Skip to main content

Advertisement

SpringerLink
Log in

Human metapneumovirus strains circulating in Latin America

  • Brief Report
  • Published:
Archives of Virology Aims and scope Submit manuscript

Abstract

The human metapneumovirus (HMPV) is responsible for acute respiratory tract infections in young children, elderly patients, and immunocompromised hosts. In this study, we genetically analyzed the circulating HMPV in Central and South America from July 2008 to June 2009 and characterized the strains present in this region. Samples were collected during an international collaborative influenza like illness surveillance study and then sequenced with specific primers for the HMPV G gene. Our results show that two distinct clusters of HMPV circulated in Central and South America, subtypes A2 and B2 being the predominant strains.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

References

  1. Agapov E, Sumino KC, Gaudreault-Keener M, Storch GA, Holtzman MJ (2006) Genetic variability of human metapneumovirus infection: evidence of a shift in viral genotype without a change in illness. J Infect Dis 193:396–403

    Article  PubMed  CAS  Google Scholar 

  2. Bastien N, Liu L, Ward D, Taylor T, Li Y (2004) Genetic variability of the G glycoprotein gene of human metapneumovirus. J Clin Microbiol 42:3532–3537

    Article  PubMed  CAS  Google Scholar 

  3. Biacchesi S, Skiadopoulos MH, Boivin G, Hanson CT, Murphy BR, Collins PL, Buchholz UJ (2003) Genetic diversity between human metapneumovirus subgroups. Virology 315:1–9

    Article  PubMed  CAS  Google Scholar 

  4. Biacchesi S, Pham QN, Skiadopoulos MH, Murphy BR, Collins PL, Buchholz UJ (2005) Infection of nonhuman primates with recombinant human metapneumovirus lacking the SH, G, or M2–2 protein categorizes each as a nonessential accessory protein and identifies vaccine candidates. J Virol 79:12608–12613

    Article  PubMed  CAS  Google Scholar 

  5. Boivin G, Abed Y, Pelletier G, Ruel L, Moisan D, Cote S, Peret TC, Erdman DD, Anderson LJ (2002) Virological features and clinical manifestations associated with human metapneumovirus: a new paramyxovirus responsible for acute respiratory-tract infections in all age groups. J Infect Dis 186:1330–1334

    Article  PubMed  Google Scholar 

  6. Boivin G, De Serres G, Cote S, Gilca R, Abed Y, Rochette L, Bergeron MG, Dery P (2003) Human metapneumovirus infections in hospitalized children. Emerg Infect Dis 9:634–640

    PubMed  Google Scholar 

  7. Boivin G, Mackay I, Sloots TP, Madhi S, Freymuth F, Wolf D, Shemer-Avni Y, Ludewick H, Gray GC, LeBlanc E (2004) Global genetic diversity of human metapneumovirus fusion gene. Emerg Infect Dis 10:1154–1157

    PubMed  CAS  Google Scholar 

  8. Caracciolo S, Minini C, Colombrita D, Rossi D, Miglietti N, Vettore E, Caruso A, Fiorentini S (2008) Human metapneumovirus infection in young children hospitalized with acute respiratory tract disease: virologic and clinical features. Pediatr Infect Dis J 27:406–412

    Article  PubMed  Google Scholar 

  9. Chano F, Rousseau C, Laferriere C, Couillard M, Charest H (2005) Epidemiological survey of human metapneumovirus infection in a large pediatric tertiary care center. J Clin Microbiol 43:5520–5525

    Article  PubMed  Google Scholar 

  10. Cote S, Abed Y, Boivin G (2003) Comparative evaluation of real-time PCR assays for detection of the human metapneumovirus. J Clin Microbiol 41:3631–3635

    Article  PubMed  CAS  Google Scholar 

  11. Dollner H, Risnes K, Radtke A, Nordbo SA (2004) Outbreak of human metapneumovirus infection in Norwegian children. Pediatr Infect Dis J 23:436–440

    Article  PubMed  Google Scholar 

  12. Escobar C, Luchsinger V, de Oliveira DB, Durigon E, Chnaiderman J, Avendano LF (2009) Genetic variability of human metapneumovirus isolated from Chilean children, 2003–2004. J Med Virol 81:340–344

    Article  PubMed  Google Scholar 

  13. Esper F, Martinello RA, Boucher D, Weibel C, Ferguson D, Landry ML, Kahn JS (2004) A 1-year experience with human metapneumovirus in children aged <5 years. J Infect Dis 189:1388–1396

