Skip to main content
SpringerLink
Log in

Safety and efficacy of intravenous thrombolysis in patients with acute stroke and active cancer: retrospective cohort study

  • Letter to the Editor
  • Published:
Neurological Sciences Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Availability of data and material

N/A.

Code availability

N/A.

References

  1. Powers WJ, Rabinstein AA, Ackerson T et al (2019) Guidelines for the early management of patients with acute ischemic stroke: 2019 update to the 2018 guidelines for the early management of acute ischemic stroke: a guideline for healthcare professionals from the American heart association/American stroke association [published correction appears in Stroke. 2019 Dec, 50(12), pp. e440–e441]. Stroke 50:e344–e418

    Article  Google Scholar 

  2. Berge E, Whiteley W, Audebert H et al (2021) European Stroke Organisation (ESO) guidelines on intravenous thrombolysis for acute ischaemic stroke. Eur Stroke J 6(1):I–LXII

    Article  Google Scholar 

  3. Yaghi S, Willey JZ, Cucchiara B et al (2017) Treatment and outcome of hemorrhagic transformation after intravenous alteplase in acute ischemic stroke: a scientific statement for healthcare professionals from the american heart association/American stroke association. Stroke 48(12):e343–e361

    Article  Google Scholar 

  4. Kneihsl M, Enzinger C, Wünsch G et al (2016) Poor short-term outcome in patients with ischaemic stroke and active cancer. J Neurol 263:150–156

    Article  CAS  Google Scholar 

  5. Newton HB (1999) Neurologic complications of systemic cancer [published correction appears in Am Fam Physician 1999 May 1;59(9):2435]. Am Fam Physician 59:878–886

    CAS  PubMed  Google Scholar 

  6. Grisold W, Oberndorfer S, Struhal W (2009) Stroke and cancer: a review. Acta Neurol Scand 119:1–16

    Article  CAS  Google Scholar 

  7. Dardiotis E, Aloizou AM, Markoula S, Siokas V, Tsarouhas K, Tzanakakis G et al (2019) Cancer-associated stroke: pathophysiology, detection and management (Review). Int J Oncol 54:779–796

    CAS  PubMed  PubMed Central  Google Scholar 

  8. Lee AY, Levine MN, Baker RI et al (2003) Randomized comparison of low-molecular-weight heparin versus oral anticoagulant therapy for the prevention of recurrent venous thromboembolism in patients with cancer (CLOT) investigators. Low-molecular-weight heparin versus a coumarin for the prevention of recurrent venous thromboembolism in patients with cancer. N Engl J Med. 349(2):146–53

    Article  CAS  Google Scholar 

  9. Ladak AA, Sandhu S, Itrat A (2021) Use of intravenous thrombolysis in acute ischemic stroke management in patients with active malignancies: a topical review. J Stroke Cerebrovasc Dis. 30(6):105728. https://doi.org/10.1016/j.jstrokecerebrovasdis.2021.105728 (Epub 2021 Mar 18. PMID: 33743410)

    Article  PubMed  Google Scholar 

  10. Eikelboom JW, Connolly SJ, Bosch J, Shestakovska O, Aboyans V, Alings M, Anand SS, Avezum A, Berkowitz SD, Bhatt DL, Cook-Bruns N, Felix C, Fox KAA, Hart RG, Maggioni AP, Moayyedi P, O’Donnell M, Rydén L, Verhamme P, Widimsky P, Zhu J, Yusuf S (2019) Bleeding and new cancer diagnosis in patients with atherosclerosis. Circulation 140:1451–1459

    Article  CAS  Google Scholar 

  11. Rumalla K, Mittal MK (2016) Gastrointestinal bleeding in acute ischemic stroke: a population-based analysis of hospitalizations in the United States. J Stroke Cerebrovasc Dis 25:1728–1735

    Article  Google Scholar 

  12. Yoo J, Nam HS, Kim YD, Lee HS, Heo JH (2019) Stroke. Short-term outcome of ischemic stroke patients with systemic malignancy 50:507–511

    Google Scholar 

  13. Thomalla G, Simonsen CZ, Boutitie F et al (2018) WAKE-UP Investigators. MRI-guided thrombolysis for stroke with unknown time of onset. N Engl J Med. 379(7):611–622. https://doi.org/10.1056/NEJMoa1804355 (Epub 2018 May 16. PMID: 29766770)

    Article  PubMed  Google Scholar 

  14. Ma H, Campbell BCV, Parsons MW et al (2019) EXTEND investigators. Thrombolysis guided by perfusion imaging up to 9 hours after onset of stroke. N Engl J Med. 380(19):1795–1803. https://doi.org/10.1056/NEJMoa1813046 (Erratum in: N Engl J Med. 2021 Apr 1;384(13):1278. PMID: 31067369)

    Article  PubMed  Google Scholar 

  15. Benedict CR, Refino CJ, Keyt BA et al (1995) New variant of human tissue plasminogen activator (tpa) with enhanced efficacy and lower incidence of bleeding compared with recombinant human tpa. Circulation 92:3032–3040

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Internal, Vascular and Emergency Medicine-Stroke Unit, Università Degli Studi Di Perugia/Azienda Ospedaliera Santa Maria Della Misericordia, 06129, Perugia, Italy

    Maria Giulia Mosconi, Andrea Capponi, Patrizia Pierini, Valeria Caso & Maurizio Paciaroni

Authors
  1. Maria Giulia Mosconi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Andrea Capponi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Patrizia Pierini
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Valeria Caso
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Maurizio Paciaroni
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

MGM conceptualized and supervised the manuscript; wrote, edited, and finalized the manuscript.

AC conceptualized and supervised the manuscript; wrote, edited, and finalized the manuscript.

PP edited and finalized the manuscript.

VC edited and finalized the manuscript.

MP conceptualized and supervised the manuscript; wrote, edited, and finalized the manuscript.

Corresponding author

Correspondence to Maria Giulia Mosconi.

Ethics declarations

Conflict of interest

The authors declare no competing interests.

Ethics approval

The study was approved by the pertinent institutional review board.

Informed consent

Informed consent was obtained from all patients.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Mosconi, M.G., Capponi, A., Pierini, P. et al. Safety and efficacy of intravenous thrombolysis in patients with acute stroke and active cancer: retrospective cohort study. Neurol Sci 43, 4003–4006 (2022). https://doi.org/10.1007/s10072-022-06026-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10072-022-06026-7

Search

Navigation