Abstract
A suitable index is needed for hemolysis tests that use low-flow pumps, such as pediatric blood pumps or blood purification pumps. To create such an index, the present study investigates the change of plasma-free hemoglobin in the pump circuit with time and the change of the hemolysis rate with flow rate and impeller rotational speed. The results show that the hemolysis rate or the increase rate of the total free hemoglobin are suitable measures for hemolysis evaluation for low-flow pumps.
Similar content being viewed by others
References
Nevaril CG, Hellums JD, Alfrey CP Jr, Lynch EC. Physical effects in red blood cell trauma. AIChE J. 1969;15:707.
Leverett LB, Hellums JD, Alfrey CP, Lynch EC. Red blood cell damage by shear stress. Biophys J. 1972;12:257–73.
Hashimoto S. Erythrocyte destruction under periodically fluctuating shear rate: comparative study with constant shear rate. Artif Org. 1989;13:458–63.
Schima H, Wieselthaler G, Schwendenwein I, Losert U, Wolner E. A review and assessment of investigative methods for mechanically induced blood trauma: special aspects in rotary blood pumps. Heart Replac-Artif Heart. 1998;6:361–7.
Giersiepen M, Wurzinger LJ, Opitz R, Reul H. Estimation of shear stress-related blood damage in heart valve prostheses-in vitro comparison of 25 aortic valves. Int J Artif Org. 1990;13:300–6.
Nishida M, Yamane T, Tsukamoto Y, Ito K, Konishi Y, Masuzawa T, Tsukiya T, Endo S, Taenaka Y. Shear evaluation by quantitative flow visualization near the casing surface of a centrifugal blood pump. J Jap Soc Mech Eng C. 2002;45:981–8.
American Society for Testing and Materials. Standard practice for selection of blood for in vitro evaluation of blood pumps. ASTM F1830–97. 1997.
American Society for Testing and Materials. Standard practice for assessment of hemolysis in continuous flow blood pumps. ASTM F1841–97. 1997.
International Organization for Standard. Cardiovascular implants and extracorporeal systems-Centrifugal blood pumps. ISO 18242. 2016.
Acknowledgements
The authors express their gratitude to Senko Medical Instrument Mfg. Co. for providing the test pumps.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors declare no conflict of interest.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Yamane, T., Adachi, K., Kosaka, R. et al. Suitable hemolysis index for low-flow rotary blood pumps. J Artif Organs 24, 120–125 (2021). https://doi.org/10.1007/s10047-020-01218-4
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10047-020-01218-4