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The role of receptors in the cross-species spread of coronaviruses infecting humans and pigs

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Abstract

The pandemic caused by SARS-CoV-2, which has proven capable of infecting over 30 animal species, highlights the critical need for understanding the mechanisms of cross-species transmission and the emergence of novel coronavirus strains. The recent discovery of CCoV-HuPn-2018, a recombinant alphacoronavirus from canines and felines that can infect humans, along with evidence of SARS-CoV-2 infection in pig cells, underscores the potential for coronaviruses to overcome species barriers. This review investigates the origins and cross-species transmission of both human and porcine coronaviruses, with a specific emphasis on the instrumental role receptors play in this process.

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Funding

This work was supported by the Liaoning Provincial Natural Science Foundation of China (2019-ZD-0804), Scientific Research Projects and Incubation Projects from the College of Animal Husbandry and Veterinary Medicine of Jinzhou Medical University (2023py07), and College Students Innovation and Entrepreneurship Training Programs (20201016039, 202310160015).

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Authors and Affiliations

  1. Department of Basic Veterinary Medicine, College of Animal Husbandry and Veterinary Medicine, Jinzhou Medical University, Jinzhou, 121000, China

    Jie Zhuang, Zhiwei Yan, Tiezhong Zhou & Huinuan Wang

  2. Department of Pathogenic Biology, School of Basic Medical Sciences, Jinzhou Medical University, Jinzhou, 121000, China

    Yonggang Li

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Zhiwei Yan and Jie Zhuang wrote the main manuscript text, Tiezhong Zhou prepared Figures 1, 2, 3, Yonggang Li and Huinuan Wang modified and checked the manuscript. All authors read and approved the final manuscript.

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Correspondence to Yonggang Li or Huinuan Wang.

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Zhuang, J., Yan, Z., Zhou, T. et al. The role of receptors in the cross-species spread of coronaviruses infecting humans and pigs. Arch Virol 169, 35 (2024). https://doi.org/10.1007/s00705-023-05956-7

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