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Effects of neddylation on viral infection: an overview

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Abstract

Neddylation is a post-translational modification that plays an important role not only in cancer development but also in regulating viral infection and replication. Upregulation of neddylation occurs in viral infections, and inhibition of neddylation can suppress viral replication. Neddylation is thought to enhance viral protein stability and replication. Neddylation has been reported to enhance the stability of the regulatory hepatitis B virus (HBV) X protein, modulate viral replication, and enhance hepatocarcinogenesis. Inhibition of neddylation using the NEDD8-activating enzyme E1 inhibitor MLN4924 inhibits viral replication, including that of HBV. Understanding of the role of neddylation in viral infections is critical for developing new therapeutic targets and potential treatment strategies. In this review, we discuss recent progress in the understanding of the effects of neddylation during viral infection, particularly in HBV infection, and strategies for curing viral infection by targeting the neddylation pathway.

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Funding

This study was supported by a grant from the Japan Agency for Medical Research and Development.

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Authors and Affiliations

  1. Department of Microbiology and Public Health, Faculty of Animal Science and Veterinary Medicine, Patuakhali Science and Technology University, Barishal, 8210, Bangladesh

    Mohammad Enamul Hoque Kayesh

  2. Department of Microbiology and Cell Biology, Tokyo Metropolitan Institute of Medical Science, Tokyo, 156-8506, Japan

    Michinori Kohara

  3. Transboundary Animal Diseases Centre, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, 890-0065, Japan

    Kyoko Tsukiyama-Kohara

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Conceptualization, MEHK, MK, and KT-K; writing-original draft preparation, MEHK, KT-K; writing-review and editing, MEHK, MK, and KT-K. All authors have read and agreed to the published version of the manuscript.

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Correspondence to Mohammad Enamul Hoque Kayesh or Kyoko Tsukiyama-Kohara.

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Kayesh, M.E.H., Kohara, M. & Tsukiyama-Kohara, K. Effects of neddylation on viral infection: an overview. Arch Virol 169, 6 (2024). https://doi.org/10.1007/s00705-023-05930-3

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  • DOI: https://doi.org/10.1007/s00705-023-05930-3

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