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Anaplastic meningioma with rapid growth after omental flap transposition: a case report and experimental study

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Abstract

Meningiomas occasionally display aggressive behavior, but the mechanisms of malignant transformation remain unclear. We encountered the case of a 65-year-old man with a 10-year history of recurrent meningioma. The patient had undergone multiple tumor resections, radiotherapy treatments, and reconstructive surgeries due to wound infection. After the third resection of the tumor and reconstruction with an omental flap, the tumor demonstrated rapid growth and lung metastasis. The final pathological diagnosis was anaplastic meningioma. Because the drastic change of the tumor was observed after omental flap transposition, we investigated the effect of the omentum on tumor cells and performed histopathological analyses of meningiomas using a mouse model. We found that meningioma cells have a high affinity to the omentum and show a growth advantage when co-cultured with adipocytes. Immunohistochemical staining revealed that meningioma cells adjacent to the omentum strongly expressed fatty acid-binding protein 4, a lipid transfer protein, in both mouse and human. Our results suggest that tumor cells can receive lipid supply from omental adipocytes, and the surrounding tissues may induce tumor progression. We conclude that although omental tissue is an ideal material for reconstruction surgery, close follow-up is recommended in meningioma patients when used for cranioplasty.

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References

  1. Dolecek TA, Propp JM, Stroup NE, Kruchko C (2012) CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2005–2009. Neuro Oncol 14(Suppl 5):v1–v49

    Article  PubMed Central  PubMed  Google Scholar 

  2. Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, Scheithauer BW, Kleihues P (2007) The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 114:97–109

    Article  PubMed Central  PubMed  Google Scholar 

  3. Black P, Kathiresan S, Chung W (1998) Meningioma surgery in the elderly: a case-control study assessing morbidity and mortality. Acta Neurochir (Wien) 140:1013–1016 discussion 1016–1017

    Article  CAS  Google Scholar 

  4. Black PM, Morokoff AP, Zauberman J (2008) Surgery for extra-axial tumors of the cerebral convexity and midline. Neurosurgery 62:1115–1121 discussion 1121–1113

    Article  PubMed  Google Scholar 

  5. Sanai N, Sughrue ME, Shangari G, Chung K, Berger MS, McDermott MW (2010) Risk profile associated with convexity meningioma resection in the modern neurosurgical era. J Neurosurg 112:913–919

    Article  PubMed  Google Scholar 

  6. Monleón D, Morales JM, Gonzalez-Segura A, Gonzalez-Darder JM, Gil-Benso R, Cerdá-Nicolás M, López-Ginés C (2010) Metabolic aggressiveness in benign meningiomas with chromosomal instabilities. Cancer Res 70:8426–8434

    Article  PubMed  Google Scholar 

  7. Perry A, Scheithauer BW, Stafford SL, Lohse CM, Wollan PC (1999) “Malignancy” in meningiomas: a clinicopathologic study of 116 patients, with grading implications. Cancer 85:2046–2056

    CAS  PubMed  Google Scholar 

  8. Harris AE, Lee JY, Omalu B, Flickinger JC, Kondziolka D, Lunsford LD (2003) The effect of radiosurgery during management of aggressive meningiomas. Surg Neurol 60:298–305 discussion 305

    Article  PubMed  Google Scholar 

  9. Huffmann BC, Reinacher PC, Gilsbach JM (2005) Gamma knife surgery for atypical meningiomas. J Neurosurg 102(Suppl):283–286

    Article  PubMed  Google Scholar 

  10. Stafford SL, Pollock BE, Foote RL, Link MJ, Gorman DA, Schomberg PJ, Leavitt JA (2001) Meningioma radiosurgery: tumor control, outcomes, and complications among 190 consecutive patients. Neurosurgery 49:1029–1037 discussion 1037–1028

    CAS  PubMed  Google Scholar 

  11. Delgado-Lopez PD, Martin-Velasco V, Castilla-Diez JM, Galacho-Harriero AM, Rodriguez-Salazar A (2009) Preservation of bone flap after craniotomy infection. Neurocirugia (Astur). Spain, p 124–131

  12. Auguste KI, McDermott MW (2006) Salvage of infected craniotomy bone flaps with the wash-in, wash-out indwelling antibiotic irrigation system. Technical note and case series of 12 patients. J Neurosurg 105:640–644

    Article  PubMed  Google Scholar 

  13. Bruce JN, Bruce SS (2003) Preservation of bone flaps in patients with postcraniotomy infections. J Neurosurg 98:1203–1207

    Article  PubMed  Google Scholar 

  14. Asai S, Kamei Y, Torii S (2004) One-stage reconstruction of infected cranial defects using a titanium mesh plate enclosed in an omental flap. Ann Plast Surg 52:144–147

    Article  PubMed  Google Scholar 

  15. Wilkosz S, Ireland G, Khwaja N, Walker M, Butt R, de Giorgio-Miller A, Herrick SE (2005) A comparative study of the structure of human and murine greater omentum. Anat Embryol (Berl) 209:251–261

