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How much gloom is in groans? Depression and its determinants in Nigerian patients with knee osteoarthritis: a multi-center cross-sectional study

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Abstract

Objectives

To determine the prevalence of depression and its determinants among Nigerian patients with knee osteoarthritis (OA).

Methods

Two hundred and fifty patients satisfying the American College of Rheumatology classification criteria for knee OA were recruited from five centers. Pain was assessed using Western Ontario and McMaster Universities Index (WOMAC) pain subscale, functional status was determined by Steinbrokers criteria, radiographic knee OA was graded using Kellgren–Lawrence criteria, depression was determined using the Patient Health Questionnaire (PHQ-9), sleep quality by the Pittsburgh Sleep Quality Index (PSQI), and family functioning by Family APGAR (Adaptation, Partnership, Growth, Affection, and Resolve). Factors associated with depression in KOA following bivariate analyses were adopted as independent variables in logistic regression analysis to determine the predictors of depression in KOA. The study was approved by the Ethical Review Committee of each of the study centers.

Results

The mean age of patients was 59.90 ± 10.62 years and 209 (83.6%) were females. Their mean PHQ-9 score was 4.68 ± 4.19 with 105 (42%) having depression (PHQ-9 ≥ 5). Eighty-four (80%) of patients with depression had poor sleep quality (PSQI≥ 5.0). Depression was significantly associated with poor sleep, WOMAC pain scores, medial compartment KOA, lateral compartment KOA, and patellofemoral OA. Poor sleep quality was the best predictor of depression (OR 4.555, CI (2.241–9.257), p < 0.001) followed by moderate to severe pain (OR 2.490, CI (1.119–5.542), p < 0.025).

Conclusion

Depression is common among patients with knee OA, and depression can be predicted by poor sleep quality and moderate to severe pain.

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Acknowledgements

We are grateful to the radiographers and radiologists that took and interpret the radiographs of the participants.

Author information

Authors and Affiliations

  1. Department of Medicine, University of Ilorin Teaching Hospital, Ilorin, Nigeria

    Richard Oluyinka Akintayo

  2. Department of Medicine, University of Maiduguri Teaching Hospital, Maiduguri, Borno State, Nigeria

    Abubakar Yerima

  3. Department of Medicine, Jos University Teaching Hospital, Jos, Nigeria

    Hakeem Babatunde Olaosebikan

  4. Department of Internal Medicine, University of Uyo Teaching Hospital, Uyo, Akwa Ibom State, Nigeria

    Courage Uhunmwangho

  5. Department of Medicine, Lagos State University Teaching Hospital, 1-5 Oba Akinjobi way, GRA, Ikeja, Lagos, Nigeria

    Akpabio Akanimo Akpabio

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  1. Richard Oluyinka Akintayo
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  5. Akpabio Akanimo Akpabio
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Correspondence to Abubakar Yerima.

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The study was approved by the Ethical Review Committee of each of the study centers.

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Akintayo, R.O., Yerima, A., Olaosebikan, H.B. et al. How much gloom is in groans? Depression and its determinants in Nigerian patients with knee osteoarthritis: a multi-center cross-sectional study. Clin Rheumatol 38, 1971–1978 (2019). https://doi.org/10.1007/s10067-019-04497-2

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  • DOI: https://doi.org/10.1007/s10067-019-04497-2

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