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Comparison of different parameters between daily and twice-weekly teriparatide in postmenopausal women with severe osteoporosis

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Abstract

Introduction

Once-daily teriparatide (D-TPTD) and twice-weekly TPTD (W-TPTD), which are self-administered injections, are generally used in the treatment of severe osteoporosis. This study aimed to reveal the differences in the persistence, safety, and effectiveness of D-TPTD and W-TPTD.

Materials and methods

A total of 102 patients received D-TPTD (n = 51) and W-TPTD (n = 51). The bone mineral densities (BMD) of the lumbar spine, total hip, and femoral neck were measured using dual energy X-ray absorptiometry. The persistence and effectiveness of the two treatments were compared at 12 months.

Results

The persistence in the D-TPTD and W-TPTD groups was 80.4% and 66.7% at 12 months, respectively (p = 0.178). The % changes (Δ) in BMD values from baseline for the lumbar spine in the D-TPTD were significantly higher than those in the W-TPTD (11.2% vs. 6.3%; p < 0.001) at 12 months. The ΔBMD values for the total hip (3.7% vs. 1.3%; p = 0.065) and femoral neck (2.2% vs. 1.6%; p = 0.489) did not differ significantly between the two groups at 12 months. The incidence of new morphological vertebral fractures in the D-TPTD and W-TPTD groups was 7.3% and 8.6%, respectively, at 12 months (p = 1.000).

Conclusions

Lumbar spine BMD (LS-BMD) was significantly increased. Moreover, ΔLS-BMD in the D-TPTD group was higher than that in the W-TPTD group. This study showed that the persistence, ΔTH-BMD, ΔFN-BMD and incidence of vertebral fractures did not differ between the two groups.

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Data availability statement

The data is not available due to ethical restrictions.

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Acknowledgements

The authors thank the patients who participated in this study. The authors also thank the medical staff and the clinical research center.

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Authors and Affiliations

  1. Department of Orthopedic Surgery, Kamagaya General Hospital, Kamagaya, Chiba, Japan

    Takeshi Mochizuki

  2. Department of Orthopedic Surgery, Tokyo Women’s Medical University, Tokyo, Japan

    Koichiro Yano, Katsunori Ikari & Ken Okazaki

Authors
  1. Takeshi Mochizuki
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  2. Koichiro Yano
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  3. Katsunori Ikari
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  4. Ken Okazaki
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Correspondence to Takeshi Mochizuki.

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Conflict of interest

T. Mochizuki received honoraria for lectures from AbbVie, Astellas, Bristol-Myers, Chugai, Daiichi Sankyo, Eisai, Eli Lilly, Janssen, Mochida, and Pfizer. Yano received honoraria for lectures from AbbVie, Astellas, Ayumi, Bristol-Meyers, Eisai, Hisamitsu, Mochida, and Takeda. K. Ikari received honoraria for lectures from AbbVie, Astellas, Bristol-Myers, Chugai, Eisai, Eli Lilly, Janssen, Takeda, Tanabe-Mitsubishi, and UCB. The other authors declare that they have no conflicts of interest. The sponsors were not involved in the study design; collection, analysis, and interpretation of data; writing of the article; and/or decision to submit the results for publication.

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Mochizuki, T., Yano, K., Ikari, K. et al. Comparison of different parameters between daily and twice-weekly teriparatide in postmenopausal women with severe osteoporosis. J Bone Miner Metab 41, 220–226 (2023). https://doi.org/10.1007/s00774-022-01398-4

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  • DOI: https://doi.org/10.1007/s00774-022-01398-4

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