Abstract
Rheumatoid arthritis (RA) is an autoimmune inflammatory disease with an increased prevalence in Mexico. Although its etiology is unknown, its development can be influenced by environmental factors such as smoking and viral infections. But among the factors influencing susceptibility, it is the genetic factors that predominate, mainly the HLA-DRB1 genes, and specifically the alleles that have the shared epitope (SE). A transversal study was performed, in which 31 patients (28 women and 3 men) with RA, treated at the autoimmunity clinic of the High Specialty Hospital Ciudad Salud in Tapachula, Chiapas, southern México, were enrolled. Clinical, biochemical, and demographic data were analyzed; ESR (erythrocyte sedimentation rate), CRP (C-reactive protein), RF (rheumatoid factor), and ACPA (anticitrullinated peptide antibody) were recorded. All patients had at least one positive RA biological marker. For HLA alleles frequencies comparison, we enrolled ethnically matched healthy controls in a ratio of 3:1 for 25 cases and 4:1 for 6 cases in order to guarantee the balance between groups regarding the mean of age and proportion of gender (males vs females). HLA-DRB1*04 was found to be significantly increased in patients compared with ethnically matched healthy controls (p 0.0007, OR: 2.8, 95% CI 1.5–5.1); contrarily, DRB1*08 showed a protective effect (p 0.005, OR 0.1). This paper confirmed the involvement of HLA genes on risk determination for RA in a population of Mexican Mestizos from Tapachula, Chiapas.
Key Points • HLA-DRB1*04 confirms the increased risk of rheumatoid arthritis. • HLA-DRB1*08 showed a more definite protective effect in southern Mexicans mestizos, a population with more Amerindian ancestry. |
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Acknowledgments
We acknowledge the support of Dr. Fernando Tapia Garduño, Research, Planning and Education Director of the Centro Regional de Alta Especialidad de Chiapas.
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The authors confirm that the data supporting the findings of this study are available within the article. For detailed information of data bases, you may contact Dr. Jesus Sepulveda at jesussd52@gmail.com.
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This study was funded with research resources provided by the Federal Government and assigned to the Centro Regional de Alta Especialidad de Chiapas in 2018 and 2019.
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This study was approved by the Hospital Regional de Alta Especialidad ethics and research committee and has been performed in accordance with the ethical standards of 1964 Declaration of Helsinki, and all subjects were of adult age and signed an informed consent.
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Sepúlveda-Delgado, J., Rizo-Pinto, A., Granados-Arriola, J. et al. Role of HLA-DRB1*04 in the susceptibility and HLA-DRB1*08 in the protection for development of rheumatoid arthritis in a population of Southern Mexico: brief report. Clin Rheumatol 39, 2875–2879 (2020). https://doi.org/10.1007/s10067-020-05060-0
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DOI: https://doi.org/10.1007/s10067-020-05060-0