    Article  Google Scholar 

  16. Nieman KM, Kenny HA, Penicka CV, Ladanyi A, Buell-Gutbrod R, Zillhardt MR, Romero IL, Carey MS, Mills GB, Hotamisligil GS, Yamada SD, Peter ME, Gwin K, Lengyel E (2011) Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth. Nat Med 17:1498–1503

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  17. Iwami K, Momota H, Natsume A, Kinjo S, Nagatani T, Wakabayashi T (2012) A novel method of intracranial injection via the postglenoid foramen for brain tumor mouse models. J Neurosurg 116:630–635

    Article  CAS  PubMed  Google Scholar 

  18. Rodbell M (1964) Metabolism of isolated fat cells. I. effects of hormones on glucose metabolism and lipolysis. J Biol Chem 239:375–380

    CAS  PubMed  Google Scholar 

  19. Okamura A, Yazawa S, Nishimura T, Tanaka S, Takai I, Kudo S, Asao T, Kuwano H, Matta KL, Akamatsu S, Kochibe N (2000) A new method for assaying adhesion of cancer cells to the greater omentum and its application for evaluating anti-adhesion activities of chemically synthesized oligosaccharides. Clin Exp Metastasis 18:37–43

    Article  CAS  PubMed  Google Scholar 

  20. Baillie LD, Hagen V, Gardner KM, Mulligan SJ (2011) Functional imaging within individual pain fibres ex vivo with optical microscopy. J Neurosci Methods 198:274–279

    Article  PubMed  Google Scholar 

  21. Cavallotti C, Frati A, Cavallotti D, Tranquilli Leali FM (2004) Dopaminergic receptors in rat dura mater: pharmacological characteristics. Clin Exp Pharmacol Physiol 31:190–194

    Article  CAS  PubMed  Google Scholar 

  22. Khan SM, Funk HM, Thiolloy S, Lotan TL, Hickson J, Prins GS, Drew AF, Rinker-Schaeffer CW (2010) In vitro metastatic colonization of human ovarian cancer cells to the omentum. Clin Exp Metastasis 27:185–196

    Article  PubMed  Google Scholar 

  23. Nguyen DX, Bos PD, Massagué J (2009) Metastasis: from dissemination to organ-specific colonization. Nat Rev Cancer 9:274–284

    Article  CAS  PubMed  Google Scholar 

  24. Jain D, Sharma MC, Sarkar C, Suri V, Garg A, Singh M, Sharma BS, Mahapatra AK (2007) Clear cell meningioma, an uncommon variant of meningioma: a clinicopathologic study of nine cases. J Neurooncol 81:315–321

    Article  CAS  PubMed  Google Scholar 

  25. Yagi S, Kamei Y, Fujimoto Y, Torii S (2007) Use of the internal mammary vessels as recipient vessels for an omental flap in head and neck reconstruction. Ann Plast Surg 58:531–535

    Article  CAS  PubMed  Google Scholar 

  26. Kamei Y, Takada T, Yagi S, Fujimoto Y, Saito K, Takahashi M, Torii S (2005) Use of an omental flap for middle skull base reconstruction. Head Neck Cancer 31:498–502

    Google Scholar 

  27. Ichikawa M, Saito K, Ito E, Kawai K, Fujimoto Y, Kamei Y (2010) Iatrogenic drop metastasis of recurrent meningioma in a vascularized free omental flap—case report. Neurol Med Chir (Tokyo) 50:70–73

    Article  Google Scholar 

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Acknowledgments

The authors would like to thank the members of the Division of Experimental Animals and the Department of Pathology (Nagoya University) and Akira Kato for histology assistance and mouse maintenance. This work was supported by Grant-in-Aid for Young Scientists (B) (21790398) to Hiroyuki Momota, by Grant-in-Aid for Scientific Research (B) (21390408) to Atsushi Natsume, and by Grant-in-Aid for Scientific Research (C) (21591867) to Masazumi Fujii from the Japan Society for the Promotion of Science.

Conflict of interest

The authors report no conflict of interest concerning the materials or methods used in this study or the findings specified in this paper.

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Author notes

  1. Kenichiro Iwami

    Present address: Department of Neurosurgery, Japanese Red Cross Nagoya Daiichi Hospital, Nagoya, Japan

Authors and Affiliations

  1. Department of Neurosurgery, Nagoya University, Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan

    Kenichiro Iwami, Hiroyuki Momota, Masazumi Fujii, Atsushi Natsume & Toshihiko Wakabayashi

  2. Department of Plastic and Reconstructive Surgery, Nagoya University, Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan

    Shunjiro Yagi, Kazuhiro Toriyama & Yuzuru Kamei

Authors
  1. Kenichiro Iwami
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  2. Hiroyuki Momota
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Correspondence to Hiroyuki Momota.

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Iwami, K., Momota, H., Fujii, M. et al. Anaplastic meningioma with rapid growth after omental flap transposition: a case report and experimental study. Brain Tumor Pathol 32, 137–144 (2015). https://doi.org/10.1007/s10014-014-0190-4

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  • DOI: https://doi.org/10.1007/s10014-014-0190-4

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