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No effect of physiotherapy on the serum levels of adipocytokines in patients with ankylosing spondylitis

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Abstract

To investigate the effect of intensive physiotherapy on disease activity and serum levels of adipocytokines in patients with ankylosing spondylitis (AS). Twenty-six patients with AS were included in this study. Intensive physiotherapy was performed twice a week for a period of 3 months. The Bath AS Disease Activity Index (BASDAI) and the Bath AS Functional Index (BASFI) were assessed at inclusion and after 3 months. Leptin, adiponectin, resistin and visfatin serum levels were analysed by ELISA assays. Patients had mild to moderate disease activity. Baseline levels of adipocytokines did not correlate with indicators of disease activity, functional status or acute-phase reactants. After the 3 months of intensive physiotherapy, BASDAI significantly decreased from 2.98 to 1.8 (p = 0.01) and BASFI improved from 2.31 to 1.37 (p = 0.05), while there were no changes in serum levels of CRP, ESR and adipocytokines. In addition, baseline levels of adipocytokines did not predict the change of disease activity or functional ability. Intensive physiotherapy effectively reduces all clinical measures of disease activity, but it is not associated with a significant change in acute-phase reactants or serum levels of adipocytokines.

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Acknowledgments

This work was supported by MH CR—research project nos. 00023728 and by MSM 0021620864

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Authors and Affiliations

  1. Institute of Rheumatology, Department of Experimental and Clinical Rheumatology, Prague, Czech Republic

    Hana Hulejová, Markéta Kuklová, Karel Pavelka, Jiří Vencovský & Ladislav Šenolt

  2. Department of Sports Medicine and Adapted Physical Education, Faculty of Physical Education and Sport, Charles University, Prague, Czech Republic

    Andrea Levitová

  3. Department of Kinanthropology, Charles University, Prague, Czech Republic

    Jan Štochl

  4. Third Department of Medicine, First Faculty of Medicine, Charles University, Prague, Czech Republic

    Martin Haluzík

  5. Institute of Rheumatology, Experimental Connective Tissue Research Laboratory, Na Slupi 4, 128 50, Prague 2, Czech Republic

    Hana Hulejová

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  1. Hana Hulejová
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  2. Andrea Levitová
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  4. Jan Štochl
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Correspondence to Hana Hulejová.

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Hulejová, H., Levitová, A., Kuklová, M. et al. No effect of physiotherapy on the serum levels of adipocytokines in patients with ankylosing spondylitis. Clin Rheumatol 31, 67–71 (2012). https://doi.org/10.1007/s10067-011-1773-7

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  • DOI: https://doi.org/10.1007/s10067-011-1773-7

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