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Evaluation of cortical thickness and brain volume on 3 Tesla magnetic resonance imaging in children with frontal lobe epilepsy

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Abstract

Background

Frontal lobe epilepsy (FLE) is the most common epilepsy syndrome in the pediatric population; however, brain magnetic resonance imaging (MRI) of the children with FLE is frequently normal. We use both cortical thickness and brain volume measurements to report on cortical changes in children with FLE. Our aim was to determine cortical thickness and brain volume changes on 3 Tesla MRI of children with FLE and normal brain magnetic resonance imaging.

Methods

Twenty-seven children with FLE and 27 healthy controls received brain magnetic resonance imaging. Cortical thickness and regional brain volumes were assessed using three-dimensional volumetric T1-weighted imaging and patients were compared with controls.

Results

In children with FLE, statistically significant (p < 0.05) cortical thinning were found in the bilateral middle frontal gyrus, bilateral occipitotemporal and medial lingual gyrus, left subcallosal gyrus, left short insular gyrus, and right long insular gyrus. Statistically significant volume reductions in right and left hemisphere cortical white matter, total cortical white matter, bilateral thalamus, bilateral putamen, bilateral globus pallidus, right caudate nucleus, brain stem, and right cerebellar cortex were found.

Conclusion

Cortical thinning in frontal and extra-frontal lobes and volume loss in a variety of brain regions were found in children with FLE.

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Authors and Affiliations

  1. Department of Radiology, Faculty of Medicine, Baskent University, 10. Sokak No:45, 06490, Bahcelievler, Ankara, Turkey

    Feride Kural Rahatli

  2. Department of Pediatric Neurology, Faculty of Medicine, Baskent University, 10. Sokak No:45, 06490, Bahcelievler, Ankara, Turkey

    Taner Sezer

  3. UMRAM (National Magnetic Resonance Research Center), Bilkent University, Bilkent Cyberpark, Bilkent 6. Cadde, 06800, Ankara, Turkey

    Arzu Ceylan Has

  4. Department of Radiology, Faculty of Medicine, Baskent University, 10. Sokak No:45, 06490, Bahcelievler, Ankara, Turkey

    Ahmet Muhtesem Agildere

Authors
  1. Feride Kural Rahatli
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  2. Taner Sezer
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Correspondence to Feride Kural Rahatli.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of our institutional review board (IRB) after its approval and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Our IRB determined that patient approval and informed consent were not required because of retrospectively reviewing images and records.

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Rahatli, F.K., Sezer, T., Has, A.C. et al. Evaluation of cortical thickness and brain volume on 3 Tesla magnetic resonance imaging in children with frontal lobe epilepsy. Neurol Sci 41, 825–833 (2020). https://doi.org/10.1007/s10072-019-04135-4

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  • DOI: https://doi.org/10.1007/s10072-019-04135-4

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