Abstract
Variation in antidepressive medication response according to 5-HT2A genotype has been reported in several studies. Temperament has been proposed to be one of the vulnerability factors in mood and anxiety disorders. We studied temperament profiles of 98 patients with major depression and explored the interaction between Temperament and Character Inventory (TCI) temperament dimensions, 5-HT2A genotype (SNPs rs6311, rs6313 and rs7997012) and treatment response. No interactive effects for TCI temperament dimensions and 5-HT2A genotypes on antidepressive treatment response were found.
This is a preview of subscription content, log in via an institution to check access.
References
Bortolozzi A, Díaz-Mataix L, Scorza MC, Celada P, Artigas F (2005) The activation of 5-HT2A receptors in prefrontal cortex enhances dopaminergic activity. J Neurochem 95(6):1597–1607
Burnet PW, Eastwood SL, Lacey K, Harrison PJ (1995) The distribution of 5-HT1A and 5HT2A receptor mRNA in human brain. Brain Res 676(1):157–168
Choi MJ, Kang RH, Ham BJ, Jeong HY, Lee MS (2005) Serotonin receptor 2A gene polymorphism 1438(A/G) and short-term treatment response to citalopram. Neuropsychobiology 52:155–162
Cloninger CR, Svrakic DM, Przybeck TR (1993) A psychobiological model of temperament and character. Arch Gen Psychiatry 50:975–990
Fisher PM, Meltzer CC, Price JC, Coleman RL, Ziolko SK, Ziolko SK, Becker C, Moses-Kolko EL, Berga SL, Hariri AR (2009) Medial prefrontal cortex 5-HT(2A) density is correlated with amygdala reactivity, response habituation, and functional coupling. Cereb Cortex 19(11):2499–2507
Golimbet VE, Alfimova MV, Mitiushina NG (2004) Polymorphism of the serotonin 2A receptor gene (5HTR2A) and personality traits. Mol Biol (Mosk) 38(3):404–412
Illi A, Setälä-Soikkeli E, Viikki M, Poutanen O, Huhtala H, Mononen N, Lehtimäki T, Leinonen E, Kampman O (2009) 5-HTR1A, 5-HTR2A, 5-HTR6, TPH1 and TPH2 polymorphisms and major depression. Neuroreport 468(1):80–84
Jokela M, Lehtimäki T, Keltikangas-Järvinen L (2007) The serotonin receptor 2A gene moderates the influence of parental socioeconomic status on adulthood harm avoidance. Behav Genet 37(4):567–574
Kato M, Fukuda T, Wakeno M, Fukuda K, Okugawa G, Ikenaga Y et al (2006) Effects of the serotonin type 2A, 3A and 3B receptor and the serotonin transporter genes on paroxetine and fluvoxamine efficacy and adverse drug reactions in depressed Japanese patients. Neuropsychobiology 53:186–195
Lucae S, Ising M, Horstmann S, Baune BT, Arolt V, Müller-Myhsok B, Holsboer F, Domschke K (2010) HTR2A gene variation is involved in antidepressant treatment response. Eur Neuropsychopharmacol 20(1):65–68
McMahon FJ, Buervenich S, Charney D, Lipsky R, Rush AJ, Wilson AF et al (2006) Variation in the gene encoding the serotonin 2A receptor is associated with outcome of antidepressant treatment. Am J Hum Genet 78:804–814
Montgomery SA, Asberg M (1979) A new depression scale designed to be sensitive to change. Brit J Psychiatry 134:382–389
Paddock S, Laje G, Charney D, Rush AJ, Wilson AF, Sorant AJ, Lipsky R, Wisniewski SR, Manji H, McMahon FJ (2007) Association of GRIK4 with outcome of antidepressant treatment in the STAR*D cohort. Am J Psychiatry 164:1181–1188
Peters EJ, Slager SL, Jenkins GD, Reinalda MS, Garriocka HA, Shyna SI, Krafta JB, McGrathc PJ, Hamilton SP (2009) Resequencing of serotonin-related genes and association of tagging SNPs to citalopram response. Pharmacogenet Genom 19:1–10
Serretti A, Calati R, Giegling I, Hartmann AM, Möller HJ, Colombo C, Rujescu D (2007) 5-HT2A SNPs and the temperament and character inventory. Prog Neuropsychopharmacol Biol Psychiatry 31(6):1275–1281
Van Heeringen C, Audenaert K, Van Laere K, Dumont F, Slegers G, Mertens J, Dierckx RA (2003) Prefrontal 5-HT2a receptor binding index, hopelessness and personality characteristics in attempted suicide. J Affect Disord 74(2):149–158
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Andre, K., Kampman, O., Setälä-Soikkeli, E. et al. Temperament profiles, 5-HT2A genotype, and response to treatment with SSRIs in major depression. J Neural Transm 117, 1431–1434 (2010). https://doi.org/10.1007/s00702-010-0512-6
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00702-010-0512-6