Abstract.
We evaluated whether hysterectomy with ovarian conservation (HYX) has an effect on bone metabolism and density in 176 healthy Caucasian postmenopausal women aged 48–59 years. Bone properties of the hip, spine, radius, tibia, and calcaneus were measured using different bone assessment modalities. In addition, bone turnover was assessed using serum bone-specific alkaline phosphatase (BAP), osteocalcin (OC), and tartrate-resistant acid phosphatase (TRAP) 5b as biomarkers. Our results showed that women having HYX had a significantly lower level of OC (P = 0.017) and a marginally lower level of TRAP 5b (P = 0.051) and higher bone mineral density (BMD) of the femoral neck (P = 0.037) and lumbar spine (P = 0.001) than women with no history of HYX. In addition, the cortical BMD and bone strength index (Ipolar) of the tibia also showed higher values at different sections in women having HYX than women with no history of HYX (P = 0.055 to P < 0.005). These results suggest that the uterus may have a role in regulating bone metabolism that has not been detected previously.
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Received: March 19, 2002 / July 31, 2002
Acknowledgments. The authors thank Ms. Arja Nenonen and Mr. Erikki Hekala for their technical assistance for the study, and Drs. Harri Suominen, Kalervo Väänänen, Ilkka Vuori, and the staff at the UKK Institute for Health Promotion Research, Tampere, Finland, for their valuable work in this study. The study was supported by the UKK Institute for Health Promotion Research, Tampere; the Department of Health Sciences at University of Jyväskylä; Department of Anatomy at University of Turku, Finland; Merck and Co., USA; Metra Biosystems Inc., Mountain View, CA, USA; and Mission Pharmacal, San Antonio, TX, USA.
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Cheng, S., Sievänen, H., Heinonen, A. et al. Does hysterectomy with ovarian conservation affect bone metabolism and density?. J Bone Miner Metab 21, 12–16 (2003). https://doi.org/10.1007/s007740300002
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DOI: https://doi.org/10.1007/s007740300002