Skip to main content

Advertisement

SpringerLink
Log in

Video analysis of long-term effects of levodopa-carbidopa intestinal gel on gait and posture in advanced Parkinson’s disease

  • Brief Communication
  • Published:
Neurological Sciences Aims and scope Submit manuscript

Abstract

Gait and posture parameters of ten advanced Parkinson’s disease (PD) patients were assessed before and after starting levodopa-carbidopa intestinal gel (LCIG) treatment by means of both objective video analysis and clinical assessment. After 3 years of treatment, gait and posture remained stable. A slower gait velocity at baseline significantly correlates with a higher axial and motor severity at follow-up. This pilot study suggests that validated video analysis software may support the clinical assessment of axial signs in PD patients who are candidates for device-aided therapies.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

References

  1. Zibetti M, Angrisano S, Dematteis F, Artusi CA, Romagnolo A, Merola A, Lopiano L (2018) Effects of intestinal levodopa infusion on freezing of gait in Parkinson disease. J Neurol Sci 385:105–108. https://doi.org/10.1016/j.jns.2017.12.012

    Article  CAS  PubMed  Google Scholar 

  2. Rispoli V, Golfre Andreasi N, Penna G, Preda F, Contini E, Sensi M (2018) Levodopa/carbidopa intestinal gel infusion therapy: focus on gait and balance. Mov Disord Clin Pract 5(5):542–545. https://doi.org/10.1002/mdc3.12640

    Article  PubMed  PubMed Central  Google Scholar 

  3. Fabbri MCP, Artusi CA, Romagnolo A, Rizzone MG, Zibetti M, Lopiano L (2019) Long-term effect of levodopa-carbidopa intestinal-gel on axial signs in Parkinson’s disease. Acta neurologica Scandinavica:Epub ahead of print

  4. Hughes AJ, Daniel SE, Kilford L, Lees AJ (1992) Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry 55(3):181–184

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Guzmán-Valdivia CHB-OA, Oliver-Salazar MA, Carrera-Escobedo JL (2013) Therapeutic motion analysis of lower limbs using Kinovea. Int J Soft Comput Eng 3:359–365

    Google Scholar 

  6. Yoshii F, Moriya Y, Ohnuki T, Ryo M, Takahashi W (2016) Postural deformities in Parkinson's disease -mutual relationships among neck flexion, fore-bent, knee-bent and lateral-bent angles and correlations with clinical predictors. J Clin Mov Disord 3:1. https://doi.org/10.1186/s40734-016-0029-8

    Article  PubMed  PubMed Central  Google Scholar 

  7. Margraf NG, Wolke R, Granert O, Berardelli A, Bloem BR, Djaldetti R, Espay AJ, Fasano A, Furusawa Y, Giladi N, Hallett M, Jankovic J, Murata M, Tinazzi M, Volkmann J, Berg D, Deuschl G (2018) Consensus for the measurement of the camptocormia angle in the standing patient. Parkinsonism Relat Disord 52:1–5. https://doi.org/10.1016/j.parkreldis.2018.06.013

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

The authors thank all the patients and their families for participating in this study.

Author information

Author notes

  1. Margherita Fabbri and Chatkaew Pongmala contributed equally to this work.

Authors and Affiliations

  1. Department of Neuroscience “Rita Levi Montalcini”, University of Torino, Via Cherasco 15, 10124, Turin, Italy

    Margherita Fabbri, Chatkaew Pongmala, Carlo Alberto Artusi, Gabriele Imbalzano, Alberto Romagnolo, Leonardo Lopiano & Maurizio Zibetti

  2. Instituto de Medicina Molecular, Faculty of Medicine, University of Lisbon, Lisbon, Portugal

    Margherita Fabbri

Authors
  1. Margherita Fabbri
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Chatkaew Pongmala
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Carlo Alberto Artusi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Gabriele Imbalzano
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Alberto Romagnolo
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Leonardo Lopiano
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Maurizio Zibetti
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Maurizio Zibetti.

Ethics declarations

Conflict of interest

Dr. Margherita Fabbri: no conflict of interest to report. Stock ownership in medically related fields: none. Consultancies: none. Advisory boards: none. Partnership: none. Honoraria to speak: none. Grants: AbbVie. Intellectual property rights: none. Expert testimony: none. Contracts: none. Royalties: none. Other: none

Chatkaew Pongmala: no conflict of interest to report. Stock ownership in medically related fields: none. Consultancies: none. Advisory boards: none. Partnership: none. Honoraria to speak: none. Grants: none. Intellectual property rights: none. Expert testimony: none. Contracts: none. Royalties: none. Other: none

Dr. Carlo Alberto Artusi: no conflict of interest to report. Stock ownership in medically related fields: none. Honoraria to speak and grants: Neuraxpharm, Zanbom, and AbbVie. Advisory boards: none. Partnership: none. Intellectual property rights: none. Expert testimony: none. Contracts: none. Royalties: none. Other: none

Dr. Gabriele Imbalzano: no conflict of interest to report. Stock ownership in medically related fields: none. Honoraria to speak and grants: none. Advisory boards: none. Partnership: none. Intellectual property rights: none. Expert testimony: none. Contracts: none. Royalties: none. Other: none

Dr. Alberto Romagnolo: no conflict of interest to report. Grant support and speaker honoraria from AbbVie and speaker honoraria from Chiesi Farmaceutici and travel grants from Lusofarmaco, Chiesi, Medtronic, and UCB Pharma. Expert testimony: none. Contracts: none. Royalties: none. Other: none

Prof. Leonardo Lopiano: no conflict of interest to report. Stock Ownership in medically related fields: none. Honoraria to speak and grants: Medtronic, UCB Pharma, AbbVie, and Doc Generici. Advisory boards: none. Partnership: none. Intellectual property rights: none. Expert testimony: none. Contracts: none. Royalties: none. Other: none

Dr. Maurizio Zibetti: no conflict of interest to report. Stock Ownership in medically related fields: none. Honoraria to speak and grants: Medtronic, Lundbeck, UCB Pharma, and AbbVie. Advisory boards: none. Partnership: none. Intellectual property rights: none. Expert testimony: none. Contracts: none. Royalties: none. Other: none

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Electronic supplementary material

ESM 1

(DOCX 13 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Fabbri, M., Pongmala, C., Artusi, C.A. et al. Video analysis of long-term effects of levodopa-carbidopa intestinal gel on gait and posture in advanced Parkinson’s disease. Neurol Sci 41, 1927–1930 (2020). https://doi.org/10.1007/s10072-020-04319-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10072-020-04319-3

Keywords

Search

Navigation