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Urinary interleukin 22 binding protein as a marker of lupus nephritis in Egyptian children with juvenile systemic lupus erythematosus

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Abstract

Juvenile systemic lupus erythematosus (JSLE) is a multi-system autoimmune inflammatory disease. Generally, 60% of patients will develop lupus nephritis (LN); thus, early recognition and treatment is associated with better outcome. Interleukin 22 (IL-22) is involved in tissue inflammation and is regulated by interleukin 22 binding protein (IL-22BP). This study aimed to use IL-22BP as a non-invasive marker for disease activity in JSLE and LN. This is a cross-sectional study conducted on 82 subjects: 51 JSLE patients and 31 healthy controls of matched age and gender. Urinary IL-22BP was measured using enzyme-linked immunosorbent assay, and its level was correlated with different clinical and laboratory data in JSLE as well as Systemic Lupus Erythematous Disease Activity Index 2000 (SLEDAI-2k), renal SLEDAI-2k, and Systemic Lupus International Collaborating Clinics (SLICC) renal activity score which were used to assess overall disease and renal activity. Our results showed that urinary IL-22BP level was significantly higher in JSLE patients with mean level of 4.13 ± 1.10, as compared to controls 1.63 ± 0.61 (P value < 0.001); also, patients with active LN had urinary levels of IL-22BP (5.47 ± 1.03) higher than patients with active JSLE without LN (4.23 ± 0.72) and patients with non-active JSLE/LN (3.5 ± 0.65) with a highly significant P value < 0.001. There was a positive correlation with SLEDAI-2k, renal SLEDAI, and renal activity scores (P < 0.001). Urinary IL-22BP may be used as a non-invasive marker for assessment of disease activity in children with JSLE and LN.

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Authors and Affiliations

  1. Pediatric Department, Faculty of Medicine, Cairo University, Kasr El Aini St. postal code, Cairo, 1157, Egypt

    Ahmed Mohamed Mahmoud Badr, Yomna Farag & Maie Abdelshafy

  2. Clinical Pathology Department, Faculty of Medicine, Cairo University, Cairo, Egypt

    Nermine Magdi Riad

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  1. Ahmed Mohamed Mahmoud Badr
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  2. Yomna Farag
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  3. Maie Abdelshafy
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  4. Nermine Magdi Riad
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Correspondence to Nermine Magdi Riad.

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The authors declare that the procedures followed were in accordance with the regulations of the responsible Clinical Research Ethics Committee and in accordance with those of the World Medical Association and the Helsinki Declaration.

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Badr, A.M.M., Farag, Y., Abdelshafy, M. et al. Urinary interleukin 22 binding protein as a marker of lupus nephritis in Egyptian children with juvenile systemic lupus erythematosus. Clin Rheumatol 37, 451–458 (2018). https://doi.org/10.1007/s10067-017-3812-5

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  • DOI: https://doi.org/10.1007/s10067-017-3812-5

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