Abstract
Ophthalmoplegia without ataxia, areflexia or both has been designated as atypical Miller Fisher syndrome (MFS) or acute ophthalmoplegia (AO). This entity, first reported by Chiba et al. is associated with anti-GQ1b IgG antibodies.We report a patient with isolated acute ophthalmoplegia with high titer of anti-GQ1b IgG antibody activity in the acute phase in whom treatment with intravenous immunoglobulin (IVIg) led to the clinical recovery and the decrease in antibody titer.
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References
Chiba A, Kusunoki S, Obata H, Machinami R, Kanazawa I (1993) Serum anti-GQ1b IgG antibody is associated with ophthalmoplegia in Miller Fisher syndrome and Guillain Barré syndrome: clinical and immunohistochemical studies. Neurology 43:1911–1917
Yuki N (1996) Acute paresis of extraocular muscles associated with IgG anti-GQ1b antibody. Ann Neurol 39:668–672
Odaka M, Yuki N, Hirata K (2001) Anti-GQ1b antibody syndrome: clinical and immunological range. J Neurol Neurosurg Psychiatry 70:50–55
Hao Q, Saida T, Kuroki S, Nishimura M, Nukina M, Obayashi H, Saida K (1998) Antibodies to gangliosides and galactocerebroside in patients with Guilllain-Barré syndrome with preceding Campylobacter Jejuni and other identified infections. J Neuroimmunol 81:116–126
Plomp JJ, Molenaar PC, O’Hanlon GM, Jacobs BC, Veitch J, Daha MR, van Doorn PA, van der Meché FG, Vincent A, Morgan BP, Willison HJ (1999) Miller Fisher anti-GQ1b antibodies: α-latrotoxin-like effects on motor end plates. Ann Neurol 45:189–199
Radziwill AJ, Steck AJ, Borruat FX, Bogousslavsky J (1998) Isolated internal ophthalmoplegia associated with IgG anti-GQ1b antibody. Neurology 50:307
Kikuchi M, Tagawa Y, Saotome S, Nonoyama T, Hoshino H, Yuki N (1997) Acute ophthalmoparesis is associated with IgG anti-GQ1b antibody subsequent to Streptococcus Pyogenes infection. Eur J Paediatr Neurol 1:47–48
Lee SH, Lim GH, Kim JS, Oh SY, Kim JK, Cha JK, Yun CH, Kang JK, Lee H, Song HK, Chung KC (2008) Acute ophthalmoplegia (without ataxia) associated with anti-GQ1b antibody. Neurology 71(6):426–429
Kuroki S, Saida T, Nukina M, Yoshioka M, Seino J (2001) Three patients with ophthalmoplegia associated with Campylobacter jejuni. Pediatr Neurol 25(1):71–74
Goffette S, Sindic CJ (2000) Acute isolated ophthalmoplegia associated with high levels of anti-GQ1b antibodies. Eur Neurol 43(2):120–121
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Rigamonti, A., Lauria, G., Longoni, M. et al. Acute isolated ophthalmoplegia with anti-GQ1b antibodies. Neurol Sci 32, 681–682 (2011). https://doi.org/10.1007/s10072-011-0492-9
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DOI: https://doi.org/10.1007/s10072-011-0492-9