    Article  PubMed  Google Scholar 

  14. Galiano M, Videla C, Puch SS, Martinez A, Echavarria M, Carballal G (2004) Evidence of human metapneumovirus in children in Argentina. J Med Virol 72:299–303

    Article  PubMed  Google Scholar 

  15. Gray GC, Capuano AW, Setterquist SF, Erdman DD, Nobbs ND, Abed Y, Doern GV, Starks SE, Boivin G (2006) Multi-year study of human metapneumovirus infection at a large US Midwestern Medical Referral Center. J Clin Virol 37:269–276

    Article  PubMed  Google Scholar 

  16. Gray GC, Capuano AW, Setterquist SF, Sanchez JL, Neville JS, Olson J, Lebeck MG, McCarthy T, Abed Y, Boivin G (2006) Human metapneumovirus, Peru. Emerg Infect Dis 12:347–350

    Article  PubMed  Google Scholar 

  17. Ishiguro N, Ebihara T, Endo R, Ma X, Kikuta H, Ishiko H, Kobayashi K (2004) High genetic diversity of the attachment (G) protein of human metapneumovirus. J Clin Microbiol 42:3406–3414

    Article  PubMed  CAS  Google Scholar 

  18. Laguna-Torres VA, Sanchez-Largaespada JF, Lorenzana I, Forshey B, Aguilar P, Jimenez M, Parrales E, Rodriguez F, Garcia J, Jimenez I, Rivera M, Perez J, Sovero M, Rios J, Gamero ME, Halsey ES, Kochel TJ (2010) Influenza and other respiratory viruses in three Central American countries. Influenza Other Respir Viruses 5:123–134

    Article  Google Scholar 

  19. Mackay IM, Bialasiewicz S, Waliuzzaman Z, Chidlow GR, Fegredo DC, Laingam S, Adamson P, Harnett GB, Rawlinson W, Nissen MD, Sloots TP (2004) Use of the P gene to genotype human metapneumovirus identifies 4 viral subtypes. J Infect Dis 190:1913–1918

    Article  PubMed  CAS  Google Scholar 

  20. Meissner HC (2005) Reducing the impact of viral respiratory infections in children. Pediatr Clin North Am 52:695–710, v

    Google Scholar 

  21. Oliveira DB, Durigon EL, Carvalho AC, Leal AL, Souza TS, Thomazelli LM, Moraes CT, Vieira SE, Gilio AE, Stewien KE (2009) Epidemiology and genetic variability of human metapneumovirus during a 4-year-long study in Southeastern Brazil. J Med Virol 81:915–921

    Article  PubMed  CAS  Google Scholar 

  22. Peiris JS, Tang WH, Chan KH, Khong PL, Guan Y, Lau YL, Chiu SS (2003) Children with respiratory disease associated with metapneumovirus in Hong Kong. Emerg Infect Dis 9:628–633

    PubMed  Google Scholar 

  23. Peret TC, Abed Y, Anderson LJ, Erdman DD, Boivin G (2004) Sequence polymorphism of the predicted human metapneumovirus G glycoprotein. J Gen Virol 85:679–686

    Article  PubMed  CAS  Google Scholar 

  24. Piyaratna R, Tollefson SJ, Williams JV (2011) Genomic analysis of four human metapneumovirus prototypes. Virus Res 160:200–205

    Article  PubMed  CAS  Google Scholar 

  25. Pizzorno A, Masner M, Medici C, Sarachaga MJ, Rubio I, Mirazo S, Frabasile S, Arbiza J (2010) Molecular detection and genetic variability of human metapneumovirus in Uruguay. J Med Virol 82:861–865

    Article  PubMed  CAS  Google Scholar 

  26. Regev L, Hindiyeh M, Shulman LM, Barak A, Levy V, Azar R, Shalev Y, Grossman Z, Mendelson E (2006) Characterization of human Metapneumovirus infections in Israel. J Clin Microbiol 44:1484–1489

    Article  PubMed  CAS  Google Scholar 

  27. Schildgen V, van den Hoogen B, Fouchier R, Tripp RA, Alvarez R, Manoha C, Williams J, Schildgen O (2011) Human Metapneumovirus: lessons learned over the first decade. Clin Microbiol Rev 24:734–754

    Article  PubMed  Google Scholar 

  28. Talavera GA, Mezquita NE (2007) Human metapneumovirus in children with influenza-like illness in Yucatan, Mexico. Am J Trop Med Hyg 76:182–183

