhu, Jingjin Jia & Qun Xue

  2. Department of Neurology, Suzhou Municipal Hospital, Suzhou, 215000, Jiangsu, China

    Xiaoling Zhou

  3. Suzhou Clinical Medical Centre, Suzhou, 215000, Jiangsu, China

    Qun Xue

Authors
  1. Yunfei Zhu
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  2. Xiaoling Zhou
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  3. Jingjin Jia
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  4. Qun Xue
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Corresponding author

Correspondence to Qun Xue.

Ethics declarations

Ethical approval

Since the GWAS data from published studies were used for the study, there was no need for additional ethical approval.

Informed consent

All analyses were performed using publicly available GWAS datasets. The GWAS studies cited in this research have received approval from their respective ethical review boards and have complied with informed consent requirements from participants.

Competing interests

The authors declare no competing interests.

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Zhu, Y., Zhou, X., Jia, J. et al. Causal associations between 25-hydroxyvitamin D levels and NMOSD: a two-Sample Mendelian randomization analysis. Neurol Sci 45, 2379–2381 (2024). https://doi.org/10.1007/s10072-023-07290-x

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  • DOI: https://doi.org/10.1007/s10072-023-07290-x

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