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Research of differential expression of sIL1RAP in low-grade gliomas between children and adults

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Abstract

Glioma is the most common intracranial malignant tumor. Low-grade gliomas (LGG) occupy almost 80% in all of the gliomas. The prognosis of LGG in children is much better than in adult, however, the molecular mechanism is still unclear. In our investigation, it was first found that the level of soluble IL1RAP (sIL1RAP) was significantly higher in the LGG from children than that from adult. We also revealed that sIL1RAP could induce the apoptosis of U251. In cells with overexpression of sIL-1RAP, the cell proliferation promoted by IL-1 was significantly inhibited. These decreased tumor growth ability and better prognosis of low-grade gliomas in children patients than that in adult patients. The expression level of sIL1RAP may become one of the potential indexes for determining the prognosis of low-grade gliomas.

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Acknowledgements

Supported by National Natural Science Funding (31271119), Beijing, a high-level technical talents cultivation plan in the Beijing Municipal Planning Commission Funding (2013-3-045).

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Authors and Affiliations

  1. Department of Pediatric Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China

    Jintao He, Xiang Li, Wanchun Zhu, Yaxiong Yu & Jian Gong

  2. Beijing Neurosurgical Institute, Capital Medical University, Beijing, 100050, China

    Jian Gong

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  1. Jintao He
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  2. Xiang Li
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  4. Yaxiong Yu
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Correspondence to Jian Gong.

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He, J., Li, X., Zhu, W. et al. Research of differential expression of sIL1RAP in low-grade gliomas between children and adults. Brain Tumor Pathol 35, 19–28 (2018). https://doi.org/10.1007/s10014-017-0304-x

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  • DOI: https://doi.org/10.1007/s10014-017-0304-x

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