    PubMed  Google Scholar 

  29. Tollefson SJ, Cox RG, Williams JV (2010) Studies of culture conditions and environmental stability of human metapneumovirus. Virus Res 151: 54–59

    Google Scholar 

  30. Ulloa-Gutierrez R, Vargas-Jimenez F, Mora-Chavarria A, Umana MA, Calvo-Espinoza M, Alfaro-Bourrouet W (2009) Human metapneumovirus in Costa Rica. Pediatr Infect Dis J 28:452–453

    PubMed  Google Scholar 

  31. van den Hoogen BG, de Jong JC, Groen J, Kuiken T, de Groot R, Fouchier RA, Osterhaus AD (2001) A newly discovered human pneumovirus isolated from young children with respiratory tract disease. Nat Med 7:719–724

    Article  PubMed  Google Scholar 

  32. van den Hoogen BG, van Doornum GJ, Fockens JC, Cornelissen JJ, Beyer WE, de Groot R, Osterhaus AD, Fouchier RA (2003) Prevalence and clinical symptoms of human metapneumovirus infection in hospitalized patients. J Infect Dis 188:1571–1577

    Article  PubMed  Google Scholar 

  33. van den Hoogen BG, Osterhaus DM, Fouchier RA (2004) Clinical impact and diagnosis of human metapneumovirus infection. Pediatr Infect Dis J 23:S25–S32

    Article  PubMed  Google Scholar 

  34. Weinberg GA, Erdman DD, Edwards KM, Hall CB, Walker FJ, Griffin MR, Schwartz B (2004) Superiority of reverse-transcription polymerase chain reaction to conventional viral culture in the diagnosis of acute respiratory tract infections in children. J Infect Dis 189:706–710

    Article  PubMed  CAS  Google Scholar 

  35. Williams JV, Edwards KM, Weinberg GA, Griffin MR, Hall CB, Zhu Y, Szilagyi PG, Wang CK, Yang CF, Silva D, Ye D, Spaete RR, Crowe JE Jr (2010) Population-based incidence of human metapneumovirus infection among hospitalized children. J Infect Dis 201: 1890–1898

    Google Scholar 

  36. Williams JV, Harris PA, Tollefson SJ, Halburnt-Rush LL, Pingsterhaus JM, Edwards KM, Wright PF, Crowe JE Jr (2004) Human metapneumovirus and lower respiratory tract disease in otherwise healthy infants and children. N Engl J Med 350:443–450

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgments

We are grateful to Mrs. Victoria Espejo and Mrs. Ada Romero for technical support. This study was funded by the US Department of Defense Global Emerging Infections Surveillance and Response System (DoD-GEIS), a division of the Armed Forces Health Surveillance Center, WORK UNIT NUMBER: 847705.82000.25GB.B0016.

Conflict of interest

None of the authors has a financial or personal conflict of interest related to this study. The corresponding author had full access to all data in the study and final responsibility for the decision to submit this publication.

Author information

Authors and Affiliations

  1. United States Naval Medical Research Unit 6, Lima, Peru

    Josefina Garcia, Merly Sovero, Tadeusz Kochel, V. Alberto Laguna-Torres, Maria Ester Gamero & Eric S. Halsey

  2. Dirección General de Epidemiología, Ministerio de Salud, Lima, Perú

    Jorge Gomez

  3. Hospital Infantil Manuel de Jesus Rivera, Managua, Nicaragua

    Felix Sanchez

  4. Grupo Inmunovirología, Universidad de Antioquia, Medellín, Colombia

    Ana E. Arango

  5. Hospital Pablo Tobón Uribe, Medellín, Colombia

    Sergio Jaramillo

Authors
  1. Josefina Garcia
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Merly Sovero
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Tadeusz Kochel
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. V. Alberto Laguna-Torres
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Maria Ester Gamero
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Jorge Gomez
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Felix Sanchez
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Ana E. Arango
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Sergio Jaramillo
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Eric S. Halsey
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Josefina Garcia.

Additional information

The views expressed in this article are those of the authors and do not necessarily reflect the official policy or position of the Department of the Navy, Department of Defense, nor the U.S. Government.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Garcia, J., Sovero, M., Kochel, T. et al. Human metapneumovirus strains circulating in Latin America. Arch Virol 157, 563–568 (2012). https://doi.org/10.1007/s00705-011-1204-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00705-011-1204-8

Keywords

Search

Navigation