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Fludroxycortide cream as an alternative therapy for actinic cheilitis

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Abstract

Objectives

The objective of the study is to assess, by clinical follow-up, the efficacy of the dermatological cream Fludroxycortide 0.125 mg/g (Drenison®) in the treatment of actinic cheilitis (AC).

Material and methods

Twenty-three patients diagnosed with AC participated in the study. Fifteen were submitted to corticotherapy with Fludroxycortide, applied three times a day for up to 6 weeks, associated with lip sunscreen (LS) before sun exposure. In the control group of eight patients, only the use of LS was established. At each weekly return, a photographic record was made of the lesion. After treatment, images were evaluated and scores were assigned to verify clinical evolution. Also, patients treated with Fludroxycortide responded to a questionnaire, to assess drug tolerability and treatment satisfaction.

Results

In the group treated with Fludroxycortide (n = 15), five patients showed total improvement, seven presented partial improvement, and three showed no clinical change. Concerning the patients treated with LS (n = 8), one presented total remission of the clinical lesion characteristics, four exhibited partial improvement, and three exhibited no clinical lip alteration. No case presented symptom worsening. Of the 15 patients undergoing corticotherapy, 12 were satisfied and reported that the product was not irritating and contributed to lesion improvement.

Conclusions

Conventional treatment with LS was effective in the remission of some AC lesions, but treatment responses were improved when associated with Fludroxycortide, especially in the more severe cases.

Clinical relevance

As it is a non-invasive therapy leading, in most cases, to adequate clinical results, safety, and tolerability, Fludroxycortide can be considered an effective alternative treatment for AC.

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Funding

This study was funded by the authors and supported by the Department of Dentistry, Federal University of Rio Grande do Norte.

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Authors and Affiliations

  1. Department of Dentistry, Federal University of Rio Grande do Norte, Avenue Senador Salgado Filho, 1787, Lagoa Nova, Natal, RN, USA

    Hanna Isa de Oliveira Bezerra

  2. Postgraduate Program in Oral Pathology, Federal University of Rio Grande do Norte, Natal, RN, Brazil

    Amanda Katarinny Goes Gonzaga, Éricka Janine Dantas da Silveira, Patrícia Teixeira de Oliveira & Ana Miryam Costa de Medeiros

Authors
  1. Hanna Isa de Oliveira Bezerra
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  2. Amanda Katarinny Goes Gonzaga
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  3. Éricka Janine Dantas da Silveira
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  4. Patrícia Teixeira de Oliveira
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  5. Ana Miryam Costa de Medeiros
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Corresponding author

Correspondence to Hanna Isa de Oliveira Bezerra.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The study was approved by the Ethics Committee of the Federal University of Rio Grande do Norte (Protocol 1.846.133).

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Informed consent was obtained from all individual participants included in the study.

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de Oliveira Bezerra, H.I., Gonzaga, A.K.G., da Silveira, É.J.D. et al. Fludroxycortide cream as an alternative therapy for actinic cheilitis. Clin Oral Invest 23, 3925–3931 (2019). https://doi.org/10.1007/s00784-019-02823-1

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  • DOI: https://doi.org/10.1007/s00784-019-02823-1

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