Correction to: Amino Acids (2016) 48:1087–109 https://doi.org/10.1007/s00726-015-2163-2
This errata is for paper “Rapid acidolysis of benzyl group as a suitable approach for syntheses of peptides naturally produced by oxidative stress and containing 3-nitrotyrosine” as published in Amino Acids, 2016, 48 (4):1087–1098.
Due to unit conversion error from min−1 to s−1, some of the published numbers have to be divided by 3600. The conversion error affected not only our results, but also the conversion of published results concerning the acidolytic cleavage of tBu group (Lundt et al. 1978). Thus, some absolute values are different but the order of reaction rate and activation energy are consistent with published ones. The bigger difference occurred only for comparison of Tyr(Bn) vs. Nit(Bn) cleavage rates, i.e. instead of 2,000,000 times faster, the reaction is only ca 670 times faster. Nevertheless, after 30 min reaction time at 25 °C, the benzyl group was cleaved from Fmoc-Nit(Bn)-OH with TFA more than 98% (as it is visible from experimental data in Fig. 3, in published article). On the other hand, the right panel in Fig. 3—Arrhenius plot—had to be corrected. Since, the conversion error affected all rate constants, the activation energy remained the same. Moreover, the main message from the article stays valid and benzyl group is suitable protection for nitrotyrosine during the peptide synthesis using Fmoc/tBu strategy.
I apologize for this mistake.
Corrections:
Last two sentences in abstract should be: … rate k = 4.25 × 10−3 s−1 at 20 °C. This rate is ca more than 670 times faster than that for cleavage of benzyl from Tyr(Bn).
The similar correction should be in the introduction section: This cleavage is ca 670 times faster than that from Tyr(Bn) (Erickson and Merrifield 1973).
In the results and discussion section: In the case of Nit(Bn), we have determined k as 4.25 × 10−3 s−1 at 20 °C. Thus, the cleavage of benzyl from Nit(Bn) proceeds more than 670 times faster than that from Tyr(Bn). … Interestingly, since cleavage of tert.-butyl from Z-Tyr(tBu)-OH proceeded with k 8.67 × 10−4 s−1 (Lundt et al. 1978), …
Values of rate constants were corrected in Table 2:
Right panel in Fig. 3 and label were corrected:
Values were corrected in Supplementary Figure 2:
Author information
Authors and Affiliations
Corresponding author
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Niederhafner, P., Šafařík, M., Brichtová, E. et al. Correction to: Rapid acidolysis of benzyl group as a suitable approach for syntheses of peptides naturally produced by oxidative stress and containing 3-nitrotyrosine. Amino Acids 51, 1689–1690 (2019). https://doi.org/10.1007/s00726-019-02780-9
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00726-019-02780-9