Abstract
Despite optimal management, we sometimes experience refractory hemolysis requiring extensive device speed reduction or continuous hemodiafiltration following Impella implantation. However, pre-procedural predictors of such a refractory hemolysis remain unknown. In this study, we investigated the pre-procedural factors, including the echocardiographic narrow angle between aortic and mitral annulus, associating with the occurrence of refractory hemolysis following Impella insertion. We enrolled 26 patients (71 years, 65% male) who received Impella insertion between March 2018 and November 2019. Among baseline characteristics, the angle between aortic and mitral annulus, < 126.5°, was an independent risk factor of refractory hemolysis with an adjusted hazard ratio of 7.840 (95% confidence interval 0.925–66.44) and was associated with lower 30-day survival (64% vs. 100%, p = 0.0116). The narrow angle between aortic and mitral annulus might be a useful tool to risk-stratify the occurrence of refractory hemolysis following Impella insertion.
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References
Burkhoff D, Sayer G, Doshi D, et al. Hemodynamics of mechanical circulatory support. J Am Coll Cardiol. 2015;66:2663–744.
Seyfarth M, Sibbing D, Bauer I, et al. A randomized clinical trial to evaluate the safety and efficacy of a percutaneous left ventricular assist device versus intra-aortic balloon pumping for treatment of cardiogenic shock caused by myocardial infarction. J Am Coll Cardiol. 2008;52:1584–8.
Ouweneel DM, Eriksen E, Seyfarth M, et al. Percutaneous mechanical circulatory support versus intra-aortic balloon pump for treating cardiogenic shock: meta-analysis. J Am Coll Cardiol. 2017;69:358–60.
Patel N, Sharma A, Dalia T, et al. Vascular complications associated with percutaneous left ventricular assist device placement: a 10-year US perspective. Catheteriz Cardiovasc Intervent. 2020;95(2):309–16.
Sibbald M, Dzavik V. Severe hemolysis associated with use of the Impella LP 25 mechanical assist device. Catheteriz Cardiovasc Intervent. 2012;80:840–4.
Tanawuttiwat T, Chaparro SV. An unexpected cause of massive hemolysis in percutaneous left ventricular assist device. Cardiovasc Revasc Med. 2013;14:66–7.
Cardozo S, Ahmed T, Belgrave K. Impella induced massive hemolysis: reemphasizing echocardiographic guidance for correct placement. Case Rep Cardiol. 2015;2015:464135.
Badiye AP, Hernandez GA, Novoa I, et al. Incidence of hemolysis in patients with cardiogenic shock treated with impella percutaneous left ventricular assist device. ASAIO J. 2016;62:11–4.
Apel J, Paul R, Klaus S, et al. Assessment of hemolysis related quantities in a microaxial blood pump by computational fluid dynamics. Artif Organs. 2001;25:341–7.
Konstantinou K, Keeble TR, Kelly PA, et al. Protected percutaneous coronary intervention with Impella CP in a patient with left main disease, severe left ventricular systolic dysfunction and established hemolysis. Cardiovasc Diagn Ther. 2019;9:194–9.
Esposito ML, Morine KJ, Annamalai SK, et al. Increased plasma-free hemoglobin levels identify hemolysis in patients with cardiogenic shock and a trans valvular micro-axial flow pump. Artif Organs. 2019;43:125–31.
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Nakamura, M., Imamura, T., Fukui, T. et al. Impact of the angle between aortic and mitral annulus on the occurrence of hemolysis during Impella support. J Artif Organs 23, 207–213 (2020). https://doi.org/10.1007/s10047-020-01172-1
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DOI: https://doi.org/10.1007/s10047-020-01172-1