Abstract
Eruption sequestrum (ES) is a single or even multiple, small whitish calcified masses found within the soft tissue of the opercula overlying the crown of erupting permanent molars of children. We herein report a well-documented case of ES, offering a review of published cases in the English literature. An otherwise healthy 6-year-old girl was seen for routine dental examination. A fragment of hard whitish tissue was observed in the gingiva overlying the erupting lower first permanent molar, which showed radiographic appearance of a faint round radiopacity above and separated from the occlusal surface of the related tooth. The patient was submitted to an excisional biopsy, and gross examination showed a hardened whitish fragment surrounded by gingival mucosa. Microscopic examination revealed odontogenic epithelium in association with chronic inflammatory infiltrate and small blood vessels in the connective tissue. Small concentric basophilic calcifications, round osteodentin, and pulp-like structures were also observed. The microscopic evaluation of additional cases of ES may improve the understanding of this uncommon inflamed odontogenic hamartoma.
Similar content being viewed by others
References
Starkey PE, Shafer WC (1963) Eruption sequestra in children. J Dent Child 30:84–86
Onishi T, Sakashita S, Ogawa T, Ooshima T (2003 Apr) Histopathological characteristics of eruption mesenchymal calcified hamartoma: two case reports. J Oral Pathol Med. 32(4):246–249
Watkins JJ (1975) An unusual eruption sequestrum a case report. Br Dent J 138:395–396
Gardner DE, Norwood JR (1978) Eruption sequestra: five case reports. J Dent Child 44:475–476
Kennedy DB (1980) Eruption sequestrae-three case reviews. J Pedodont 4:266–270
Priddy RW, Price C (1984 Sep) The so-called eruption sequestrum. Oral Surg Oral Med Oral Pathol. 58(3):321–326
Ho KH (1986) Eruption sequestrum. Ann Acad Med Singapore 15:454–455
Schuler JL, Camm JH, Houston G (1992) Bilateral eruption sequestra: report of case. ASDC J Dent Child 59:70–72
Maki K, Ansai T, Nishida I, Zhang M, Kojima Y, Takehara T, Kimura M (2005) Eruption sequestrum: x-ray microanalysis and microscopic findings. J Clin Pediatr Dent 29:245–247
Okawa R, Kimura KR, Fujita K, Nomura R, Nakano K, Fukuda Y, Ooshima T (2008) Eruption sequestrum identified in mandibular molar region: case report and review of literature. Ped Dent J. 18(2):200–203
de Queiroz AM, Rocha CT, da Silva LA, Brentegani LG, da Silva RA, de Rossi A, Nelson-Filho P (2012) Eruption sequestrum case report and histopathological findings. Braz Dent J. 23(6):764–767
Ooë T (1979 Jan 30) Development of human first and second permanent molar, with special reference to the distal portion of the dental lamina. Anat Embryol (Berl). 155(2):221–240
Ide F, Obara K, Yamada H, Mishima K, Saito I, Horie N, Shimoyama T, Kusama K (2007) Hamartomatous proliferations of odontogenic epithelium within the jaws: a potential histogenetic source of intraosseous epithelial odontogenic tumors. J Oral Pathol Med. 36:229–235
Azevedo RS, Mosqueda-Taylor A, Carlos R, Cabral MG, Romañach MJ, de Almeida OP, Pires FR (2013 Dec) Calcifying epithelial odontogenic tumor (CEOT): a clinicopathologic and immunohistochemical study and comparison with dental follicles containing CEOT-like areas. Oral Surg Oral Med Oral Pathol Oral Radiol. 116(6):759–768
Vargas PA, Carlos-Bregni R, Mosqueda-Taylor A, Cuairan-Ruidíaz V, Lopes MA, de Almeida OP (2006 Mar) Adenomatoid dentinoma or adenomatoid odontogenic hamartoma: what is the better term to denominate this uncommon odontogenic lesion? Oral Dis. 12(2):200–203
Carlos-Bregni R, Vargas PA, Santos Silva AR, Chaves-Netto HD, de Moraes M, Lopes MA (2009 Aug) Adenomatoid odontogenic hamartoma: concerns about correct nomenclature and 2 additional case reports. J Oral Maxillofac Surg. 67(8):1779–1780 author reply 1780
Serra-Serra G, Berini-Aytés L, Gay-Escoda C (2009 Jun 1) Erupted odontomas: a report of three cases and review of the literature. Med Oral Patol Oral Cir Bucal. 14(6):E299–E303
Author information
Authors and Affiliations
Contributions
ALOCR and TCAB contributed to the clinical and microscopic analyses of the case studied and review of the literature. KTB, ACA, MA, BABA, PAV, and MJR contributed to the study design, final data analyses, and manuscript writing and editing. All authors gave final approval and agreed to be accountable for all aspects of the work.
Corresponding author
Ethics declarations
Conflict of interest
The authors declare that they have no conflicts of interest.
Ethical approval
This article does not contain any studies with animals performed by any of the authors. All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Informed consent
Informed consent was obtained from all individual participants included in the study.
Additional information
Publisher’s note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Roza, A.L.O.C., de Abreu Brandi, T.C., Bezerra, K.T. et al. Eruption sequestrum: an inflamed odontogenic hamartoma. Oral Maxillofac Surg 24, 363–368 (2020). https://doi.org/10.1007/s10006-020-00865-4
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10006-020-00865-4