Abstract
Post-stroke anxiety (PSA) is a common neuropsychiatric affective disorder occurring after stroke. The purpose of this study was to investigate the association between anxiety and the serum levels of oxidative stress markers at admission. First-ever or recurrent ischemic stroke patients were consecutively recruited into the study and followed up 1 month. Patients were divided into PSA and non-PSA group according DSM-IV criteria for anxiety due to stroke. Overall, 49 patients (24.1%) were diagnosed anxiety. Serum GPX (glutathione peroxidase), CAT (catalase), SOD (superoxide dismutase), and MDA (malondialdehyde) were significantly higher in patients with anxiety than patients without anxiety. The HAM-A scores had a significant positive association with MDA levels. In multivariate logistic regression analysis, serum antioxidant enzymes and MDA were independent predictors of PSA. An increased risk of PSA was associated with serum MDA levels ≥ 3.0 nmol/ml (adjusted OR 8.68, 95% CI 3.02–24.95; P < 0.001) after adjusting for relevant confounders such as social support and treatments at admission. Elevated serum levels of lipid oxidation products and antioxidant enzymes at admission were associated with anxiety 1 month after stroke, suggesting that these alterations might participate in the pathophysiology of anxiety symptoms in stroke patients.
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Abbreviations
- BMI:
-
Body mass index
- SBP:
-
Systolic blood pressure
- DBP:
-
Diastolic blood pressure
- NIHSS:
-
National Institutes of Health Stroke Scale
- MMSE:
-
Mini-mental state examination
- PSQI:
-
Pittsburgh Sleep Quality Index
- SSRS:
-
Social Support Rating Scale
- BI:
-
Modified Barthel Index
- PSA:
-
Post-stroke anxiety
- FBG:
-
Fasting blood glucose
- TG:
-
Total cholesterol
- Hs-CRP:
-
High-sensitivity C-reactive protein
- GPX:
-
Glutathione peroxidase
- CAT:
-
Catalase
- SOD:
-
Superoxide dismutase
- MDA:
-
Malondialdehyde
- 95% CI:
-
95% Confidence interval
- OR:
-
Odds ratio
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Funding
This work was supported by the National Key Technology Research and Development Program of the Ministry of Science and Technology of China (grant number: 2015BAI13B01) and Wenzhou Municipal Sci-Tech Bureau Program (grant number:Y20160002).
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Liu, Z., Cai, Y., Zhang, X. et al. High serum levels of malondialdehyde and antioxidant enzymes are associated with post-stroke anxiety. Neurol Sci 39, 999–1007 (2018). https://doi.org/10.1007/s10072-018-3287-4
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DOI: https://doi.org/10.1007/s10072-018-3287-4