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A mixed choroid plexus papilloma and ependymoma

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Abstract

We report a novel case of a mixed choroid plexus papilloma (CPP) and ependymoma with cartilaginous differentiation. This kind of mixed tumor has not been previously reported in the English literature. The patient was a 5-year-old girl, who presented with a 1-week history of fever and numbness of the right lower limb. Magnetic resonance imaging of the brain with gadolinium revealed a heterogeneously enhancing mass in the occipital horn of the left lateral ventricle. Histologically, the tumor showed an intermixed CPP area and a low-grade papillary ependymoma-like area, which was studded with cartilage islands and psammoma bodies. In many foci, direct transition of CPP and ependymoma was observed, but there were no high-grade features. We report this novel case, describe the unique microscopic and immunohistochemical features, and speculate on the pathogenesis.

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Acknowledgments

This research was supported by a grant from the National Research Foundation of Korea (NRF) funded by the Korean Government (MSIP) (No. 2010-0028631).

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Authors and Affiliations

  1. Department of Pathology, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul, 110-799, Republic of Korea

    Yujin Lee, Seong Ik Kim & Sung-Hye Park

  2. Department of Neurosurgery, Seoul National University Children’s Hospital and College of Medicine, Seoul, Republic of Korea

    Seung-Ki kim

  3. Department of Radiology, Seoul National University Children’s Hospital and College of Medicine, Seoul, Republic of Korea

    In One Kim

  4. Neuroscience Institute, Seoul National University, College of Medicine, Seoul, Republic of Korea

    Sung-Hye Park

Authors
  1. Yujin Lee
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  2. Seong Ik Kim
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  3. Seung-Ki kim
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  4. In One Kim
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  5. Sung-Hye Park
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Corresponding author

Correspondence to Sung-Hye Park.

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There is no conflict of interest to declare.

Informed consent

Written informed consent was waived and the case report was approved by the Institutional Review Board (IRB No: 1201-032-394).

Authors’ contributions

Yujin Lee and Seong Ik Kim drafted the manuscript. SK Kim involved in clinical evaluation and surgical removal of the tumor. IO Kim involved radiological evaluation of the case and summarized radiological findings. SH Park analyzed pathological data, designed and supervised the case report, and co-wrote and edited the manuscript. All authors read and approved the final manuscript.

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Lee, Y., Kim, S.I., kim, SK. et al. A mixed choroid plexus papilloma and ependymoma. Brain Tumor Pathol 33, 147–150 (2016). https://doi.org/10.1007/s10014-015-0242-4

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  • DOI: https://doi.org/10.1007/s10014-015-0242-4

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